Journal
MACROMOLECULAR MATERIALS AND ENGINEERING
Volume 301, Issue 8, Pages 972-981Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mame.201600018
Keywords
barrier membranes; bone tissue engineering; electrospinning; guided bone regeneration; strontium-substituted bioactive glass
Funding
- UK Engineering and Physical Sciences Research Council (EPSRC)
- MeDe Innovation (the EPSRC Centre for Innovative Manufacturing in Medical Devices) [EP/K029592/1]
- Engineering and Physical Sciences Research Council [EP/K029592/1] Funding Source: researchfish
- EPSRC [EP/K029592/1] Funding Source: UKRI
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Barrier membranes used for the treatment of bone tissue defects caused by periodontitis lack the ability to promote new bone tissue regeneration. However, the addition of an osteogenic component to membranes may enhance their regenerative potential. Here the manufacturing of composite membranes made of poly(caprolactone) and strontium-substituted bioactive glass is described using the solution-electrospinning technique, with particles located both inside and on the surface of the fibers. All membranes are characterized using scanning electron microscopy and energy dispersive X-ray spectroscopy, and glass dissolution from within the fibers is investigated in water. In vitro material cytotoxicity is determined using a rat osteosarcoma cell line. Electrospun fibers exhibit porous surfaces and regions of increased diameter where the particles are accumulated. The glass dissolves after immersion in water, releasing dissolution products that are associated with increased pH. Further evidence suggests accelerated polymer degradation due to interactions between both components, which may provide the additional benefit of reducing the pH changes associated with glass dissolution. All compositions are biocompatible in vitro, with the exception of membranes with >50 mu g of glass on their surface. In conclusion, these membranes show great potential for bone healing applications, including guided bone regeneration and scaffolds for musculoskeletal tissue engineering.
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