Journal
MACROMOLECULES
Volume 49, Issue 14, Pages 5017-5025Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.6b00958
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Funding
- Singapore NRF Competitive Research Program [R279-000-483-281]
- NRF Investigatorship [R279-000-444-281]
- National University of Singapore [R279-000-482-133]
- Institute of Materials Research and Engineering of Singapore [IMRE/14-8P1110]
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Far-red (FR)/near-infrared (NIR) photosensitizer is highly desirable in image-guided photodynamic cancer therapy. Herein, a new conjugated polymer of poly(1,2-bis(4-((6-bromohexyl)oxy)phenyl)-1,2-diphenylethene-co-a/t-9,10-anthraquinone) (PTPEAQ) consisting of tetraphenylethylene (TPE), an iconic aggregation-induced emission (AIE) active group as the electron donor, and anthraquinone (AQ) as the acceptor, is prepared for the first time through one-pot Suzuki polymerization. Encapsulation of PTPEAQ with a block copolymer followed by surface functionalization with anti-Her2 affibody yields PTPEAQ-NP-HER2. It shows bright AIE-active FR/NIR emission and efficient singlet oxygen generation under visible light irradiation, which has been successfully used for photodynamic cancer cell ablation using SKBR-3 cells, a type of breast cancer cell with HER2 overexpression on cell membrane, as an example.
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