Journal
INTERNATIONAL JOURNAL OF BIOPRINTING
Volume 9, Issue 5, Pages 459-473Publisher
WHIOCE PUBL PTE LTD
DOI: 10.18063/ijb.773
Keywords
3D bioprinting; Nanoparticles; Silk fibroin; Antibacterial; Photodynamic therapy; Wound healing
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In this study, a composite photocrosslinked silk fibroin/gelatin hydrogel loaded with methylene blue/UiO-66(Ce) nanoparticles was fabricated. The hydrogel exhibited good biocompatibility, promoted cell migration and proliferation, and showed excellent antibacterial effect. It also accelerated the repair rate of full-thickness skin defects in mice.
Photo-crosslinked hydrogel (PH) is an outstanding candidate for three-dimensional (3D) printing as a wound dressing because of its high efficiency in crosslinking and injectability. In this study, methylene blue (MB)-loaded UiO-66(Ce) nanoparticles (NPs) were synthesized to prevent drug self-aggregation and achieve the photodynamic therapy (PDT) effect for efficient antibacterial action. Then, a composite photocrosslinked silk fibroin (SF)/gelatin hydrogel loaded with MB@UiO-66(Ce) NPs (MB@UiO-66(Ce)/PH) was fabricated. The printability and the improvement of the mechanical properties of the hydrogel by the NPs were clarified. The hydrogel exhibited good biocompatibility and promoted the migration and proliferation of fibroblasts. With the PDT effect of MB@UiO-66(Ce) NPs, the hydrogel showed an excellent antibacterial effect, which became more pronounced as the concentration increased. In vivo study showed that the MB@UiO-66(Ce)/PH could fill the defects without gaps and accelerate the repair rate of full-thickness skin defects in mice. The MB@UiO-66(Ce)/PH with antibacterial properties and tissue healing-promoting ability provides a new strategy involving 3D bioprinting for preparing wound dressings.
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