Poly(2-acrylamido-2-methylpropane sulfonic acid)@butyl methacrylate latex anchored into polyethylene glycol diacrylate-based hydrogel composite for drug loading and controlled release studies

Hydrogels are applied in biomedical fields, especially in sustained drug release studies. However, improvements in their material properties are always needed to make them suitable for their potential biomedical use. Herein, a core-shell particles latex (CS) made of poly(2-acrylamido-2-methylpropane sulfonic acid)@butyl methacrylate anchored into polyethylene glycol diacrylate (PEGDA) matrix-based composite hydrogel (PEG-CS) was prepared through multiple steps free radical polymerization. The fabricated PEG-CS hydrogel was used for the loading and controlled release of ciprofloxacin as a model drug at various experimental conditions. An optimum drug concentration of 30 ppm at a loading efficiency of up to 660 mg/g for PEG-CS hydrogel was obtained after 8 h of adsorption, which was much higher than using only PEGDA-based hydrogel (control). The kinetic models and equilibrium isotherms of adsorption showed that the drug loading followed pseudo-second-order kinetics and the Langmuir adsorption isotherm, respectively. The drug demonstrated a sustained release at 37 & DEG;C and pH 7.4, at which 80% of the drug was released after 24 h. The Peppas equation gave n values of 0.50-0.60, indicating the drug release mechanism was governed by diffusion and erosion processes. The findings of this study show that the fabricated PEG-CS could be an efficient potential material for sustained drug release.

Automated summary

A core-shell particles latex composite hydrogel (PEG-CS) was prepared for controlled drug release of ciprofloxacin. Compared to the control PEGDA-based hydrogel, the PEG-CS hydrogel exhibited higher drug loading efficiency. The kinetic and equilibrium adsorption models suggested that the drug loading followed pseudo-second-order kinetics and the Langmuir adsorption isotherm, respectively. The findings indicate that the fabricated PEG-CS hydrogel could be an efficient material for sustained drug release.