Journal
MAGNETIC RESONANCE IMAGING
Volume 34, Issue 10, Pages 1373-1376Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2016.08.016
Keywords
Gadolinium; Toxicity; Iron; Ferroportin; Brain; Macrophage
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases of the NIH [1R01DK103043-01 A1]
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Gadolinium-based magnetic resonance (MR) contrast agents (GBCM) causes a devastating systemic fibrosing illness, nephrogenic systemic fibrosis (NSF), in patients with reduced kidney function. GBCM targets iron-recycling CD163- and ferroportin-expressing macrophages to release labile iron that mediates gadolinium toxicity and NSF. GBCA might similarly target iron-rich, ferroportin-expressing structures such as globus pallidus and cerebellar dentate nucleus in the brain to result in metal accumulation and potential toxicity. (C) 2016 Elsevier Inc. All rights reserved.
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