Journal
MALARIA JOURNAL
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12936-016-1131-y
Keywords
sHLA-G; Evolution; Groups; Infancy; Malaria; Benin
Categories
Funding
- Agence Nationale de la Recherche (SEST (Sante Environnement Sante Travail) [2006/040/001]
- Ministere des Affaires Etrangeres (REFS project) [2006-22]
- Institut de Recherche pour le Developpement
- Fondation pour la Recherche Medicale [FDM20130727043]
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Background: HLA-G, a non-classical HLA class I antigen, is of crucial interest during pregnancy by inhibiting maternal immune response. Its role during infections is discussed, and it has been described that high levels of soluble HLA-G during childhood increase the risk of malaria. To explore more precisely interactions between soluble HLA-G and malaria, latent class analysis was used to test whether distinct sub-populations of children, each with distinctive soluble HLA-G evolutions may suggest the existence of groups presenting variable malaria susceptibility. Method: A study was conducted in Benin from 2010 to 2013 and 165 children were followed from birth to 12 months. Evolution of soluble HLA-G was studied by the latent class method. Results: Three groups of children were identified: one with consistently low levels of soluble HLA-G during follow-up, a second with very high levels and a last intermediate group. In all groups, low birth weight, high number of malaria infections and high exposure to malaria transmission were associated with high level of soluble HLA-G. Placental malaria was not. Presence of soluble HLA-G in cord blood increased the probability of belonging to the highest trajectory. Conclusion: These results, together with previous ones, confirm the important role of HLA-G in the individual susceptibility to malaria. Assaying soluble HLA-G at birth could be a good indicator of newborns more fragile and at risk of infections during childhood.
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