Targeting ROS-sensitive TRP ion channels for relieving oxidative stress-related diseases based on nanomaterials

Reactive oxygen species (ROS) play an important role in regulating various physiological functions by activating specific ion channels to mediate cell growth, proliferation, regeneration, and apoptosis. ROS sensitive ion channels in the transient receptor potential (TRP) channel family are closely related to oxidative stress-related diseases. Therefore, it is of great significance to regulate ROS levels and their related ion channels. This review summarizes the role of five ROS sensitive ion channels, transient re-ceptor potential M2 (TRPM2), transient receptor potential A1 (TRPA1), transient receptor potential V1 (TRPV1), transient receptor potential M7 (TRPM7) and transient receptor potential C5 (TRPC5), in oxidative stress-related diseases. In addition, the recent research progress of using nanomaterials to regulate oxidative stress-related diseases by targeting ROS-sensitive ion channels is summarized. It is hoped that this review will provide insights for researchers to regulate ROS-sensitive ion channels to alleviate related diseases.(c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

This review summarizes the role of five ROS sensitive ion channels, TRPM2, TRPA1, TRPV1, TRPM7, and TRPC5, in oxidative stress-related diseases, and summarizes the recent research progress of using nanomaterials to regulate oxidative stress-related diseases by targeting ROS-sensitive ion channels.