☆ 4.8 Article

Recent progress of antibacterial hydrogels in wound dressings

MATERIALS TODAY BIO (2023)

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Study on repair of abdominal wall defect rats with hernia mesh coated with chitosan-based photosensitive hydrogel

Huiwen Hu et al.

Summary: This study synthesized hydroxypropyl chitosan azide and applied it as a hydrogel coating on a polypropylene mesh. The hydrogel exhibited excellent biocompatibility and biodegradability, and adhered well to the mesh. During the 180-day follow-up period, the coated mesh promoted wound healing by stimulating the secretion of transforming growth factor-beta1. The coated mesh also showed improved fibrin lysozyme activity and reduced intraperitoneal adhesion compared to the uncoated mesh.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Applied

Development of PVA/Chitosan-g-Poly (N-vinyl imidazole)/TiO2/curcumin nanofibers as high-performance wound dressing

Hamidreza Motasadizadeh et al.

Summary: A novel wound healing system with multifunctional properties was prepared in this study, showing excellent mechanical, structural, and biological properties. The CS-g-PNVIM-based nanofibers exhibited promising potential for biocompatible antibacterial wound dressing applications.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Physical

Nanocomposite conductive tough hydrogel based on metal coordination reinforced covalent Pluronic F-127 micelle network for human motion sensing

Heyuan Huang et al.

Summary: In this study, a conductive tough hydrogel was synthesized by innovatively introducing metal coordination in covalently crosslinked Pluronic F-127 micelle network and combining it with covalent crosslinking and silver nanowire reinforcement. The hydrogel exhibited anti-fatigue, high sensitivity, strong mechanical property, and good sterilization performance.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Nanoscience & Nanotechnology

Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

Yuqing Liang et al.

Summary: This article introduces a multifunctional hydrogel adhesive prepared by a bioinspired dynamic bond cross-linking method, which can be used for seamless wound closure and wound healing. The hydrogel has sufficient mechanical and adhesive strength, as well as injectability and self-healing capacity, which can effectively close wounds and repeatedly close reopened wounds. In addition, it also has good biocompatibility, antibacterial activity, and hemostatic effect.

NANO-MICRO LETTERS (2022)

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Article Chemistry, Multidisciplinary

Coacervate-Derived Hydrogel with Effective Water Repulsion and Robust Underwater Bioadhesion Promotes Wound Healing

Xin Peng et al.

Summary: This study reports a coacervate-to-hydrogel strategy to enhance the water repulsion and adhesion ability of bioadhesives. The deposition of polyethyleneimine/thioctic acid (PEI/TA) coacervate onto underwater substrates effectively repels interfacial water and transforms into a hydrogel within minutes, resulting in enhanced adhesion. The coacervate-to-hydrogel strategy has the advantages of adaptability, strong interfacial adhesion, and robust bulk adhesion, showing potential for diverse biomedical applications.

ADVANCED SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Chemical strategies to engineer hydrogels for cell culture

Junzhe Lou et al.

Summary: Two-dimensional and three-dimensional cell culture systems are widely used for biological studies. This review highlights the use of hydrogels as biomaterials to mimic the natural extracellular matrix and presents recent advances in engineering hydrogels using biocompatible strategies and stimuli-responsive chemistries to control the cellular environment. Future opportunities for engineering hydrogels are also discussed.

NATURE REVIEWS CHEMISTRY (2022)

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Article Engineering, Biomedical

Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing

Chen-Yu Zou et al.

Summary: Bio-adhesive polysaccharide-based hydrogels with improved mechanical properties and bio-adhesion have been developed. These hydrogels exhibit excellent biocompatibility, antibacterial property and pro-healing bioactivity. They show superior hemostatic performance and promote infected wound healing due to their enhanced adhesive properties and procoagulant activity.

BIOACTIVE MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing

Zhipeng Ni et al.

Summary: This study successfully utilized hydrogels containing tannic acid and ROS-responsive components to inhibit bacterial infection and oxidative stress in wounds, accelerating wound healing.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Environmental

An injectable, adhesive, and self-healable composite hydrogel wound dressing with excellent antibacterial activity

Tian Hu et al.

Summary: In this study, an injectable multifunctional hydrogel incorporating fusiform-like zinc oxide nanorods into carboxymethyl chitosan was synthesized. The hydrogel exhibited quick self-healing, good tissue adhesion, and fast hemostasis capabilities. Additionally, it demonstrated excellent antibacterial properties. In a full-thickness skin defect experiment, the hydrogel fit well to the wound geometries and released antibacterial zinc ions slowly and sustainably, promoting wound healing and reducing inflammation significantly.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Environmental

Gradual hydrogel degradation for programable repairing full-thickness skin defect wound

Chao Zhou et al.

Summary: Full-thickness skin defect wound infection is a serious threat to the life and health of patients. In this study, a new type of antibacterial agent was designed, and a wound dressing with angiogenesis-promoting properties was fabricated using a click reaction. The experimental results demonstrated that the dressing exhibited fast antibacterial activity and could reduce inflammation, promote angiogenesis, and accelerate wound healing.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Multidisciplinary

Design the molecule structures to achieve functional advantages of hydrogel wound dressings: Advances and strategies

Ziyuan Zeng et al.

Summary: Wound healing and management are of great concern globally. Hydrogel wound dressings, with their unique characteristics of 3D cross-linked hydrophilic networks, have high water retention capabilities and can create a moist and breathable microenvironment, thereby aiding in wound healing. However, a comprehensive evaluation of hydrogel wound dressings based on polymer chain structures has not been reported. This review provides an introduction to the physiological process of wound healing, summarizes various hydrogel wound dressings, and discusses their design strategies, current challenges, and future directions.

COMPOSITES PART B-ENGINEERING (2022)

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Article Engineering, Multidisciplinary

A multifunctional nanofiber reinforced photo-crosslinking hydrogel for skin wound healing

Fan Yu et al.

Summary: In this study, a multifunctional nanofiber reinforced photo-crosslinking hydrogel wound dressing based on natural biomaterials was developed. The wound dressing mimics the structure and components of the native extracellular matrix (ECM). It exhibited excellent antibacterial effect, antioxidant property, and printability through 3D printing. Furthermore, it promoted angiogenesis, re-epithelialization, and wound healing when applied to full-thickness skin defects.

COMPOSITES PART B-ENGINEERING (2022)

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Article Materials Science, Biomaterials

Advanced antifouling and antibacterial hydrogels enabled by controlled thermo-responses of a biocompatible polymer composite

Fei Pan et al.

Summary: A hydrogel made of PNIPAM-co-PMPC was designed for controlled drug release and antifouling properties, which showed 25-fold more release of octenidine, an antimicrobial agent, at infected wound temperature compared to normal skin temperature. The hydrogel also displayed distinctive antifouling properties against proteins, mammalian cells, and bacteria. This promising design of a hydrogel can be applied for preventing and treating wound infections, as well as other clinical applications related to biofilm-associated infections.

