Recent advances in CD8+T cell-based immune therapies for HIV cure

Achieving a cure for HIV infection is a global priority. There is substantial evidence supporting a central role for CD8+ T cells in the natural control of HIV, suggesting the rationale that these cells may be exploited to achieve remission or cure of this infection. In this work, we review the major challenges for achieving an HIV cure, the models of HIV remission, and the mechanisms of HIV control mediated by CD8+ T cells. In addition, we discuss strategies based on this cell population that could be used in the search for an HIV cure. Finally, we analyze the current challenges and perspectives to translate this basic knowledge toward scalable HIV cure strategies.

Automated summary

Achieving a cure for HIV infection is a global priority, and CD8+ T cells play a central role in the natural control of HIV, suggesting their potential for use in achieving remission or cure. This work reviews the challenges, models, and mechanisms related to HIV control mediated by CD8+ T cells, and discusses strategies based on this cell population in the search for an HIV cure. Finally, the current challenges and perspectives in translating this knowledge into scalable HIV cure strategies are analyzed.