Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 37, Issue 9, Pages 739-744Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201500755
Keywords
carbon monoxide; drug delivery; macromolecules; nanoparticles; RAFT polymerization
Categories
Funding
- Australian Research Council [FT12010096]
- UNSW
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CORM-2, tricarbonyldichlororuthenium(II) dimer (Ru2Cl4(CO)(6)), is a common carbon monoxide releasing molecule (CORM) studied both in vitro and in vivo, but this compound possesses poor water solubility and a short half-life, which hinders its clinical development. Herein, for the first time the conjugation of CORM-2 is reported with a copolymer containing poly(4-vinylpyridine) to yield water-soluble CO-releasing polymeric nanoparticles. CORM-2 is rapidly conjugated to copolymers through pyridine groups as confirmed by inductively coupled plasma-optical emission spectroscopy and infrared spectroscopy. In comparison with free CORM-2, the copolymers functionalized with CORM-2 display better water solubility and the CO release from the polymer-based CORM is slow and sustained. This study paves the way for the potential use of a copolymer encapsulating CORM-2 as a therapeutic agent.
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