Dental loss, stress fractures, and musculoskeletal pain in a 48-year-old woman

Article Dentistry, Oral Surgery & Medicine

Dental manifestation and management of hypophosphatasia

Rena Okawa et al.

Summary: Hypophosphatasia is an inherited metabolic disorder characterized by defective mineralization of bones and teeth. Enzyme replacement therapy has greatly improved the prognosis of severe patients. Dental symptoms, such as early exfoliation of primary teeth, can be improved with enzyme replacement therapy. Mild patients have different genetic and dental manifestations compared to severe forms. Early diagnosis is important for intervention in both medical and dental fields.

JAPANESE DENTAL SCIENCE REVIEW (2022)

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Article Environmental Sciences

Full Arch Implant-Prosthetic Rehabilitation in Patients with Type I Diabetes Mellitus: Retrospective Clinical Study with 10 Year Follow-Up

Bianca D'Orto et al.

Summary: This retrospective clinical study compared the outcomes of full arch implant-prosthetic rehabilitation in healthy patients and patients with type I diabetes. The results showed no significant differences in implant survival rates, marginal bone loss, or clinical and prosthetic complications between the two groups. However, post-surgical bleeding and wound infection were more common in patients with compensated diabetes.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Review Biochemistry & Molecular Biology

Hypophosphatasia: A Unique Disorder of Bone Mineralization

Juan Miguel Villa-Suarez et al.

Summary: HPP is a rare genetic disease characterized by decreased TNSALP activity, caused by high allelic heterogeneity of the ALPL gene. The complications are mainly due to the accumulation of inorganic pyrophosphate (PPi) and pyridoxal-5 '-phosphate (PLP).

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy