Journal
MACROMOLECULAR BIOSCIENCE
Volume 17, Issue 1, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201600228
Keywords
controlled release; drug microparticles; drug nanoparticles; layer-by-layer; polyelectrolytes
Funding
- Swiss National Science Foundation [SNF 310030-138342]
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Layer-by-layer coating is a simple and versatile technique based on the sequential deposition of molecular species on planar surfaces or colloidal templates. Its relevance in drug delivery primarily emerges from its versatility to control the release rate of the cargo encapsulated within the colloidal core. The focus of this review is the layer-by-layer encapsulation of colloidal particles purely composed of drug, including the core fabrication step, coating materials and techniques, multilayer shell permeability control, and reported in vitro and in vivo outcomes.
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