BIOMATERIALS SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Recent developments of sonodynamic therapy in antibacterial application

Ruhao Wang et al.

Summary: The rapid emergence of pathogenic bacteria poses a serious threat to global health, and traditional antibiotic therapies are at risk of strengthening bacterial drug resistance. Sonodynamic therapy (SDT) combining sonosensitizers and low-intensity ultrasound has opened up a new way to treat drug-resistant bacteria, with excellent penetration, favorable biocompatibility, and specific targeting ability.

NANOSCALE (2022)

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Review Materials Science, Biomaterials

Construction of multifunctional wound dressings with their application in chronic wound treatment

Linyu Long et al.

Summary: This review summarizes the progress and research experience of multifunctional wound dressings in the treatment of chronic wounds in recent years, analyzes the functions of these dressings in anti-inflammatory, antioxidant, antibacterial, pro-angiogenic, and tissue adhesive, and discusses in detail the responsive mechanisms of smart multifunctional wound dressings.

BIOMATERIALS SCIENCE (2022)

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Article Materials Science, Biomaterials

Responsive hydrogel-based microneedle dressing for diabetic wound healing

Zhaoyang Guo et al.

Summary: In this study, a glucose-responsive insulin-releasing hydrogel microneedle dressing was developed for diabetic wound healing. The microneedle dressing exhibited mechanical stability, biocompatibility, glucose-responsive insulin release, and improved blood glucose control, making it effective for diabetic wound management and potentially useful for other chronic skin injuries.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Review Chemistry, Multidisciplinary

Organic photosensitizers for antimicrobial phototherapy

Van-Nghia Nguyen et al.

Summary: Microbial infectious diseases, especially those caused by new and antibiotic-resistant bacteria, pose a significant threat to global human health. Phototherapy, as an antibiotic-free treatment, shows promise in treating microbial infections due to its selectivity, non-invasiveness, minimal side effects, and broad antimicrobial activity. This tutorial review provides an overview of the concept and significance of phototherapy, as well as recent research progress in using organic photosensitizers for antimicrobial applications.

CHEMICAL SOCIETY REVIEWS (2022)

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Article Materials Science, Biomaterials

Facile preparation of a thermosensitive and antibiofouling physically crosslinked hydrogel/powder for wound healing

Xiaoru Dong et al.

Summary: In this study, a hydroxybutyl chitosan and poly(sulfobetaine methacrylate) composite hydrogel with thermosensitivity, self-healing, antibiofouling, and synergistic antibacterial activity was prepared. The hydrogel showed promising application in postoperative anti-adhesion and healing of infected wounds.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Chemistry, Physical

Nanocomposite conductive tough hydrogel based on metal coordination reinforced covalent Pluronic F-127 micelle network for human motion sensing

Heyuan Huang et al.

Summary: The study successfully innovated the design of conductive hydrogels by combining metal coordination and silver nanowire reinforcement technologies, resulting in materials with high tensile strength, toughness, and fatigue life, while exhibiting good cytocompatibility and antibacterial performance.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Engineering, Biomedical

Construction of multifunctional porcine acellular dermal matrix hydrogel blended with vancomycin for hemorrhage control, antibacterial action, and tissue repair in infected trauma wounds

D. Cai et al.

Summary: The study developed a dermal extracellular matrix hydrogel loaded with vancomycin as a novel approach for treating skin defects and controlling hemorrhage, showing rapid release of antimicrobial agents, promotion of wound healing, and effective antibacterial and hemostatic effects in in vivo experiments.

MATERIALS TODAY BIO (2021)

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Article Nanoscience & Nanotechnology

Conductive, Self-Healing, Adhesive, and Antibacterial Hydrogels Based on Lignin/Cellulose for Rapid MRSA-Infected Wound Repairing

Pengpeng Deng et al.

Summary: This study developed multifunctional hydrogels based on lignin and cellulose, exhibiting excellent physical and biological properties for treating infected wounds and promoting wound healing.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Injectable, Intrinsically Antibacterial Conductive Hydrogels with Self-Healing and pH Stimulus Responsiveness for Epidermal Sensors and Wound Healing

Ling Fan et al.

Summary: This study developed a chitosan-based hydrogel with self-healing, conductive, and antibacterial properties, which can be used as a sensor to monitor human health in real-time and promote wound healing. The injectable hydrogel, fabricated via Schiff base linkage and hydrogen bond, shows pH responsiveness and broad-spectrum antibacterial properties.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

Aziz Maleki et al.

Summary: Light-based photothermal therapy (PTT) and photo-dynamic therapy (PDT) have great potential in wound healing and infection prevention. Multifunctional photoresponsive hydrogels (MPRHs) combining light and hydrogel advantages are increasingly used in biomedicine, particularly in wound repair. The modulation of bacterial microenvironments to inhibit infection through PTT, PDT, and photothermal/photodynamic synergistic therapy has been discussed.

ACS NANO (2021)

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Article Engineering, Environmental

To decipher the antibacterial mechanism and promotion of wound healing activity by hydrogels embedded with biogenic Ag@ZnO core-shell nanocomposites

Md Imran Khan et al.

Summary: The study developed hydrogels embedded with biogenic Ag@ZnO core-shell nanocomposites for wound healing applications in a mouse model. The hydrogels showed remarkable antibacterial activity and high biocompatibility, effectively targeting S. aureus, MRSA, and P. aeruginosa while improving wound healing efficacy in the mouse model. It suggests the potential of the synthesized hydrogels dressing system to enhance wound healing rate in different physiological surroundings.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Applied

Multifunctional chitin-based barrier membrane with antibacterial and osteogenic activities for the treatment of periodontal disease

Tao Wu et al.

Summary: The study developed a chitin hydrogel containing zinc oxide nanoparticles with antibacterial and osteogenic activities, demonstrating significant repair effects in an animal model.

CARBOHYDRATE POLYMERS (2021)

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Article Biochemistry & Molecular Biology

In vitro and in vivo evaluation of gellan gum hydrogel films: Assessing the co impact of therapeutic oils and ofloxacin on wound healing

Huma Mahmood et al.

Summary: The study reported the co-encapsulation of ofloxacin with tea tree or lavender oil in gellan gum based hydrogel films using the solvent casting ionotropic gelation method, showing superior antibacterial and wound healing activity. In vitro release studies demonstrated controlled release of the drug and oils from the films over 48 hours.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Engineering, Multidisciplinary

N-halamine modified ceria nanoparticles: Antibacterial response and accelerated wound healing application via a 3D printed scaffold

Zhenming Yang et al.

Summary: In this study, a novel three-dimensional printed dressing with significant antibacterial activity and biocompatibility was fabricated using gelatin methacryloyl (GelMA) and a photocrosslinking technique, with CeO2/N-halamine hybrid nanoparticles playing a key role in antibacterial effects. The dressing exhibited excellent swelling efficiency and blood-clotting ability, and in vivo experiments showed that it efficiently accelerated wound closure by promoting tissue regeneration.

