Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 37, Issue 9, Pages 775-780Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201600080
Keywords
acid-cleavable; amphiphilic copolymers; minie-mulsions; nonionic surfactants; poloxamers
Categories
Funding
- Max Planck Graduate Center (MPGC)
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Poly ((ethylene oxide)-b-(propylene oxide)-b-(ethylene oxide)) triblock copolymers commonly known as poloxamers or Pluronics constitute an important class of nonionic, biocompatible surfactants. Here, a method is reported to incorporate two acid-labile acetal moieties in the backbone of poloxamers to generate acid-cleavable nonionic surfactants. Poly(propylene oxide) is functionalized by means of an acetate-protected vinyl ether to introduce acetal units. Three cleavable PEO-PPO-PEO triblock copolymers (M-n,M- total = 6600, 8000, 9150 g.mol(-1); M-n,M- PEO = 2200, 3600, 4750 g.mol(-1)) have been synthesized using anionic ring-opening polymerization. The amphiphilic copolymers exhibit narrow molecular weight distributions (D = 1.06-1.08). Surface tension measurements reveal surface-active behavior in aqueous solution comparable to established noncleavable poloxamers. Complete hydrolysis of the labile junctions after acidic treatment is verified by size exclusion chromatography. The block copolymers have been employed as surfactants in a miniemulsion poly merization to generate polystyrene (PS) nanoparticles with mean diameters of similar or equal to 200 nm and narrow size distribution, as determined by dynamic light scattering and scanning electron microscopy. Acid-triggered precipitation facilitates removal of surfactant fragments from the nanoparticles, which simplifies purification and enables nanoparticle precipitation on demand.
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