The role of the circadian rhythms in critical illness with a focus on acute pancreatitis

Circadian rhythms are responsible for governing various physiological processes, including hormone secretion, immune responses, metabolism, and the sleep/wake cycle. In critical illnesses such as acute pancreatitis (AP), circadian rhythms can become dysregulated due to disease. Evidence suggests that time of onset of disease, coupled with peripheral inflammation brought about by AP will impact on the circadian rhythms generated in the central pacemaker and peripheral tissues. Cells of the innate and adaptive immune system are governed by circadian rhythms and the diurnal pattern of expression can be disrupted during disease. Peak circadian immune cell release and gene expression can coincide with AP onset, that may increase pancreatic injury, tissue damage and the potential for systemic inflammation and multiple organ failure to develop. Here, we provide an overview of the role of circadian rhythms in AP and the underpinning inflammatory mechanisms to contextualise ongoing research into the chronobiology and chronotherapeutics of AP.

Automated summary

Circadian rhythms play an important role in regulating various physiological processes, and dysregulation of these rhythms can occur in critical illnesses such as acute pancreatitis (AP). Evidence suggests that the timing of disease onset and peripheral inflammation can impact circadian rhythms in both the central pacemaker and peripheral tissues, leading to disruption in immune cell release and gene expression. This disruption may contribute to increased pancreatic injury, tissue damage, and the development of systemic inflammation and multiple organ failure.