COMPOSITES PART B-ENGINEERING (2021)

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Article Pharmacology & Pharmacy

Hybrid hydrogels for bacteriocin delivery to infected wounds

Raj Kumar Thapa et al.

Summary: Superficial infections in chronic wounds can hinder the wound healing process by causing persistent infections and drug-resistant biofilms. Topically applied antimicrobial formulations, such as bacteriocins, offer significant benefits for treating wound infections effectively. The developed GarKS gel showed controlled release behavior for up to 9 days, with potent antibacterial and anti-biofilm effects against Staphylococcus aureus, indicating its potential for successful treatment of wound infections.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing

Jingfeng Yuan et al.

Summary: A cationic peptide-based, salt-responsive hydrogel dressing with triple functions of antifouling, bactericidal, and bacterial release was developed, demonstrating high antibacterial activity, biocompatibility, and cell proliferation efficacy.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities

Muhammad Umar Aslam Khan et al.

Summary: The research explored the potential of composite hydrogels based on ARX, CS, and rGO for wound dressing in skin wound healing, demonstrating their excellent antibacterial properties and controlled drug release capabilities. The hydrogels showed pH sensitivity and maximum drug release at pH 7.4 and 37 degrees C, making them promising biomaterials for treating and caring for skin wounds.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Engineering, Biomedical

Thermo-Triggered In Situ Chitosan-Based Gelation System for Repeated and Enhanced Sonodynamic Therapy Post a Single Injection

Jialin She et al.

Summary: The thermo-triggered in situ hydrogel system enhances the efficacy of sonodynamic therapy by reversing the oxygen-deficient status in solid tumors, offering robust treatment effects to effectively eradicate tumors.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Engineering, Biomedical

Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities

Hao Cheng et al.

Summary: The study introduces a novel sprayable hydrogel wound dressing loaded with cerium oxide nanoparticles and an antimicrobial peptide, providing ROS-scavenging and antibacterial properties. By adopting a mussel-inspired strategy, the hydrogel exhibited improved binding affinity to wet skin surfaces and demonstrated excellent biocompatibility.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Silk-Inspired In Situ Hydrogel with Anti-Tumor Immunity Enhanced Photodynamic Therapy for Melanoma and Infected Wound Healing

Xiaoxuan Tang et al.

Summary: A silk-based hydrogel system has been developed for improved cancer therapy and enhanced wound healing, showing promising results in suppressing tumor recurrence and promoting tissue regeneration.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Nanogel Encapsulated Hydrogels: Nanogel Encapsulated Hydrogels As Advanced Wound Dressings for the Controlled Delivery of Antibiotics (Adv. Funct. Mater. 7/2021)

Yanmiao Fan et al.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Injectable Self-Healing Hydrogel Wound Dressing with Cysteine-Specific On-Demand Dissolution Property Based on Tandem Dynamic Covalent Bonds

Xiaoya Ding et al.

Summary: An injectable self-healing hydrogel with rapid gelation and cysteine-specific on-demand dissolution was designed for wound dressings, showing excellent injectability, self-healing ability, and rapid cysteine-triggered dissolution. The hydrogel displayed favorable biocompatibility, achieved rapid wound closure in seconds, and fast on-demand dissolution for dressing changes, highlighting its potential for wound healing applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Applied

Hydroxypropyl methylcellulose-copper nanoparticle and its nanocomposite hydrogel films for antibacterial application

Tippabattini Jayaramudu et al.

Summary: This study focuses on the design and fabrication of antibacterial nanocomposite hydrogels for wound dressing applications, with particular emphasis on HCu NPs incorporated HPMC NHFs. The antibacterial activity of the NHFs against S. aureus and E. coli was demonstrated, suggesting their effectiveness for antibacterial applications.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Applied

Novel porous chitosan/N-halamine structure with efficient antibacterial and hemostatic properties

Yuxia Zheng et al.

Summary: A novel chitosan-based structure, CS/EVC, prepared with EVC as a cross-linker, showed excellent antibacterial activities by inactivating Staphylococcus aureus and Escherichia coli. The CS/EVC/MC also demonstrated the potential to promote blood cell agglutination, control wound bleeding, and had no cytotoxicity, making it a promising material for biomedical applications.

CARBOHYDRATE POLYMERS (2021)

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Article Engineering, Environmental

Dual cross-linked organic-inorganic hybrid hydrogels accelerate diabetic skin wound healing

Yuna Qian et al.

Summary: Limited treatment options are available for chronic non-self-healing diabetic wounds characterized by bacterial infection and hypoxic microenvironment. A multifunctional organic-inorganic hybrid hydrogel, SF/Hb/Ga, was developed to address these challenges. This hybrid hydrogel demonstrated antibacterial properties, promoted cell proliferation, and accelerated tissue repair phases, leading to complete healing of infected diabetic wounds in vivo within 15 days.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Applied

Formation and characterization of calcium alginate hydrogel beads filled with cumin seeds essential oil

Setareh Gholamian et al.

Summary: The preparation and characterization of a novel encapsulation system based on calcium alginate hydrogels filled with cumin essential oil was investigated, demonstrating successful encapsulation and favorable carrier features.

FOOD CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Strong tough hydrogels via the synergy of freeze-casting and salting out

Mutian Hua et al.

Summary: A strategy combining freeze-casting and salting-out treatments produces poly(vinyl alcohol) hydrogels with a multi-length-scale hierarchical architecture, including micrometre-scale honeycomb-like pore walls and interconnected nanofibril meshes. These hydrogels have properties that compare favorably to other tough hydrogels and even natural tendons.

NATURE (2021)

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Article Chemistry, Multidisciplinary

A Mussel-Inspired Antibacterial Hydrogel with High Cell Affinity, Toughness, Self-Healing, and Recycling Properties for Wound Healing

Xueyong Deng et al.

Summary: A novel hydrogel with antibacterial and superior biocompatibility properties was successfully developed in this study, utilizing multiple cross-linking structures and innovative preparation methods. The hydrogel showed potential in preventing bacterial infection and promoting tissue regeneration during wound healing processes.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2021)

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Article Engineering, Biomedical

Antibacterial Zeolite Imidazole Frameworks with Manganese Doping for Immunomodulation to Accelerate Infected Wound Healing

Yao Wan et al.

Summary: A strategy of introducing enzymatic activity into nanomaterials for antibacterial and anti-inflammatory effects is introduced, showing dual functionality for treating bacterial infected wounds. This simple metal organic framework design effectively combines the enzymatic activity of manganese ions with the pore structure advantages of ZIF-8.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Wound Dressing Hydrogel of Enteromorpha prolifera Polysaccharide-Polyacrylamide Composite: A Facile Transformation of Marine Blooming into Biomedical Material

Fei Jiang et al.

