Journal
MARINE DRUGS
Volume 14, Issue 11, Pages -Publisher
MDPI AG
DOI: 10.3390/md14110201
Keywords
briarane diterpenoids; biological activity; structure elucidation; gorgonian; Dichotella gemmacea
Categories
Funding
- NSFC [81573342, U1405227, 41576157, 81502978]
- Program of Shanghai Subject Chief Scientist [15XD1504600]
- Hundred Talents Program of SMCH [XBR2013111]
- key project of STCSM [14431902900]
- Youth Program of SMMU [2014QN08]
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Seven new briarane diterpenoids, gemmacolides AZ-BF (1-7), were isolated together with eight known analogues (8-15) from the South China gorgonian Dichotella gemmacea. Their structures were elucidated based on detailed spectroscopic analysis and a comparison with reported data. In an in vitro bioassay, these compounds exhibited different levels of growth inhibition activity against A549 and MG63 cells, giving continuous evidences about the biological contribution of functional groups at C-2, C-12, C-13, and C-16. These compounds were also evaluated for their antibacterial and antifungal activities. Compound 8 exhibited a potential antibacterial activity against both Gram-positive bacterium Bacillus megaterium and Gram-negative bacterium Escherichia coli.
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