4.7 Review

Advances in Hydrogel Adhesives for Gastrointestinal Wound Closure and Repair

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Robust hydrogel adhesives for emergency rescue and gastric perforation repair

Jing Yu et al.

Summary: In this study, a potent hydrogel adhesive was developed by free radical polymerization. The hydrogel exhibited strong adhesive properties and hemostasis effect, making it a promising candidate for emergency rescue and tissue repair applications.

BIOACTIVE MATERIALS (2023)

Article Chemistry, Multidisciplinary

Endoscopy Deliverable and Mushroom-Cap- Inspired Hyperboloid-Shaped Drug-Laden Bioadhesive Hydrogel for Stomach Perforation

Shuang Liu et al.

Summary: This study reports a self-expandable gel device for blocking gastric perforation. The device, with a nanosilica coating and drug-loading capabilities, can enhance adhesive strength, regulate intragastric pH, and promote wound healing. The experiments demonstrated the excellent performance of the gel device in animal models.

ACS NANO (2023)

Review Engineering, Chemical

Interpenetrating polymer network hydrogels as bioactive scaffolds for tissue engineering

Cody O. Crosby et al.

Summary: This article proposes the development of interpenetrating polymer network (IPN) hydrogels as biomaterial scaffolds in tissue engineering, aiming to address the current challenges in clinical translation. The authors review recent advancements in improving the mechanical strength, substrate-scale stiffness, electrical conductivity, and degradation of IPN hydrogels and highlight their incorporation into state-of-the-art tissue engineering technologies. These materials have critical importance in engineering functional tissues for transplantation, disease modeling, and drug screening.

REVIEWS IN CHEMICAL ENGINEERING (2022)

Article Chemistry, Multidisciplinary

Adhesive Hemostatic Hydrogel with Ultrafast Gelation Arrests Acute Upper Gastrointestinal Hemorrhage in Pigs

Xianfeng Xia et al.

Summary: A novel hemostatic hybrid hydrogel comprised of hyaluronic acid and polyethylene glycol stabilized by thiourea-catechol coupling and disulfide bonds is reported for endoscopic hemostasis in upper GI hemorrhage. The hybrid hydrogels exhibit enhanced mechanical properties and good blood clotting ability, showing promising results in both rat and pig models. The sustained hemostatic function of the hybrid hydrogels make them a potential candidate for clinical applications in endoscopic hemostasis.

ADVANCED FUNCTIONAL MATERIALS (2022)

Article Cell Biology

An off-the-shelf bioadhesive patch for sutureless repair of gastrointestinal defects

Jingjing Wu et al.

Summary: This study introduces an off-the-shelf bioadhesive gastrointestinal (GI) patch that can rapidly and robustly repair GI defects without the need for sutures. The patch has been shown to be biocompatible and degradable, and has demonstrated successful sealing and healing of GI defects in animal models.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Article Materials Science, Multidisciplinary

Dual-network hydrogel based on ionic nano-reservoir for gastric perforation sealing

Yuehui Yuan et al.

Summary: Researchers have proposed an ionic nano-reservoir (INR)-based dual-network hydrogel for the treatment of gastric perforation, which has excellent adhesion and mechanical properties, and can promote tissue repair while blocking the perforation.

SCIENCE CHINA-MATERIALS (2022)

Article Engineering, Biomedical

An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation

Jing Chen et al.

Summary: Adhesive hydrogels have been proposed as a potential treatment for gastric perforation, and this study presents an adhesive and resilient hydrogel that effectively seals and promotes regeneration of gastric mucosa.

BIOACTIVE MATERIALS (2022)

Review Polymer Science

Hydrogel adhesives for generalized wound treatment: Design and applications

Meng Li et al.

Summary: This article reviews the research progress of hydrogel adhesives in wound treatment and emphasizes the importance of their design principles and unique requirements in generalized wounds.

JOURNAL OF POLYMER SCIENCE (2022)

Article Chemistry, Multidisciplinary

Bio-Inspired Self-Hydrophobized Sericin Adhesive with Tough Underwater Adhesion Enables Wound Healing and Fluid Leakage Sealing

Huan Liu et al.