Summary: The study has developed a PEP-PAM hydrogel composed of natural macromolecules, demonstrating high mechanical strength and self-healing ability. This hydrogel promotes cell proliferation and wound healing, showing potential as an effective wound dressing material.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Development of Inherently Antibacterial, Biodegradable, and Biologically Active Chitosan/Pseudo-Protein Hybrid Hydrogels as Biofunctional Wound Dressings

Maoli Yin et al.

Summary: The study developed a new family of hydrogel-based wound dressings with antibacterial and biological functionality, without the need for antibiotics, to accelerate wound healing. The hybrid hydrogels showed excellent antibacterial activity, biocompatibility with cells, and potential for biofunctional antibacterial wound dressing candidates.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Epigenetic Remodeling Hydrogel Patches for Multidrug-Resistant Triple-Negative Breast Cancer

Xiaoyuan Ji et al.

Summary: The hydrogel patch designed to modulate the plasticity of T-ICs in TNBC shows promising results in improving chemosensitivity, enhancing tumor immunogenicity, and increasing T-cell infiltration. Additionally, the patch efficiently suppresses tumor growth, postsurgical relapse, and metastasis with a single dose, demonstrating superior efficacy against multidrug resistance.

ADVANCED MATERIALS (2021)

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Article Polymer Science

Facile Preparation of Tunicate-Inspired Chitosan Hydrogel Adhesive with Self-Healing and Antibacterial Properties

Xiang He et al.

Summary: Researchers prepared CS-TBA-Fe hydrogels by mixing chitosan with TBA and FeCl3, showing strong wet tissue adhesion and high biocompatibility. The hydrogel exhibited enhanced wet tissue adhesion strength, robust adhesion to various substrates, controllable physical properties, and antibacterial activity against E. coli.

POLYMERS (2021)

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Article Engineering, Biomedical

A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion

Yang Yuan et al.

Summary: A novel double cross-linked hydrogel prepared by Schiff base and catechol-Fe3+ chelation bond was designed for dynamic burn wounds, showing enhanced physicochemical properties and efficacy, suitable for wounds with irregular shapes.

BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Translational Applications of Hydrogels

Santiago Correa et al.

Summary: Advances in hydrogel technology have led to diverse applications in medicine and environmental engineering, providing solutions for various diseases and medical conditions. Collaboration across disciplines is essential for the development of contemporary hydrogels to accomplish complex biological tasks in different fields.

CHEMICAL REVIEWS (2021)

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Article Biophysics

Poly(aspartic acid) based self-healing hydrogels with antibacterial and light-emitting properties for wound repair

Jiafu Shen et al.

Summary: This study introduces a self-healing hydrogel with antibacterial and light-emitting properties for wound repair. By utilizing the dynamic nature of boronic ester bonds, bacteria-killing activity of quaternary ammonium, and light-emitting activity of phenylboronic ester, the hydrogels demonstrated promising results in controlled release of mouse epidermal growth factor (mEGF) and accelerating wound repair in vivo. These PASP based hydrogels show great potential for bio-applications, particularly in wound dressing and tissue repairing.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Engineering, Biomedical

Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment

Yuxuan Yang et al.

Summary: In this study, a bioactive skin-mimicking hydrogel band-aid was developed to promote the recovery of skin incision and defects on diabetic mice. The hydrogel showed promising anti-inflammation, antibacterial, and antioxidant properties, as well as moisture-resistant adhesiveness.

BIOACTIVE MATERIALS (2021)

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Article Acoustics

Antibacterial mechanism of ultrasound against Escherichia coli: Alterations in membrane microstructures and properties

Qiao He et al.

Summary: This study explored the response of bacterial cell membranes to ultrasound exposure. It was found that ultrasonic treatment resulted in a significant reduction in E. coli populations and increased sensitivity to antimicrobial compounds. Additionally, ultrasonic-treated cells showed membrane damages and increased membrane permeability.

ULTRASONICS SONOCHEMISTRY (2021)

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Article Nanoscience & Nanotechnology

Novel Diabetic Foot Wound Dressing Based on Multifunctional Hydrogels with Extensive Temperature-Tolerant, Durable, Adhesive, and Intrinsic Antibacterial Properties

Hou Liu et al.

Summary: This study developed a temperature-tolerant antibacterial hydrogel dressing with excellent properties, effectively promoting the healing of diabetic foot ulcers (DFUs).

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Inflammation-Responsive Drug-Loaded Hydrogels with Sequential Hemostasis, Antibacterial, and Anti-Inflammatory Behavior for Chronically Infected Diabetic Wound Treatment

Yu Wang et al.

Summary: The study synthesized a dual-responsive hydrogel (pH and ROS) for drug release under inflammatory stimulation. This novel design retained dynamic functions of hydrogels and achieved sequential and on-demand drug delivery at diabetic-infected wound sites.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Yongping Liang et al.

Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Bioinspired Shape Memory Hydrogel Artificial Muscles Driven by Solvents

Yande Cui et al.

Summary: This study presents a simple and effective strategy for designing and fabricating tendril-inspired hydrogel artificial muscles with high actuation rate, large actuation strain, and shape memory property in response to solvents. The actuation performances of hydrogel muscles are influenced by factors such as chirality, twist density, applied stress, and temporary shape, and a homochiral hydrogel muscle shows comparable contractile work capacity with natural muscles, demonstrating great potential for biomedical applications.

ACS NANO (2021)

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Review Pharmacology & Pharmacy

Antimicrobial peptides towards clinical application: Delivery and formulation

Cheng Wang et al.

Summary: This article reviews recent studies on the delivery and formulation of antimicrobial peptides, categorizing strategies driven by physical interactions or chemical conjugation reactions, and covering carriers from inorganic solid nanoparticles to organic micelles, liposomes, and hydrogels. Targeted delivery, responsive release, and strategies to increase oral bioavailability of antimicrobial peptides are discussed, highlighting the recent progress towards clinical application.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Mahshid Kharaziha et al.

Summary: The immune reaction plays a critical role in chronic wound healing, with modulation of macrophages' polarization being an appealing approach in regenerative medicine. The use of hydrogels-based constructs has been recently developed to adjust immune cell functions in various stages of wound healing. The properties of hydrogels have significant effects on immunogenic features and the wound healing process.

ADVANCED MATERIALS (2021)

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Review Chemistry, Physical

Ionic liquid-based antimicrobial materials for water treatment, air filtration, food packaging and anticorrosion coatings

Zari Fallah et al.

Summary: Efforts to broaden the applications of ionic liquids have advanced in the past two decades. Ionic liquids show promise as antimicrobial systems, as they can be tailored in various sizes, morphologies, and surface charges. Common methods for preparing ionic liquid-based materials include crosslinking, loading, grafting, and combining with other polymeric materials. Recent research focuses on tuning the biological properties of these materials for antimicrobial applications in water treatment, air filtration, food packaging, and anticorrosion.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2021)

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Review Microbiology

Antimicrobial Activity of Metals and Metalloids

Yuan Ping Li et al.

