☆ 4.6 Article

Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation

VETERINARY SCIENCES (2023)

Related references

Note: Only part of the references are listed.

Article Agriculture, Dairy & Animal Science

Study on the roles of melatonin in regulating dermal fibroblast growth in Liaoning cashmere goats by transcriptome sequencing

Mei Jin et al.

Summary: The study identified and verified genes related to the Downy growth of Liaoning cashmere goats, and found that melatonin treatments can significantly affect multiple signaling pathways, such as TNF and NOD-like receptor, thereby affecting the proliferation of skin fibroblasts.

ANIMAL BIOTECHNOLOGY (2022)

Add to Collection

Article Genetics & Heredity

Screening of microRNA and mRNA related to secondary hair follicle morphogenesis and development and functional analysis in cashmere goats

Fangzheng Shang et al.

Summary: This study investigated the expression profiles of miRNA and mRNA in cashmere goat fetal skin, and identified miRNAs and mRNAs related to the development of secondary hair follicles. Enrichment analysis revealed that some miRNA target genes were consistent with the screened mRNAs and enriched in Notch and TGF-beta signaling pathways. A regulatory network for the development of secondary hair follicles was constructed, and a targeted relationship between miR-30e-5p and DLL4 was confirmed. This study provides insights into the molecular mechanism of miRNA-mRNA in the development of hair follicles in cashmere goats.

FUNCTIONAL & INTEGRATIVE GENOMICS (2022)

Add to Collection

Article Agriculture, Dairy & Animal Science

Copy Number Variations Contribute to Intramuscular Fat Content Differences by Affecting the Expression of PELP1 Alternative Splices in Pigs

Xia Wei et al.

Summary: In this study, a genome-wide association study was conducted to investigate the relationship between copy number variations (CNVs) and intramuscular fat (IMF) in a pig F2 resource population. The results identified 19 CNVRs significantly associated with IMF. Further analysis indicated that CNV150, located on the 3' UTR end of the PELP1 gene, may affect the expression of alternative splices of PELP1 and ultimately impact the structure of PELP1 protein. These findings provide a novel mechanistic approach for improving meat quality in animals and potentially treating insulin resistance in humans.

ANIMALS (2022)

Add to Collection

Editorial Material Cell & Tissue Engineering

Reawakening GDNF's regenerative past in mice and humans

Andres Samos et al.

Summary: The ability of animals to regenerate lost tissue and body parts has important implications for life-saving. Understanding how this ability is regulated in different animal lineages helps us understand our own regeneration. Research has shown that the GDNF signaling pathway is conserved and plays a crucial role in regeneration in axolotls and regenerating Spiny mice.

REGENERATIVE THERAPY (2022)

Add to Collection

Article Agriculture, Dairy & Animal Science

Genome-wide association study revealed ABCD4 on SSC7 and GREB1L and MIB1 on SSC6 as crucial candidate genes for rib number in Beijing Black pigs

Naiqi Niu et al.

Summary: This study investigated the mechanism of rib number regulation in pigs and identified ABCD4 and VRTN on SSC7 as crucial candidate causal genes, as well as GREB1L and MIB1 on SSC6 as novel candidate genes, providing new insights into the genetic basis of rib number.

ANIMAL GENETICS (2022)

Add to Collection

Article Biology

Integrated Proteotranscriptomics Reveals Differences in Molecular Immunity between Min and Large White Pig Breeds

Liyu Yang et al.

Summary: In this study, transcriptomics and proteomics analysis were used to compare the immune differences between Chinese and foreign pig breeds, leading to the identification of critical genes and proteins involved in immune regulation. The results provide insights into breeding disease-resistant pigs.

BIOLOGY-BASEL (2022)

Add to Collection

Article Agriculture, Dairy & Animal Science

Identification of the Key Genes Associated with Different Hair Types in the Inner Mongolia Cashmere Goat

Gao Gong et al.

