Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 77, Issue 3, Pages 1318-1328Publisher
WILEY
DOI: 10.1002/mrm.26210
Keywords
magnetization transfer; myelin membrane; white matter; lipid dynamics
Funding
- United States National Center for Advancing Translational Sciences, National Institutes of Health [UL1TR000433]
- Department of Radiology, University of Michigan
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Purpose: To elucidate the dynamic, structural, and molecular properties that create inhomogeneous magnetization transfer (ihMT) contrast. Methods: Amphiphilic lipids, lamellar phospholipids with cholesterol, and bovine spinal cord (BSC) specimens were examined along with nonlipid systems. Magnetization transfer (MT), enhanced MT (eMT, obtained with double-sided radiofrequency saturation), ihMT (MT - eMT), and dipolar relaxation, T1D, were measured at 2.0 and 11.7 T. Results: The amplitude of ihMT ratio (ihMTR) is positively correlated with T1D values. Both ihMTR and T1D increase with increasing temperature in BSC white matter and in phospholipids and decrease with temperature in other lipids. Changes in ihMTR with temperature arise primarily from alterations in MT rather than eMT. Spectral width of MT, eMT, and ihMT increases with increasing carbon chain length. Conclusions: Concerted motions of phospholipids in white matter decrease proton spin diffusion leading to increased proton T1D times and increased ihMT amplitudes, consistent with decoupling of Zeeman and dipolar spin reservoirs. Molecular specificity and dynamic sensitivity of ihMT contrast make it a suitable candidate for probing myelin membrane disorders. (C) 2016 International Society for Magnetic Resonance in Medicine
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