Summary: Competition drives evolution, with toxic metals and metalloids exerting selective pressure on life, leading to the evolution of resistance mechanisms in microorganisms. Microorganisms exploit antimicrobial metals to gain competitive advantage, which in turn drives the evolution of resistance mechanisms against these metals and metalloids.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021 (2021)

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Article Chemistry, Applied

Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility

De-qiang Li et al.

Summary: A self-healing pectin/chitosan hydrogel with pH-responsiveness was prepared in this study, greatly improving its performance through the Diels-Alder reaction and showing excellent self-healing capability and cytocompatibility.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Applied

A double-network polysaccharide-based composite hydrogel for skin wound healing

Yuxin He et al.

Summary: The double-network polysaccharide-based hydrogel showed excellent mechanical properties, biological activities, and biocompatibility, effectively promoting wound healing. Experimental results demonstrated that the hydrogel accelerated wound healing in a mouse skin defect model through multiple pathways.

CARBOHYDRATE POLYMERS (2021)

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Article Engineering, Environmental

Ionic liquid functionalized non-releasing antibacterial hydrogel dressing coupled with electrical stimulation for the promotion of diabetic wound healing

Pan Liu et al.

Summary: A multifunctional and conductive hydrogel dressing developed in this study based on polymerized ionic liquid and konjac glucomannan showed excellent mechanical properties, biocompatibility, and an efficient sterilization effect. When combined with electrical stimulation, it significantly improved fibroblast cell migration and proliferation, as well as the treatment effect on diabetic skin wounds, providing a novel strategy for efficiently treating chronic wounds.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Multidisciplinary

Structurally Dynamic Hydrogels for Biomedical Applications: Pursuing a Fine Balance between Macroscopic Stability and Microscopic Dynamics

Kunyu Zhang et al.

Summary: Hydrogels are gaining increasing attention in biomedical studies due to their unique chemical and physical properties. Dynamic hydrogels, which can better mimic the functions of natural extracellular matrix, have shown promise in applications such as regenerative medicine and drug delivery. Recent research has focused on the fabrication strategies and unique properties of dynamic hydrogels, as well as discussing challenges and emerging trends in their development and application.

CHEMICAL REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Facile Synthesis of the Cu, N-CDs@GO-CS Hydrogel with Enhanced Antibacterial Activity for Effective Treatment of Wound Infection

Mingqian Wang et al.

Summary: The study demonstrates the use of Cu, N-CDs@GO-CS hydrogels for effective antibacterial treatment under near-infrared laser irradiation, showing superior antibacterial activity against Staphylococcus aureus and Escherichia coli. Application of the hydrogels on wounds in mice results in favorable wound healing outcomes and protection against secondary infection without significant harmful side effects to major organs.

LANGMUIR (2021)

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Review Materials Science, Biomaterials

Advances in versatile anti-swelling polymer hydrogels

Yiwei Zhan et al.

Summary: Traditional hydrogels tend to swell, leading to mechanical property deterioration and undesired pressure on surrounding tissues when applied. In contrast, anti-swelling hydrogels maintain their original mechanical performance and size stability when applied in aqueous environments. Researchers have developed various anti-swelling hydrogels with versatile functions in recent years, integrating anti-swelling property with characteristics like high strength, self-healing, injectability, adhesiveness, and antibacterial properties.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Multidisciplinary

Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo

Zoran Kokan et al.

Summary: This study presents a hydrogel system based on the bambus[6]uril anion receptor, which can selectively form hydrogels in the presence of specific ions. The gelation mechanism and network structure were elucidated through various methods, and it was found that slow drug release can be achieved in physiological saline solutions.

CHEM (2021)

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Review Engineering, Biomedical

Antibacterial metals and alloys for potential biomedical implants

Erlin Zhang et al.

Summary: Metals and alloys, such as stainless steel, titanium, cobalt alloys, have been widely used as implant materials, but implant-related infection or inflammation remains a major cause of implantation failure. Antimicrobial metals and alloys have recently attracted attention for their stable antimicrobial ability, good mechanical properties, and biocompatibility, showing promise for clinical applications.

BIOACTIVE MATERIALS (2021)

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Review Medicine, General & Internal

Antimicrobial peptides: mechanism of action, activity and clinical potential

Qi-Yu Zhang et al.

Summary: Antimicrobial peptides (AMPs) are a promising candidate to combat antibiotic resistant bacteria, showing broad-spectrum antimicrobial activity with low toxicity and utilizing sophisticated mechanisms of action. This comprehensive review provides an overview of the origin, structural characteristics, mechanisms of action, biological activities, and clinical applications of AMPs. Strategies to optimize and develop AMP-based treatments for potential antimicrobial and anticancer therapeutics are also discussed.

MILITARY MEDICAL RESEARCH (2021)

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Review Nanoscience & Nanotechnology

Shape-Memory and Self-Healing Polymers Based on Dynamic Covalent Bonds and Dynamic Noncovalent Interactions: Synthesis, Mechanism, and Application

Zhenlong Li et al.

Summary: Shape-memory and self-healing polymers have been a focus of research in the field of smart polymers in the past decade. These polymers can undergo programed shape transformation under external stimulation and repair damage spontaneously, extending the materials' lifespan. The review analyzes the physical or chemical changes in materials during shape memory and self-healing, classifies polymers, and discusses preparation methods based on dynamic interactions that enable self-healing properties.

ACS APPLIED BIO MATERIALS (2021)

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Article Materials Science, Biomaterials

Conductive dual hydrogen bonding hydrogels for the electrical stimulation of infected chronic wounds

Ye Wu et al.

Summary: A study successfully prepared a tough conductive hydrogel with similar conductivity to human skin and superior mechanical properties. The hydrogel exhibited intense antimicrobial activity, and electrical stimulation via the conductive hydrogel was more effective in healing infected wounds than traditional methods.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

A novel self-healing triple physical cross-linked hydrogel for antibacterial dressing

Dongrun Li et al.

Summary: The mechanical properties of wound dressings have always been a challenge, especially when hydrogel dressings absorb tissue fluid. By incorporating hydrophobic interactions, the mechanical properties of the hydrogel can be improved after water absorption, maintaining good performance. Additionally, introducing ionic liquid promotes self-healing in the hydrogel and enhances antibacterial properties, showing promise for wound healing applications.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

A tough, adhesive, self-healable, and antibacterial plant-inspired hydrogel based on pyrogallol-borax dynamic cross-linking

Chao Ma et al.

Summary: This plant-inspired hydrogel demonstrated high mechanical strength, self-healing properties, excellent adhesion, and good antibacterial activities, making it suitable for applications in biomimetic tissues and biosensors.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Multidisciplinary

An environmentally friendly wound dressing based on a self-healing, extensible and compressible antibacterial hydrogel

Maryam Tavakolizadeh et al.

