Ultrasound combined with nanomaterials for cancer therapy

Ultrasound (US) is considered as a secure external stimulation for different biomedical applications because it is non-invasive, non-toxic and it brings no radiation pollution. Compared with traditional ultrasonography application, US has now attracted more and more attention for cancer therapy. It treats cancer in deeper tissues because it penetrates far than light does. New types of nanomaterials have been developed for US triggered cancer therapy. The study on emerging cancer therapeutic modality triggered by US is also increasing, e.g., high intensity-focused ultrasound (HIFU) therapy, sonodynamic therapy (SDT), and US-mediated drug delivery. The research on current advances in nanomaterials-based and US -triggered cancer treatments have been discussed in detail in this review, especially the underlying mechanisms for better therapeutic effectiveness. Furthermore, challenges and prospective in the evo-lution of nanomaterials for the US-based cancer therapy fields were also explained. It is anticipated that our manifestation in this expanding discipline will aid in the advancement of US-based basic research and therapeutic applications.(c) 2022 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

Ultrasound is a safe external stimulation method that is non-invasive, non-toxic, and free from radiation pollution, making it ideal for various biomedical applications. Its ability to penetrate deep tissues makes it increasingly attractive for cancer therapy. The development of nanomaterials and the study of emerging cancer therapeutic modalities triggered by ultrasound, such as high intensity-focused ultrasound therapy, sonodynamic therapy, and US-mediated drug delivery, are also on the rise.