Summary: Inspired by the strong underwater adhesion of natural creatures, scientists have developed a self-hydrophobized adhesive with robust adhesive properties and various advantages, such as promoting wound healing and hemostasis.

ADVANCED FUNCTIONAL MATERIALS (2022)

Article Chemistry, Multidisciplinary

Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing

Xingmei Chen et al.

Summary: An acid-tolerant hydrogel (ATGel) bioadhesive has been developed, which can achieve instant, atraumatic, fluid-tight, and sutureless sealing of gastric perforation, addressing the limitations of traditional methods. In vivo investigation on a rat model confirms the acid-tolerant bioadhesion of ATGel and identifies the mechanisms for accelerated gastric perforation repair.

ADVANCED FUNCTIONAL MATERIALS (2022)

Review Gastroenterology & Hepatology

Current status in endoscopic management of upper gastrointestinal perforations, leaks and fistulas

Shannon Melissa Chan et al.

Summary: Recent advancements in endoscopic closure techniques have transformed the treatment of gastrointestinal perforations, leaks, and fistulas. The choice of treatment strategy depends on various factors such as the size and location of the defect, degree of contamination, and patient condition. Different endoscopic techniques have distinct indications and limitations, often requiring a combination of methods for effective management.

DIGESTIVE ENDOSCOPY (2022)

Review Biotechnology & Applied Microbiology

Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing

Jianghui Qin et al.

Summary: Wound healing is a complex biological process with bioengineered scaffolds playing a key role in regenerative therapy. Although advancements have been made, challenges remain in achieving ideal treatment for deep cutaneous injuries. Designing innovative scaffolds, precursor development, and therapeutic interventions hold promise for future wound healing strategies.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Article Multidisciplinary Sciences

Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment

Alexandre H. C. Anthis et al.

Summary: The study presents an intelligent suture support sealant patch capable of containing and detecting gastrointestinal surgery leaks early. By using pH and/or enzyme-responsive triggerable sensing elements, the breaches of sutures in intestinal and gastric leak scenarios can be reliably detected within 3 hours and 15 minutes, respectively.

NATURE COMMUNICATIONS (2022)

Article Surgery

Design and fabrication of modified bi-layer poly vinyl alcohol adhesive sealant film for preventing gastrointestinal leakage

Erfan Dorkhani et al.

Summary: This study focused on evaluating the effectiveness of a sealant structure based on poly (vinyl alcohol) film patterned with gelatin particles for the prevention of anastomosis leakage. The results showed that the film with an oriented pattern had better adhesive and mechanical properties, and promoted the expression of anti-inflammatory cytokines and collagen deposition. This novel sealant can be considered as a new method for preventing anastomosis leakage.

FRONTIERS IN SURGERY (2022)

Editorial Material Engineering, Biomedical

Sutureless gastrointestinal anastomoses

Alexandre H. C. Anthis et al.

Summary: An adhesive hydrogel patch made from off-the-shelf materials has been shown to seal and aid the healing of gastrointestinal-tissue defects in live rats and pigs, without the need for sutures.

NATURE BIOMEDICAL ENGINEERING (2022)

Article Engineering, Biomedical

Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing

Xiaowei Liu et al.

Summary: This study presents a half-dry adhesive composed of silk fibroin and poly(acrylic acid) covalent network. The adhesive exhibits rapid liquid adsorption and repulsion process, as well as excellent flexibility and toughness on a wet tissue. The adhesive shows remarkable hemostatic effects and effective closure of various incisions in vitro and in vivo.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Nanoscience & Nanotechnology

Strong Biopolymer-Based Nanocomposite Hydrogel Adhesives with Removability and Reusability for Damaged Tissue Closure and Healing

Yu Tian et al.

Summary: In this study, an injectable biopolymer hydrogel bioadhesive incorporated with mesoporous bioactive glass nanoparticles (MBGN) was reported. The bioadhesive exhibits strong adhesion, removability and reusability at physiological temperatures, as well as excellent biocompatibility and therapeutic effects. This novel design of bioadhesive holds great potential for various medical applications.