Summary: The ultra-tough and self-healable double-network hydrogel designed based on salep/poly(vinyl alcohol) demonstrates superior tissue adhesiveness, high mechanical strength, good tissue adhesiveness, and excellent therapeutic properties for wound healing. The self-healing capability is achieved through interactions between oxidized salep and ethylene diamine-modified salep chains, as well as through the hydroxyl groups of the poly(vinyl alcohol) network. In vitro and in vivo tests confirm that this hydrogel could be a promising candidate for skin tissue regeneration in medical applications.

GREEN CHEMISTRY (2021)

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Review Chemistry, Multidisciplinary

Polyphenol scaffolds in tissue engineering

Xueqian Zhang et al.

Summary: Polyphenols are a group of compounds with biocompatible, antioxidant, and antibacterial properties that form strong non-covalent and covalent interactions. This review discusses the structures and functions of polyphenols and their application in wound healing, bone regeneration, and tissue engineering, offering insights for the design and preparation of next-generation polyphenol scaffolds.

MATERIALS HORIZONS (2021)

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Article Chemistry, Physical

Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing

Donald R. Griffin et al.

Summary: The study aimed to slow MAP scaffold degradation by changing the chirality of peptides, but unexpectedly, D-peptide crosslinked MAP scaffolds led to accelerated degradation in vivo, promoting tissue regeneration and enhancing wound healing. D-MAP triggered an immune response against D-chiral peptides and intact adaptive immune system was crucial for skin regeneration induced by the hydrogel.

NATURE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Rapid-Fabricated and Recoverable Dual-Network Hydrogel with Inherently Anti-Bacterial Abilities for Potential Adhesive Dressings

Kun Lei et al.

Summary: The study introduces injectable and recoverable dual-network hydrogels with excellent physicochemical properties and biocompatibility, making them a promising candidate for potential wound dressings. The hydrogels, based on PLL-g-HPA and Aga, exhibit fast gelation time, connective pore structure, good formability, and superior stability in extreme conditions. Additionally, the hydrogels have a helical structure and antibacterial ability, making them suitable for tissue attachment and preventing bacterial infection.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Applied

Simultaneously improved strength and toughness in κ-carrageenan/polyacrylamide double network hydrogel via synergistic interaction

Sijun Liu et al.

CARBOHYDRATE POLYMERS (2020)

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Article Nanoscience & Nanotechnology

Carbon Nanotubes/Hydrophobically Associated Hydrogels as Ultrastretchable, Highly Sensitive, Stable Strain, and Pressure Sensors

Zhihui Qin et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Environmental

A bifunctional hydrogel incorporated with CuS@MoS2 microspheres for disinfection and improved wound healing

Xingyu Zhang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Engineering, Environmental

Engineering a multifunctional N-halamine-based antibacterial hydrogel using a super-convenient strategy for infected skin defect therapy

Wanjun Chen et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Biochemistry & Molecular Biology

Zn2+-loaded TOBC nanofiber-reinforced biomimetic calcium alginate hydrogel for antibacterial wound dressing

Minghao Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Nanoscience & Nanotechnology

Novel Metal-Organic Framework-Based Photocrosslinked Hydrogel System for Efficient Antibacterial Applications

Kihak Gwon et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Biochemistry & Molecular Biology

Injectable Antimicrobial Conductive Hydrogels for Wound Disinfection and Infectious Wound Healing

Yongping Liang et al.

BIOMACROMOLECULES (2020)

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Article Chemistry, Applied

Thermosensitive and pH-responsive tannin-containing hydroxypropyl chitin hydrogel with long-lasting antibacterial activity for wound healing

Mengsi Ma et al.

CARBOHYDRATE POLYMERS (2020)

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Review Chemistry, Applied

Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review

Arash Moeini et al.

CARBOHYDRATE POLYMERS (2020)

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Review Biochemistry & Molecular Biology

The Science of Antibiotic Discovery

Kim Lewis

CELL (2020)

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Review Polymer Science

Status and future scope of hydrogels in wound healing: Synthesis, materials and evaluation

Jinxi Xiang et al.

EUROPEAN POLYMER JOURNAL (2020)

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Article Engineering, Biomedical

Antibacterial, Cytocompatible, Sustainably Sourced: Cellulose Membranes with Bifunctional Peptides for Advanced Wound Dressings

Ramon Weishaupt et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Antimicrobial Metal Nanomaterials: From Passive to Stimuli-Activated Applications

Samuel Cheeseman et al.

ADVANCED SCIENCE (2020)

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Article Nanoscience & Nanotechnology

Multifunctional Tissue-Adhesive Cryogel Wound Dressing for Rapid Nonpressing Surface Hemorrhage and Wound Repair

Meng Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

PDA/Cu Bioactive Hydrogel with Hot Ions Effect for Inhibition of Drug-Resistant Bacteria and Enhancement of Infectious Skin Wound Healing

Qing Xu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Biocompatible In Situ Polymerization of Multipurpose Polyacrylamide-Based Hydrogels on Skin via Silver Ion Catalyzation

Haifeng Ji et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Environmental

Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds

Jiahui He et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Review Biochemistry & Molecular Biology

Natural Polymer-Based Antimicrobial Hydrogels without Synthetic Antibiotics as Wound Dressings

Yajie Zhong et al.

BIOMACROMOLECULES (2020)

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Article Chemistry, Applied

Supramolecular hydrogels based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties

Oscar Forero-Doria et al.

CARBOHYDRATE POLYMERS (2020)

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Article Biochemistry & Molecular Biology

Continuous production of antibacterial carboxymethyl chitosan-zinc supramolecular hydrogel fiber using a double-syringe injection device

Yu-Long Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Doubly crosslinked biodegradable hydrogels based on gellan gum and chitosan for drug delivery and wound dressing

Xiaomin Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Nanoscience & Nanotechnology

Highly Absorbent Antibacterial and Biofilm-Disrupting Hydrogels from Cellulose for Wound Dressing Applications

Mandana Tavakolian et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Antibacterial Zwitterionic Polyelectrolyte Hydrogel Adhesives with Adhesion Strength Mediated by Electrostatic Mismatch

Jintao Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Dissolvable Microneedles Coupled with Nanofiber Dressings Eradicate Biofilms via Effectively Delivering a Database-Designed Antimicrobial Peptide

Yajuan Su et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Synthetic Polymeric Antibacterial Hydrogel for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing: Nanoantimicrobial Self-Assembly, Drug- and Cytokine-Free Strategy

Wenshuai Liu et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

An Adhesive Hydrogel with Load-Sharing Effect as Tissue Bandages for Drug and Cell Delivery

Jing Chen et al.

ADVANCED MATERIALS (2020)

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Article Engineering, Environmental

Rapid bacteria trapping and killing of metal-organic frameworks strengthened photo-responsive hydrogel for rapid tissue repair of bacterial infected wounds

Donglin Han et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Review Nanoscience & Nanotechnology

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics

Xin Pang et al.

