Journal
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
Volume 10, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/jcdd10060247
Keywords
adipokines; cytokines; heart failure with preserved ejection fraction; visceral adiposity
Categories
Ask authors/readers for more resources
In this study, researchers investigated the impact of qualitative and quantitative abnormalities of visceral fat on left ventricular diastolic dysfunction (LVDD). It was found that patients with LVDD had larger visceral fat area, which was correlated with BNP levels, LV mass index, mitral e' velocity, and E/e' ratio.
Background: Visceral fat produces inflammatory cytokines and may play a major role in heart failure with preserved ejection fraction (HFpEF). However, little data exist regarding how qualitative and quantitative abnormalities of visceral fat would contribute to left ventricular diastolic dysfunction (LVDD). Methods: We studied 77 participants who underwent open abdominal surgery for intra-abdominal tumors (LVDD, n = 44; controls without LVDD, n = 33). Visceral fat samples were obtained during the surgery, and mRNA levels of inflammatory cytokines were measured. Visceral and subcutaneous fat areas were measured using abdominal computed tomography. Results: Patients with significant LVDD had greater LV remodeling and worse LVDD than controls. While body weight, body mass index, and subcutaneous fat area were similar in patients with LVDD and controls, the visceral fat area was larger in patients with LVDD than in controls. The visceral fat area was correlated with BNP levels, LV mass index, mitral e & PRIME; velocity, and E/e & PRIME; ratio. There were no significant differences in the mRNA expressions of visceral adipose tissue cytokines (IL-2, -6, -8, and -1 & beta;, TNF & alpha;, CRP, TGF & beta;, IFN & gamma;, leptin, and adiponectin) between the groups. Conclusions: Our data may suggest the pathophysiological contribution of visceral adiposity to LVDD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available