Summary: A weighted gene coexpression network analysis (WGCNA) was conducted on gene expression and phenotypic data of Inner Mongolia cashmere goats with long-hair and short-hair types to explore the molecular mechanisms and regulatory genes of different hair types. The results showed a strong correlation between one gene module and different hair types, with different expression trends observed between the two types. The GO functions of this module were mainly concentrated in cellular components, while the KEGG pathways were enriched in arginine and proline metabolism and the MAPK signaling pathway. Nine candidate genes were identified as significantly different between the two hair types, with most of them showing a positive correlation with hair length. These candidate genes are believed to regulate the different hair types of cashmere goats and provide molecular markers for hair growth.

ANIMALS (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Construction of transcriptome atlas of white yak hair follicle during anagen and catagen using single-cell RNA sequencing

Qingbo Zheng et al.

Summary: By conducting single-cell RNA sequencing and analysis, this study revealed the gene expression characteristics and differentiation trajectories of different cell types in yak hair follicles during anagen and catagen, providing important insights for understanding the hair follicle cycle and promoting the development and utilization of yak villi.

BMC GENOMICS (2022)

Add to Collection

Article Veterinary Sciences

Transcriptome Analysis Reveals Genes Contributed to Min Pig Villi Hair Follicle in Different Seasons

Ming Tian et al.

Summary: This research describes the phenotype of Min pig dermal villi and sequenced the mRNA transcriptome of Min pig hair follicles. The results showed that the hair growth in Min pigs is regulated by an interaction network composed of eight core genes. This study contributes to the current understanding of the growth mechanism of different types of hair.

VETERINARY SCIENCES (2022)

Add to Collection

Article Biology

Whole-Genome Resequencing Points to Candidate DNA Loci Affecting Body Temperature under Cold Stress in Siberian Cattle Populations

Alexander Igoshin et al.

Summary: Using whole-genome resequencing of animals showing contrasting phenotypes on temperature maintenance under acute cold stress and existing SNP functional annotations, this study identified chromosomal regions and candidate SNPs controlling body temperature in Siberian cattle populations. The research highlighted multiple candidate genes related to thermal adaptations in cattle and provided insights for cattle breeding strategies in harsh climates, including the Russian Federation.

LIFE-BASEL (2021)

Add to Collection

Article Multidisciplinary Sciences

Identification of potential key genes and pathways associated with the Pashmina fiber initiation using RNA-Seq and integrated bioinformatics analysis

Basharat Bhat et al.

Summary: The Pashmina goat, known for its valuable Pashmina fiber, has a double coat fleece adapted to harsh cold conditions. Transcriptome analysis revealed key genes and signaling pathways regulating follicle growth phases, with differential gene expression suggesting control by pathways like Wnt, NF-Kappa, and JAK-STAT. Genes from Integrin family and Cell adhesion molecules were highly expressed during the active phase, along with potential involvement of transcription factors like RUNX3 and GATA family in fiber quality maintenance.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Oncology

Increased expression of PSME2 is associated with clear cell renal cell carcinoma invasion by regulating BNIP3-mediated autophagy

Xiaoyun Wang et al.

Summary: Previous studies have indicated a potential role of PSME2 in certain types of cancer, but its involvement in ccRCC was previously unknown. This study found that PSME2 is associated with the invasive abilities of ccRCC cell lines by inhibiting BNIP3-mediated autophagy, suggesting that PSME2 could serve as a prognostic factor and a promising therapeutic target in ccRCC.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

Add to Collection

Review Medical Laboratory Technology

NUDT15: A bench to bedside success story

Ann M. Moyer

Summary: NUDT15 has been identified as an additional component in the thiopurine metabolism pathway, catalyzing the dephosphorylation of active metabolites. Genetic variations leading to decreased NUDT15 activity have been recognized as an additional contributor to thiopurine toxicity, particularly in Asian and Latino populations. Clinical genetic testing is now available for a subset of NUDT15 variants, representing a fast translation from bench to bedside.

CLINICAL BIOCHEMISTRY (2021)

Add to Collection

Review Physiology

Introduction to DOK2 and its Potential Role in Cancer

Pei Sun et al.

Summary: This review focuses on the role of DOK2 in various types of tumors in the lungs, intestines, liver, and breast, as well as the potential mechanisms of action via the Ras/MPAK/ERK or PI3K/AKT/mTOR signaling pathways.

