Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 77, Issue 1, Pages 310-317Publisher
WILEY
DOI: 10.1002/mrm.26085
Keywords
MRI; intravoxel incoherent motion; IVIM; diffusion; perfusion; NNLS; liver; blood flow
Funding
- LABEX PRIMES of Universite de Lyon, within the program Investissements d'Avenir [ANR-11-LABX-0063, ANR-11-IDEX-0007]
Ask authors/readers for more resources
PurposeTissue perfusion measurements using intravoxel incoherent motion (IVIM) diffusion-MRI are of interest for investigations of liver pathologies. A confounding factor in the perfusion quantification is the partial volume between liver tissue and large blood vessels. The aim of this study was to assess and correct for this partial volume effect in the estimation of the perfusion fraction. MethodsMRI experiments were performed at 3 Tesla with a diffusion-MRI sequence at 12 b-values. Diffusion signal decays in liver were analyzed using the non-negative least square (NNLS) method and the biexponential fitting approach. ResultsIn some voxels, the NNLS analysis yielded a very fast-decaying component that was assigned to partial volume with the blood flowing in large vessels. Partial volume correction was performed by biexponential curve fitting, where the first data point (b=0 s/mm(2)) was eliminated in voxels with a very fast-decaying component. Biexponential fitting with partial volume correction yielded parametric maps with perfusion fraction values smaller than biexponential fitting without partial volume correction. ConclusionThe results of the current study indicate that the NNLS analysis in combination with biexponential curve fitting allows to correct for partial volume effects originating from blood flow in IVIM perfusion fraction measurements. Magn Reson Med 77:310-317, 2017. (c) 2016 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available