Journal
MACROMOLECULAR CHEMISTRY AND PHYSICS
Volume 217, Issue 10, Pages 1197-1204Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.201500517
Keywords
kappa-carrageenan; supramolecular hydrogel; syneresis; tissue engineering
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Funding
- NSFC [51573092, 51273111, 51173105]
- National Basic Research Program of China (973 Program) [2012CB933803]
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Syneresis property limits the further application of Kappa-carrageenan (kappa-CG) in cell culture scaffold. To address this problem, kappa-CG hydrogel is tailored by blending with a C2-symmetric benzene-based supramolecular gelator ( B2). Scanning electron microscope ( SEM) and Fourier transform infrared ( FT-IR) spectroscopy confirm the semi-interpenetrating ( semi-IPN) structure of the blended hydrogels and their wettability or thermal stability is also found to be improved. Based on the reduced syneresis, the growth and proliferation of the cultured HCT 116 cells on the blended hydrogels is enhanced compared with pure kappa-CG hydrogels. This study paves an easy and feasible way to achieve stable and biocompatible kappa-CG/B2 blended hydrogels with high water retention and it helps broaden the promising applications of kappa-CG hydrogels in tissue engineering.
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