Related references
Note: Only part of the references are listed.Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry
Wolfgang Schaefer et al.
MABS (2016)
Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency
Stylianos Bournazos et al.
CELL (2016)
Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity
Yaoxing Huang et al.
CELL (2016)
Development of purification processes for fully human bispecific antibodies based upon modification of protein A binding avidity
Andrew D. Tustian et al.
MABS (2016)
CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications
Anke Steinmetz et al.
MABS (2016)
RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis
Peter Brunker et al.
MOLECULAR CANCER THERAPEUTICS (2016)
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
Jonas Kloepper et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Preclinical pharmacokinetics, pharmacodynamics, and efficacy of RG7116: a novel humanized, glycoengineered anti-HER3 antibody
Georgina Meneses-Lorente et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2015)
Effect of Ang-2-VEGF-A Bispecific Antibody in Renal Cell Carcinoma
Hideharu Bessho et al.
CANCER INVESTIGATION (2015)
Bispecific antibodies
Roland E. Kontermann et al.
DRUG DISCOVERY TODAY (2015)
A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism
Zhi Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Development and validation of a novel SPR-based assay principle for bispecific molecules
C. Gassner et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2015)
Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization
M. Asokan et al.
JOURNAL OF VIROLOGY (2015)
Fab-based bispecific antibody formats with robust biophysical properties and biological activity
Xiufeng Wu et al.
MABS (2015)
Improving target cell specificity using a novel monovalent bispecific IgG design
Yariv Mazor et al.
MABS (2015)
Selective Delivery of PEGylated Compounds to Tumor Cells by Anti-PEG Hybrid Antibodies
Hsin-Yi Tung et al.
MOLECULAR CANCER THERAPEUTICS (2015)
Alternative molecular formats and therapeutic applications for bispecific antibodies
Christoph Spiess et al.
MOLECULAR IMMUNOLOGY (2015)
Identification of Anti-EGFR and Anti-ErbB3 Dual Variable Domains Immunoglobulin (DVD-Ig) Proteins with Unique Activities
Jinming Gu et al.
PLOS ONE (2015)
Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG
Nicolas Fischer et al.
NATURE COMMUNICATIONS (2015)
A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys
Eric J. Smith et al.
SCIENTIFIC REPORTS (2015)
Combating HER2-overexpressing breast cancer through induction of calreticulin exposure by Tras-Permut CrossMab
Fan Zhang et al.
ONCOIMMUNOLOGY (2015)
Four-in-One Antibodies Have Superior Cancer Inhibitory Activity against EGFR, HER2, HER3, and VEGF through Disruption of HER/MET Crosstalk
Shi Hu et al.
CANCER RESEARCH (2015)
Combined Inhibition of Tumor Necrosis Factor α and Interleukin-17 As a Therapeutic Opportunity in Rheumatoid Arthritis Development and Characterization of a Novel Bispecific Antibody
Jens A. A. Fischer et al.
ARTHRITIS & RHEUMATOLOGY (2015)
Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth
Kshitij Srivastava et al.
CANCER CELL (2014)
A Novel Glycoengineered Bispecific Antibody Format for Targeted Inhibition of Epidermal Growth Factor Receptor (EGFR) and Insulin-like Growth Factor Receptor Type I (IGF-1R) Demonstrating Unique Molecular Properties
Juergen M. Schanzer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Combating non- Hodgkin lymphoma by targeting both CD20 and HLA- DR through CD20-243 CrossMab
Lei Zhao et al.
MABS (2014)
Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface
Steven M. Lewis et al.
NATURE BIOTECHNOLOGY (2014)
Eradication of non-Hodgkin lymphoma through the induction of tumor-specific T-cell immunity by CD20-Flex BiFP
Lei Zhao et al.
BLOOD (2013)
RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation
Christian Mirschberger et al.
CANCER RESEARCH (2013)
Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy
Yvonne Kienast et al.
CLINICAL CANCER RESEARCH (2013)
Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines
Christoph Spiess et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Fc gamma receptors enable anticancer action of proapoptotic and immune-modulatory antibodies
Jeong M. Kim et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen
Ivan Correia et al.
MABS (2013)
Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig™) molecule
Clarissa G. Jakob et al.
MABS (2013)
Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies
Christoph Spiess et al.
NATURE BIOTECHNOLOGY (2013)
A novel bispecific EGFR/Met antibody blocks tumor-promoting phenotypic effects induced by resistance to EGFR inhibition and has potent antitumor activity
R. Castoldi et al.
ONCOGENE (2013)
Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity
Zenjiro Sampei et al.
PLOS ONE (2013)
A Novel Angiopoietin-2 Selective Fully Human Antibody with Potent Anti-Tumoral and Anti-Angiogenic Efficacy and Superior Side Effect Profile Compared to Pan-Angiopoietin-1/-2 Inhibitors
Markus Thomas et al.
PLOS ONE (2013)
Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain
Sebastian Fenn et al.
PLOS ONE (2013)
Aggregation and Chemical Modification of Monoclonal Antibodies under Upstream Processing Conditions
Stefan Dengl et al.
PHARMACEUTICAL RESEARCH (2013)
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
Aran F. Labrijn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair
Pavel Strop et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies
Christian Klein et al.
MABS (2012)
A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model
Takehisa Kitazawa et al.
NATURE MEDICINE (2012)
Molecular characterization of novel trispecific ErbB-cMet-IGF1R antibodies and their antigen-binding properties
R. Castoldi et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2012)
Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing
Silke Metz et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2012)
A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies
Gabriele Schaefer et al.
CANCER CELL (2011)
A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens
Gregory L. Moore et al.
MABS (2011)
A Human Neutralizing Antibody Specific to Ang-2 Inhibits Ocular Angiogenesis
Emma S. Rennel et al.
MICROCIRCULATION (2011)
Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
Wolfgang Schaefer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects APPLICATIONS TO BISPECIFIC MOLECULES AND MONOVALENT IgG
Kannan Gunasekaran et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies
Jonathan H. Davis et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2010)
Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site
Jenny Bostrom et al.
SCIENCE (2009)
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
Chengbin Wu et al.
NATURE BIOTECHNOLOGY (2007)
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
HS Cho et al.
NATURE (2003)
Potential role of the angiopoietin/Tie2 system in ischemia-induced retinal neovascularization
H Takagi et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2003)
Share Paper