NANO-MICRO LETTERS (2020)

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Article Chemistry, Applied

Charged group-modified poly(vinyl alcohol) hydrogels: Preparation and antibacterial property

Xu Yang et al.

REACTIVE & FUNCTIONAL POLYMERS (2020)

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Article Chemistry, Multidisciplinary

Synergistic control of dual cross-linking strategy toward tailor-made hydrogels

Xueyu Dou et al.

SCIENCE CHINA-CHEMISTRY (2020)

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Article Materials Science, Biomaterials

Electroresponsive Alginate-Based Hydrogels for Controlled Release of Hydrophobic Drugs

Anna Puiggali-Jou et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Chemistry, Physical

Two-Pronged Strategy of Biomechanically Active and Biochemically Multifunctional Hydrogel Wound Dressing To Accelerate Wound Closure and Wound Healing

Meng Li et al.

CHEMISTRY OF MATERIALS (2020)

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Article Engineering, Biomedical

Enzyme-mediated one-pot synthesis of hydrogel with the polyphenol cross-linker for skin regeneration

B. S. Kim et al.

MATERIALS TODAY BIO (2020)

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Article Materials Science, Biomaterials

A multifunctional shape-adaptive and biodegradable hydrogel with hemorrhage control and broad-spectrum antimicrobial activity for wound healing

Lingling Gao et al.

BIOMATERIALS SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Novel biocompatible and antimicrobial supramolecular O-carboxymethyl chitosan biguanidine/zinc physical hydrogels

Hend Ezzat Salama et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Chemistry, Applied

Synthesis of nanocomposite hydrogel based carboxymethyl starch/polyvinyl alcohol/nanosilver for biomedical materials

Artjima Ounkaew et al.

CARBOHYDRATE POLYMERS (2020)

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Article Biochemistry & Molecular Biology

Innovation inspired by nature: Biocompatible self-healing injectable hydrogels based on modified-β-chitin for wound healing

Jolleen Natalie I. Balitaan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Chitosan dressings containing inorganic additives and levofloxacin as potential wound care products with enhanced hemostatic properties

Ioanna Koumentakou et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Engineering, Environmental

Injectable self-healing supramolecular hydrogels with conductivity and photo-thermal antibacterial activity to enhance complete skin regeneration

Beilin Zhang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Engineering, Environmental

Biomimetic lignin/poly(ionic liquids) composite hydrogel dressing with excellent mechanical strength, self-healing properties, and reusability

Yiwen Zhang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Materials Science, Biomaterials

A Fe3+-crosslinked pyrogallol-tethered gelatin adhesive hydrogel with antibacterial activity for wound healing

Ning Han et al.

BIOMATERIALS SCIENCE (2020)

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Review Polymer Science

Dynamic covalent bonds in self-healing, shape memory, and controllable stiffness hydrogels

M. Mario Perera et al.

POLYMER CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Wound dressing change facilitated by spraying zinc ions

Tian Xie et al.

MATERIALS HORIZONS (2020)

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Article Chemistry, Physical

Strong dual-crosslinked hydrogels for ultrasound-triggered drug delivery

Wenxu Sun et al.

NANO RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Glucose-sensitive delivery of metronidazole by using a photo-crosslinked chitosan hydrogel film to inhibit Porphyromonas gingivalis proliferation

Junyu Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Materials Science, Biomaterials

Design and performance of sericin/poly(vinyl alcohol) hydrogel as a drug delivery carrier for potential wound dressing application

Gang Tao et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Chemistry, Multidisciplinary

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing

Yongping Liang et al.

SMALL (2019)

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Article Engineering, Environmental

Degradable conductive injectable hydrogels as novel antibacterial, anti-oxidant wound dressings for wound healing

Jin Qu et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Article Engineering, Multidisciplinary

Synthesis of deformable hydrogel composites based on Janus bilayer multi-walled carbon nanotubes/host-guest complex structure

Yun-Fei Zhang et al.

COMPOSITES PART B-ENGINEERING (2019)

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Article Biochemistry & Molecular Biology

Concomitant and controlled release of furazolidone and bismuth(III) incorporated in a cross-linked sodium alginate-carboxymethyl cellulose hydrogel

Klaudia Maria Machado Neves Silva et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Physical

Dendrimer directed assembly of dicarboxylated hairy nanocellulose

Mandana Tavakolian et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Ultrasound-activated microbubbles as a novel intracellular drug delivery system for urinary tract infection

H. Horsley et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Chemistry, Multidisciplinary

Skin-Inspired Antibacterial Conductive Hydrogels for Epidermal Sensors and Diabetic Foot Wound Dressings

Yue Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Polymer Science

Super-tough hydrogels using ionically crosslinked networks

Jilong Wang et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2019)

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Article Materials Science, Biomaterials

Injectable chitosan/β-glycerophosphate hydrogels with sustained release of BMP-7 and ornidazole in periodontal wound healing of class III furcation defects

Shengqi Zang et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Engineering, Biomedical

In situ synthesis of biocompatible imidazolium salt hydrogels with antimicrobial activity

Jingshi Liang et al.

ACTA BIOMATERIALIA (2019)

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Article Engineering, Environmental

Synthesis of a novel anti-freezing, non-drying antibacterial hydrogel dressing by one-pot method

Kang Wang et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Article Chemistry, Physical

Rapid Diels-Alder Cross-linking of Cell Encapsulating Hydrogels

Christopher M. Madl et al.

CHEMISTRY OF MATERIALS (2019)

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Article Biochemistry & Molecular Biology

Characterization of an antibacterial wound dressing from basil seed (Ocimum basilicum L.) mucilage-ZnO nanocomposite

Siriporn Tantiwatcharothai et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Biochemistry & Molecular Biology

Fabrication, characterization and drug loading efficiency of citric acid crosslinked NaCMC-HPMC hydrogel films for wound healing drug delivery applications

K. Dharmalingam et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Physical

Poly (vinyl alcohol) (PVA) hydrogel incorporated with Ag/TiO2 for rapid sterilization by photoinspired radical oxygen species and promotion of wound healing

Jiameng Wang et al.

APPLIED SURFACE SCIENCE (2019)

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Article Cardiac & Cardiovascular Systems

P4499Development of a hydrogel-based pre-vascularized 3D cardiac patch displaying capillary network

L Kitasato et al.

EUROPEAN HEART JOURNAL (2019)

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Editorial Material Medicine, General & Internal

Bioinspired Adhesive Dressing Actively Heals Wounds in Animals

Tracy Hampton

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

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Article Chemistry, Physical

Mussel-inspired, antibacterial, conductive, antioxidant, injectable composite hydrogel wound dressing to promote the regeneration of infected skin

Yongping Liang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Nanoscience & Nanotechnology

Ultrastiff, Tough, and Healable Ionic-Hydrogen Bond Cross-Linked Hydrogels and Their Uses as Building Blocks To Construct Complex Hydrogel Structures

Yongzhi Liang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Multidisciplinary Sciences

Adjacent cationic-aromatic sequences yield strong electrostatic adhesion of hydrogels in seawater

Hailong Fan et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Applied

Poly(lactic acid) based hydrogels: formation, characteristics and biomedical applications

Somayyah Abdul Munim et al.