ACS APPLIED MATERIALS & INTERFACES (2022)

Review Gastroenterology & Hepatology

Endoscopic Solutions for Colorectal Anastomotic Leaks

Andrea Martina Guida et al.

Summary: This article presents a comprehensive summary of endoscopic procedures for the treatment of fistula following rectal cancer surgery. Transrectal vacuum-assisted closure, Over-The-Scope clipping system, and OverStitch suturing system are the most commonly used endoscopic solutions. Early detection of anastomotic leak can increase the success rate of endoscopic techniques and reduce healing time and hospital stay.

TECHNIQUES AND INNOVATIONS IN GASTROINTESTINAL ENDOSCOPY (2022)

Article Materials Science, Biomaterials

Ascidian-inspired aciduric hydrogels with high stretchability and adhesiveness promote gastric hemostasis and wound healing

Wenliang Xue et al.

Summary: The aciduric bionic hydrogel adhesives, inspired by the high adhesiveness of the ascidian secretory protein, show great potential in treating gastric hemorrhages and promoting wound healing, due to their enhanced wet tissue adhesion, higher stretchability, and aciduric stability.

BIOMATERIALS SCIENCE (2022)

Review Gastroenterology & Hepatology

Current endoscopic closure techniques for the management of gastrointestinal perforations

Dominic Staudenmann et al.

Summary: Acute gastrointestinal perforations can occur spontaneously or iatrogenically. Timely diagnosis and endoscopic closure are essential for acute iatrogenic perforations to prevent complications and mortality.

THERAPEUTIC ADVANCES IN GASTROINTESTINAL ENDOSCOPY (2022)

Review Gastroenterology & Hepatology

Role of minimally invasive techniques in gastrointestinal surgery: Current status and future perspectives

Shan-Ping Ye et al.

Summary: Minimally invasive surgery has become a common method for treating gastrointestinal cancer, with challenges such as operating in narrow spaces and questioning oncologic outcomes. Most studies suggest that minimally invasive techniques are safe and feasible in gastrointestinal cancer surgery.

WORLD JOURNAL OF GASTROINTESTINAL SURGERY (2021)

Article Materials Science, Biomaterials

EGFR-conjugated hydrogel accelerates wound healing on ulcer-induced burn wounds by targeting collagen and inflammatory cells using photoimmunomodulatory inhibition

Karuppusamy Shanmugapriya et al.

Summary: In this study, an EGFR-conjugated hydrogel was fabricated to promote wound healing in cold restraint-induced gastric ulceration on burn wounds, demonstrating good biocompatibility and enhanced healing ability. In vivo experiments showed that EGFR-H had stronger ulcer healing ability compared to hydrogel alone and controls.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Pharmacology & Pharmacy

Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

Vicky Barmpatsalou et al.

Summary: The study characterized the gastrointestinal mucus in pigs to understand its impact on drug absorption in different regions of the gastrointestinal tract. This research provided valuable information on the physiological properties, composition, and structure of porcine gastrointestinal mucus, allowing for comparisons and enhancing the understanding of its role in drug absorption. Additionally, it can contribute to the evaluation of the pig model in drug development as a preclinical species.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

Review Biotechnology & Applied Microbiology

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Hamed Nosrati et al.

Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Chemistry, Multidisciplinary

Chemically Stable, Strongly Adhesive Sealant Patch for Intestinal Anastomotic Leakage Prevention

Alexandre H. C. Anthis et al.

Summary: Intestinal anastomotic leaking is a serious complication of abdominal surgery, with current surgical sealants often inadequate. A chemically resistive, leak-tight hydrogel patch shows promise in effectively sealing leaks and surpassing commercial sealants.

ADVANCED FUNCTIONAL MATERIALS (2021)

Review Chemistry, Multidisciplinary

Polymeric Tissue Adhesives

Sungmin Nam et al.

