Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 37, Issue 21, Pages 1723-1728Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201600323
Keywords
injectable hydrogels; multi-block copolymers; Pluronics; self-healing
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Funding
- National Natural Science Foundation of China [51273189]
- National Science and Technology Major Project of the Ministry of Science and Technology of China [2011ZX05010-003]
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Injectable hydrogels have been commonly used as drug-delivery vehicles and tried in tissue engineering. Injectable self-healing hydrogels have great advantage over traditional injectable hydrogels because they can be injected as a liquid and then rapidly form bulk gels in situ at the target site under physiological conditions. This study develops an injectable thermosensitive self-healing hydrogel based on chain-extended F127 (PEO90-PPO65-PEO90) multi-block copolymer (m-F127). The rapid sol-gel transition ability under body temperature allows it to be used as injectable hydrogel and the self-healing property allows it to withstand repeated deformation and quickly recover its mechanical properties and structure through the dynamic covalent bonds. It is hoped that the novel strategy and the fascinating properties of the hydrogel as presented here will provide new opportunities with regard to the design and practical application of injectable self-healing hydrogels.
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