JOURNAL OF POROUS MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Hierarchical Hydrogel Composite Interfaces with Robust Mechanical Properties for Biomedical Applications

Yuting Zhu et al.

ADVANCED MATERIALS (2019)

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Review Materials Science, Biomaterials

Advances in crosslinking strategies of biomedical hydrogels

Weikang Hu et al.

BIOMATERIALS SCIENCE (2019)

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Review Physics, Applied

From mechanical resilience to active material properties in biopolymer networks

Federica Burla et al.

NATURE REVIEWS PHYSICS (2019)

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Article Nanoscience & Nanotechnology

Semicrystalline Hydrophobically Associated Hydrogels with Integrated High Performances

Dandan Wei et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

Repeatable Photodynamic Therapy with Triggered Signaling Pathways of Fibroblast Cell Proliferation and Differentiation To Promote Bacteria-Accompanied Wound Healing

Congyang Mao et al.

ACS NANO (2018)

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Article Engineering, Biomedical

Injectable antibacterial conductive hydrogels with dual response to an electric field and pH for localized smart drug release

Jin Qu et al.

ACTA BIOMATERIALIA (2018)

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Article Engineering, Biomedical

Synthesis and characterization of arginine-NIPAAm hybrid hydrogel as wound dressing: In vitro and in vivo study

De-Qun Wu et al.

ACTA BIOMATERIALIA (2018)

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Article Chemistry, Multidisciplinary

Green Fabrication of Amphiphilic Quaternized beta-Chitin Derivatives with Excellent Biocompatibility and Antibacterial Activities for Wound Healing

Huan Xu et al.

ADVANCED MATERIALS (2018)

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Review Chemistry, Multidisciplinary

Supramolecular hydrogels for antimicrobial therapy

Benhui Hu et al.

CHEMICAL SOCIETY REVIEWS (2018)

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Review Chemistry, Multidisciplinary

Antibacterial Hydrogels

Shuqiang Li et al.

ADVANCED SCIENCE (2018)

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Article Engineering, Biomedical

Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing

Jin Qu et al.

BIOMATERIALS (2018)

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Article Chemistry, Applied

Cytocompatible chitosan based multi-network hydrogels with antimicrobial, cell anti-adhesive and mechanical properties

Wanjing Zou et al.

CARBOHYDRATE POLYMERS (2018)

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Article Chemistry, Multidisciplinary

Large Hydrogen-Bond Mismatch between TMAO and Urea Promotes Their Hydrophobic Association

Wen Jun Xie et al.

CHEM (2018)

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Article Materials Science, Multidisciplinary

Injectable polyphosphazene/gelatin hybrid hydrogel for biomedical applications

Zhaohui Huang et al.

MATERIALS & DESIGN (2018)

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Review Engineering, Biomedical

Chitosan based metallic nanocomposite scaffolds as antimicrobial wound dressings

Annapoorna Mohandas et al.

BIOACTIVE MATERIALS (2018)

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Article Engineering, Biomedical

Hydrogel Functionalized Janus Membrane for Skin Regeneration

Young-Hyeon An et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Article Multidisciplinary Sciences

An electric-eel-inspired soft power source from stacked hydrogels

Thomas B. H. Schroeder et al.

NATURE (2017)

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Review Multidisciplinary Sciences

A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings

Elbadawy A. Kamoun et al.

JOURNAL OF ADVANCED RESEARCH (2017)

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Article Nanoscience & Nanotechnology

pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing

Lingling Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Chemistry, Applied

Preparation and characterization of novel chitosan and β-cyclodextrin polymer sponges for wound dressing applications

Claudia Flores et al.

CARBOHYDRATE POLYMERS (2017)

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Article Chemistry, Multidisciplinary

Photo-Inspired Antibacterial Activity and Wound Healing Acceleration by Hydrogel Embedded with Ag/Ag@AgCl/ZnO Nanostructures

Congyang Mao et al.

ACS NANO (2017)

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Article Engineering, Biomedical

pH-responsive self-healing injectable hydrogel based on N-carboxyethyl chitosan for hepatocellular carcinoma therapy

Jin Qu et al.

ACTA BIOMATERIALIA (2017)

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Article Chemistry, Applied

Synthesis of cellulose-based double-network hydrogels demonstrating high strength, self-healing, and antibacterial properties

Yixi Wang et al.

CARBOHYDRATE POLYMERS (2017)

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Article Engineering, Biomedical

Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing

Xin Zhao et al.

BIOMATERIALS (2017)

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Review Chemistry, Multidisciplinary

Chemical Insights into Antibacterial N-Halamines

Alideertu Dong et al.

CHEMICAL REVIEWS (2017)

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Article Nanoscience & Nanotechnology

Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations

Yazhong Bu et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Nanoscience & Nanotechnology

Antibacterial and Anti-Inflammatory pH-Responsive Tannic Acid-Carboxylated Agarose Composite Hydrogels for Wound Healing

Neethu Ninan et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Engineering, Biomedical

Fluorinated methacrylamide chitosan hydrogels enhance collagen synthesis in wound healing through increased oxygen availability

Pritam S. Patil et al.

ACTA BIOMATERIALIA (2016)

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Article Chemistry, Applied

New antimicrobial chitosan derivatives for wound dressing applications

Oana Maria Dragostin et al.

CARBOHYDRATE POLYMERS (2016)

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Review Chemistry, Multidisciplinary

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

Xuewen Du et al.

CHEMICAL REVIEWS (2015)

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Review Chemistry, Multidisciplinary

The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial

C. Ghobril et al.

CHEMICAL SOCIETY REVIEWS (2015)

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Review Materials Science, Biomaterials

Fundamentals of double network hydrogels

Qiang Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2015)

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Review Chemistry, Multidisciplinary

Gelatin carriers for drug and cell delivery in tissue engineering

Marco Santoro et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Article Multidisciplinary Sciences

Nonswellable Hydrogel Without Mechanical Hysteresis

Hiroyuki Kamata et al.

SCIENCE (2014)

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Article Multidisciplinary Sciences

Injectable bioadhesive hydrogels with innate antibacterial properties

Michael C. Giano et al.

NATURE COMMUNICATIONS (2014)

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Review Dermatology

Electrical Stimulation of Wound Healing: A Review of Animal Experimental Evidence

Giti Torkaman

ADVANCES IN WOUND CARE (2014)

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Article Multidisciplinary Sciences

Highly stretchable and tough hydrogels

Jeong-Yun Sun et al.

NATURE (2012)

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Wound repair and regeneration

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NATURE (2008)

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