Journal
MACROMOLECULAR BIOSCIENCE
Volume 17, Issue 5, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201600340
Keywords
antitumor activity; fucoidan; polymer branching; structure-activity relationship; sulfation
Funding
- INTERREG /POCTEP, CarbPol_u_Algae [EXPL/MAR-BIO/0165/2013]
- Portuguese Foundation for Science and Technology, FCT [IF/00376/2014/CP1212/CT0015]
- ComplexiTE [ERC-2012-ADG 20120216-321266]
- European Research Council under the European Union
- FCT, Portugal
- OOPNA, through national founds [UID/OUI/00062/2013]
- FEDER
- [0687_NOVOMAR_1_P]
- [SFRH/BD/102471/2014]
- [SFRH/BPD/100627/2014]
- [IF/00376/2014]
- [IF/00373/2014]
- [IF/00032/2013]
- [POCI-01-0145-FEDER-007679]
- [FCT UID/CTM/50011/2013]
- Fundação para a Ciência e a Tecnologia [EXPL/MAR-BIO/0165/2013, IF/00376/2014/CP1212/CT0015] Funding Source: FCT
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There is an urgent need for antitumor bioactive agents with minimal or no side effects over normal adjacent cells. Fucoidan is a marine-origin polymer with known antitumor activity. However, there are still some concerns about its application due to the inconsistent experimental results, specifically its toxicity over normal cells and the mechanism behind its action. Herein, three fucoidan extracts (FEs) have been tested over normal and breast cancer cell lines. From cytotoxicity results, only one of the extracts shows selective antitumor behavior (at 0.2 mg mL(-1)), despite similarities in sulfation degree and carbohydrates composition. Although the three FEs present different molecular weights, depolymerization of selected samples discarded M-w as the key factor in the antitumor activity. Significant differences in sulfates position and branching are observed, presenting FE 2 the higher branching degree. Based on all these experimental data, it is believed that these last two properties are the ones that influence the cytotoxic effects of fucoidan extracts.
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