PHYSIOLOGICAL RESEARCH (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Genomic scans for selection signatures revealed candidate genes for adaptation and production traits in a variety of cattle breeds

K. A. Saravanan et al.

Summary: Domestication and selection in livestock lead to determinative genetic variability, creating unique genetic signatures. Analysis of BovineSNP50 chip data identified candidate genes related to production traits and adaptation of indigenous breeds, with further studies recommended for validation.

GENOMICS (2021)

Add to Collection

Article Ecology

Ontogenetic niche shifts as a driver of seasonal migration

Wimke Fokkema et al.

OECOLOGIA (2020)

Add to Collection

Article Agriculture, Dairy & Animal Science

Whole genome variants across 57 pig breeds enable comprehensive identification of genetic signatures that underlie breed features

Jingya Xu et al.

JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY (2020)

Add to Collection

Article Chemistry, Medicinal

Association between the c.415C > T, c.52G > A, and 36_37insGGAGTC polymorphisms of NUDT 15 and thiopurine-induced leukopenia, thiopurine intolerance, and severe hair loss: an updated meta-analysis

Ruili Wang et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Building a livestock genetic and genomic information knowledgebase through integrative developments of Animal QTLdb and CorrDB

Zhi-Liang Hu et al.

NUCLEIC ACIDS RESEARCH (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Transcriptomics Analysis on Excellent Meat Quality Traits of Skeletal Muscles of the Chinese Indigenous Min Pig Compared with the Large White Breed

Yingzi Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Article Agriculture, Dairy & Animal Science

Expression of fox-related genes in the skin follicles of Inner Mongolia cashmere goat

Wenjing Han et al.

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling

Jenny Sandmark et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Add to Collection

Article Dermatology

Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2

Johannes Fischer et al.

EXPERIMENTAL DERMATOLOGY (2017)

Add to Collection

Article Oncology

Differential expression pattern of protein markers for predicting chemosensitivity of dexamethasone-based chemotherapy of B cell acute lymphoblastic leukemia

Nasrin Dehghan-Nayeri et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2017)

Add to Collection

Review Neurosciences

Lateral hypothalamic circuits for feeding and reward

Garret D. Stuber et al.

NATURE NEUROSCIENCE (2016)

Add to Collection

Article Dermatology

Progressive hyperpigmentation in a Taiwanese child due to an inborn error of vitamin B12 metabolism (cblJ)

T. Takeichi et al.

BRITISH JOURNAL OF DERMATOLOGY (2015)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

Latent transforming growth factor- binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization

M-S Chiang et al.

ORAL DISEASES (2015)

Add to Collection

Article Biochemistry & Molecular Biology

ATF1 Modulates the Heat Shock Response by Regulating the Stress-Inducible Heat Shock Factor 1 Transcription Complex

Ryosuke Takii et al.

MOLECULAR AND CELLULAR BIOLOGY (2015)

Add to Collection

Article Multidisciplinary Sciences

Genetic Diversity, Linkage Disequilibrium and Selection Signatures in Chinese and Western Pigs Revealed by Genome-Wide SNP Markers

Huashui Ai et al.

PLOS ONE (2013)

Add to Collection

Review Multidisciplinary Sciences

Finding the missing heritability of complex diseases

Teri A. Manolio et al.

NATURE (2009)

Add to Collection

Review Biochemistry & Molecular Biology

Electrophysiological effects of MCH on neurons in the hypothalamus

Xiao-Bing Gao

PEPTIDES (2009)

Add to Collection

Article Dermatology

Expression patterns of the glial cell line-derived neurotrophic factor, neurturin, their cognate receptors GFRα-1, GFRα-2, and a common signal transduction element c-Ret in the human skin hair follicles

Mohamed A. Adly et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2008)

Add to Collection

Article Multidisciplinary Sciences

Identification and characterization of a melanin-concentrating hormone receptor

SZ An et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Add to Collection

Article Multidisciplinary Sciences

Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R

AW Sailer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.