Cell membrane-coated nanomaterials for cancer therapy

With the development of nanotechnology, nanoparticles have emerged as a delivery carrier for tumor drug therapy, which can improve the therapeutic effect by increasing the stability and solubility and prolonging the half-life of drugs. However, nanoparticles are foreign substances for humans, are easily cleared by the immune system, are less targeted to tumors, and may even be toxic to the body. As a natural biological material, cell membranes have unique biological properties, such as good biocompatibility, strong targeting ability, the ability to evade immune surveillance, and high drug-carrying capacity. In this article, we review cell membrane-coated nanoparticles (CMNPs) and their applications to tumor therapy. First, we briefly describe CMNP characteristics and applications. Second, we present the characteristics and advantages of different cell membranes as well as nanoparticles, provide a brief description of the process of CMNPs, discuss the current status of their application to tumor therapy, summarize their shortcomings for use in cancer therapy, and propose future research directions. This review summarizes the research progress on CMNPs in cancer therapy in recent years and assesses remaining problems, providing scholars with new ideas for future research on CMNPs in tumor therapy.

Automated summary

With the development of nanotechnology, nanoparticles have been used as delivery carriers for tumor drug therapy, improving therapeutic effects. However, nanoparticles have limitations such as being foreign substances to the human body, easily cleared by the immune system, and having poor tumor targeting. Cell membrane-coated nanoparticles (CMNPs) have shown promise in addressing these limitations due to their unique biological properties. This review summarizes the characteristics, applications, and limitations of CMNPs in tumor therapy, and proposes future research directions.