4.5 Article

Design, synthesis, anticancer evaluation and molecular docking studies of 1,2,3-triazole incorporated 1,3,4-oxadiazole-Triazine derivatives

Related references

Note: Only part of the references are listed.
Review Chemistry, Physical

A review on synthesis, mechanism of action, and structure-activity relationships of 1,2,3-triazole-based alpha-glucosidase inhibitors as promising anti-diabetic agents

Zari Fallah et al.

Summary: Alpha-glucosidase inhibitors play a crucial role in the treatment of diabetes, and 1,2,3-triazole-based derivatives have attracted much interest in this field. The click reaction is a potent tool for synthesizing hybrid molecules containing 1,2,3-triazole ring and other effective pharmacophors for alpha-glucosidase inhibition.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Article Pharmacology & Pharmacy

Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl s-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (MDA-MB-231) via EGFR/PI3K/AKT/mTOR Signaling Cascades

Ihab Shawish et al.

Summary: In this study, a one-pot synthetic procedure was used to synthesize novel pyrazole-s-triazine derivatives with high efficiency and yield. These derivatives exhibited cytotoxicity against various cancer cell lines, with certain compounds showing potent anti-tumor activity.

PHARMACEUTICS (2022)

Article Chemistry, Multidisciplinary

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)-s-triazine Derivatives Targeting EGFR/ PI3K/AKT/mTOR Cascades

Ihab Shawish et al.

Summary: In this study, a series of novel 1,3,5-triazine derivatives were synthesized and their inhibitory activity against cancer cells was evaluated through in vitro assays. Among them, compound 4f showed significant antitumor activity and induced apoptosis by targeting EGFR and its downstream pathway.

ACS OMEGA (2022)

Article Chemistry, Multidisciplinary

Benzoxazole derivatives: design, synthesis and biological evaluation

Saloni Kakkar et al.

CHEMISTRY CENTRAL JOURNAL (2018)

Article Chemistry, Medicinal

Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents

Ehtesham Jameel et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Chemistry, Multidisciplinary

Synthesis and biological evaluation of dihydrotriazine derivatives as potential antibacterial agents

Tian-Yi Zhang et al.

CHINESE CHEMICAL LETTERS (2017)

Article Biochemistry & Molecular Biology

Triazine-benzimidazole hybrids: Anticancer activity, DNA interaction and dihydrofolate reductase inhibitors

Prinka Singla et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

Antimicrobial evaluation, QSAR and docking studies of amide-linked 1,4-disubstituted 1,2,3-bistriazoles

Kashmiri Lal et al.

MEDICINAL CHEMISTRY RESEARCH (2015)

Article Chemistry, Medicinal

1H-1,2,3-triazole tethered mono- and bis-ferrocenylchalcone-β-lactam conjugates: Synthesis and antimalarial evaluation

Kewal Kumar et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

Review Chemistry, Multidisciplinary

Click Chemistry for Drug Development and Diverse Chemical-Biology Applications

Prakasam Thirumurugan et al.

CHEMICAL REVIEWS (2013)

Article Biochemistry & Molecular Biology

Synthesis of quinoline coupled [1,2,3]-triazoles as a promising class of anti-tuberculosis agents

K. Karthik Kumar et al.

CARBOHYDRATE RESEARCH (2011)

Review Chemistry, Multidisciplinary

Click Chemistry: 1,2,3-Triazoles as Pharmacophores

Sandip G. Agalave et al.

CHEMISTRY-AN ASIAN JOURNAL (2011)

Article Biochemistry & Molecular Biology

Synthesis of 1-(D-glucopyranosyl)-1,2,3-triazoles and their evaluation as glycogen phosphorylase inhibitors

Eva Bokor et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2010)

Article Chemistry, Medicinal

Synthesis and antimicrobial activity of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines

Mona Saleh et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Chemistry, Medicinal

Synthesis of 10-substituted triazolyl artemisinins possessing anticancer activity via Huisgen 1,3-dipolar cylcoaddition

Sungsik Cho et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Article Chemistry, Medicinal

Synthesis, HIV-RT inhibitory activity and SAR of 1-benzyl-1H-1,2,3-triazole derivatives of carbohydrates

Fernando de C. da Silva et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Chemistry, Medicinal

Synthesis and cytotoxic activity of trisubstituted-1,3,5-triazines

Kapil Arya et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Article Biochemistry & Molecular Biology

Synthesis and antitumor evaluation of a novel series of triaminotriazine derivatives

Mingfang Zheng et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1,2,3-triazole derivatives

Marilia S. Costa et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2006)

Review Pharmacology & Pharmacy

The growing impact of click chemistry on drug discovery

HC Kolb et al.

DRUG DISCOVERY TODAY (2003)