4.5 Article

Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating H2O2-induced liver injury in HepG2 cells

Related references

Note: Only part of the references are listed.
Article Agriculture, Multidisciplinary

Orientin Attenuated D-GalN/LPS-Induced Liver Injury through the Inhibition of Oxidative Stress via Nrf2/Keap1 Pathway

Fuhua Li et al.

Summary: Orientin, a natural polyphenol with antioxidant capacity, has been shown to ameliorate liver injury induced by D-GalN/LPS by suppressing oxidative stress and activating the Nrf2/ARE pathway.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Article Chemistry, Applied

Structure elucidation and antitumor activity of a water soluble polysaccharide from Hemicentrotus pulcherrimus

Yan Jiang et al.

Summary: A polysaccharide (HPP-1S) extracted from sea urchin gonads showed potential as a low toxic antitumor agent. It induced apoptosis in Hela cells and exhibited significant antitumor efficacy in nude mice.

CARBOHYDRATE POLYMERS (2022)

Article Pharmacology & Pharmacy

CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes

Yan Yang et al.

Summary: The study demonstrated that Cx43 could alleviate renal fibrosis in diabetic mice by activating the Nrf2 pathway, while CKIP-1 was found to play a crucial role in regulating this process. The interaction between Cx43 and CKIP-1, as well as their effects on Nrf2 signaling pathway, were investigated to provide experimental basis for potential therapeutic targets in diabetic renal fibrosis.

PHARMACOLOGICAL RESEARCH (2021)

Article Chemistry, Applied

Study on a novel spherical polysaccharide from Fructus Mori with good antioxidant activity

Yu-Hao Dong et al.

Summary: MFP1P, a novel polysaccharide isolated from Fructus Mori, demonstrated excellent antioxidant activity with a molecular weight of 56.78 kDa and a sugar content of 93.32%.

CARBOHYDRATE POLYMERS (2021)

Review Biochemistry & Molecular Biology

The water-soluble non-starch polysaccharides from natural resources against excessive oxidative stress: A potential health-promoting effect and its mechanisms

Xianxiang Chen et al.

Summary: Water-soluble non-starch polysaccharides isolated from natural resources have garnered significant attention in the field of food science and human health due to their wide distribution in nature and low toxicity. Studies have shown that these polysaccharides play a role in combating excessive oxidative stress in the body, which is associated with various diseases. By scavenging free radicals, promoting antioxidant enzyme activity, and regulating antioxidant signaling pathways, these polysaccharides exhibit antioxidant effects and have potential therapeutic applications in disease treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Biochemistry & Molecular Biology

Black mulberry (Morus nigra L.) polysaccharide ameliorates palmitate-induced lipotoxicity in hepatocytes by activating Nrf2 signaling pathway

Wei Chen et al.

Summary: BP1 polysaccharide fraction isolated from black mulberry shows a better protective effect against lipotoxicity, and it can reduce lipotoxicity by activating the Nrf2 signaling pathway.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Review Food Science & Technology

Hydrogen Peroxide Effects on Natural-Sourced Polysacchrides: Free Radical Formation/Production, Degradation Process, and Reaction Mechanism-A Critical Synopsis

Chigozie E. Ofoedu et al.

Summary: Reactive oxygen species, particularly hydrogen peroxide, play a key role in generating harmful free radicals that can cause cellular damage, leading to various diseases. Polysaccharides from natural sources, despite limitations in bioactivity, have gained attention for their potential as functional ingredients. Degradation of polysaccharides can improve their functionality and bioactivity, particularly in the presence of free radicals such as H2O2.

FOODS (2021)

Article Immunology

Untargeted lipidomics analysis of Mori Fructus polysaccharide on acute alcoholic liver injury in mice using ultra performance liquid chromatography-quadrupole-orbitrap-high resolution mass spectrometry

Liang Bian et al.

Summary: Mori Fructus polysaccharide (MFP) can treat acute alcoholic liver injury by regulating various lipid metabolic pathways, which can help improve the pathological changes in the liver.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Bioactive Phytochemicals from Mulberry: Potential Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

Dahae Lee et al.

Summary: The study evaluated the anti-inflammatory effects of compounds from white mulberry fruits in mouse RAW 264.7 macrophages. Compound cyclo(L-Pro-L-Val) (5) was identified as a potential therapeutic agent for inflammation-associated disorders as it significantly suppressed phosphorylations and activations of inflammatory mediators.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Gastroenterology & Hepatology

Chronic liver disease and oxidative stress - a narrative review

Sophia Seen

Summary: Oxidative stress plays a crucial role in the pathophysiology of chronic liver diseases, and the review emphasizes the potential benefits of antioxidant supplementation in improving liver function, reversing fibrosis, and supporting antiviral therapies. Individual characteristics and genotypes are important factors that can influence the efficacy of antioxidants in chronic liver disease treatment. More research is needed to establish the safety, efficacy, and optimal patient profile for antioxidant treatment.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Biochemistry & Molecular Biology

Structural characterization, modification and hepatoprotective effects of polysaccharide from Mori Fructus

Qingfang Deng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Biochemistry & Molecular Biology

Study on the activity of Mori Fructus polysaccharides and its derivatives against acute alcoholic liver injury in mice

Xi Tan et al.

Summary: Four polysaccharides were isolated from Mori Fructus using DEAE-52 cellulose chromatography and sulfated to obtain sulfated polysaccharides. These polysaccharides showed excellent activities to activate alcohol dehydrogenase in vitro, with MFPA1 exhibiting the strongest anti-acute alcoholic liver injury activity in mouse experiments. These findings suggest the potential therapeutic use of Mori Fructus polysaccharides against acute alcoholic liver injury.

JOURNAL OF CARBOHYDRATE CHEMISTRY (2020)

Review Forestry

Mulberry (Morus spp.): An ideal plant for sustainable development

Gulab Khan Rohela et al.

TREES FORESTS AND PEOPLE (2020)

Article Pharmacology & Pharmacy

ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway

Hao Yan et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)

Review Food Science & Technology

Mulberry: A review of bioactive compounds and advanced processing technology

Peng Wen et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2019)

Article Biochemistry & Molecular Biology

Preparation and antioxidant activities of important traditional plant polysaccharides

Yang Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Review Agriculture, Multidisciplinary

The Mulberry (Morus alba L.) Fruit-A Review of Characteristic Components and Health Benefits

Qingxia Yuan et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

The PI3K AKT pathway in the pathogenesis of prostate cancer

Xiaofei Wen

Frontiers in Bioscience-Landmark (2016)

Article Biochemistry & Molecular Biology

Characterization, antioxidant and immunomodulatory activities of polysaccharides from Prunella vulgaris Linn

Chao Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

Review Biochemistry & Molecular Biology

Oxidative stress and autophagy: the clash between damage and metabolic needs

G. Filomeni et al.

CELL DEATH AND DIFFERENTIATION (2015)

Review Neurosciences

Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke

Alessio Alfieri et al.

JOURNAL OF PHYSIOLOGY-LONDON (2011)

Review Biochemistry & Molecular Biology

Thiol chemistry in peroxidase catalysis and redox signaling

Alberto Bindoli et al.

ANTIOXIDANTS & REDOX SIGNALING (2008)

Review Biochemistry & Molecular Biology

The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

T Nguyen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2004)