Summary: Polymeric tissue adhesives are versatile materials widely used in wound management, offering relative ease of use and rapid application while also acting as hemostats. Despite facing challenges, advancements in tissue adhesives may provide new possibilities for wound care.

CHEMICAL REVIEWS (2021)

Review Biochemistry & Molecular Biology

Antimicrobial Properties of Chitosan and Chitosan Derivatives in the Treatment of Enteric Infections

Dazhong Yan et al.

Summary: Chitosan, a natural antimicrobial polymer, has potential as an alternative for antibiotics in therapy and disinfection due to its ability to kill microbes by neutralizing their negative charges on the surface. Chemically modified chitosan derivatives have better water solubility and antimicrobial properties, offering promise for improvement in the treatment of enteric infections.

MOLECULES (2021)

Article Gastroenterology & Hepatology

Therapeutic Potential of a Self-Assembling Peptide Hydrogel to Treat Colonic Injuries Associated with Inflammatory Bowel Disease

Toshihiro Araki et al.

Summary: The study found that self-assembling peptide hydrogel can effectively reduce the length and area of colonic ulcers, decrease colonic weight and histological score, as well as regulate the expression of inflammatory factors and promote wound healing-related factors.

JOURNAL OF CROHNS & COLITIS (2021)

Article Nanoscience & Nanotechnology

Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

Jiahui He et al.

Summary: A series of injectable pH-responsive self-healing adhesive hydrogels have been developed for treating gastric bleeding and wound healing after endoscopic treatment. These hydrogels show great potential as endoscopic sprayable bioadhesive materials, with good hemostatic properties and enhanced wound healing effects in animal models.

NANO-MICRO LETTERS (2021)

Article Engineering, Biomedical

Marine-inspired molecular mimicry generates a drug-free, but immunogenic hydrogel adhesive protecting surgical anastomosis

Jinjian Huang et al.

Summary: This study demonstrates a novel strategy for generating an adhesive by mimicking marine animals and shows that the Da-g-Xan adhesive can significantly improve protective effects on colonic anastomosis in a rat model. The structure of the Da-g-Xan hydrogel is maintained by dynamic intermolecular hydrogen bonds to allow quick release of dopamine-conjugated xanthan gum, which can regulate inflammatory status and induce type 2 macrophage polarization. The adhesive creates an appropriate microenvironment for tissue healing by promoting chemokine and growth factor secretion from M2 macrophages, enhancing fibroblast migration and proliferation, collagen synthesis, and epithelial vascularization.

BIOACTIVE MATERIALS (2021)

Article Engineering, Biomedical

Polycaprolactone-gelatin membrane as a sealant biomaterial efficiently prevents postoperative anastomotic leakage with promoting tissue repair

Gyeongjin Joo et al.

Summary: The fibrous membrane sealing patch developed using a combination of PCL and gelatin showed promising results in preventing post-surgical leakage, with higher gelatin content leading to better outcomes in terms of fiber diameter and hydrophilicity. The P1G4 membrane, with a ratio of PCL to gelatin at 1:4, exhibited optimal performance in an in vivo study, demonstrating its potential as a biomaterial for tissue repair to prevent leakage after surgery.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2021)

Article Materials Science, Biomaterials

Robust closure of post-endoscopic submucosal dissection perforation by microparticle-based wound dressing

Shima Ito et al.

Summary: This study reported on a microparticle-based wound dressing with hydrophobically-modified gelatin that can close perforations after Endoscopic submucosal dissection (ESD), improving burst strength and potentially preventing delayed perforations.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Review Biochemistry & Molecular Biology

Electrospun Medicated Nanofibers for Wound Healing: Review

Xinkuan Liu et al.

Summary: With the increasing demand for wound care and treatment worldwide, traditional dressings are unable to meet market needs. Electrospinning technology has become a focus of research, with electrospun nanofiber membranes possessing a unique structure and biological function similar to ECM, making them advanced dressings. Electrospun dressings have the potential to encapsulate and deliver active substances that promote wound healing.

MEMBRANES (2021)

Review Gastroenterology & Hepatology

Prevention of late complications with coverage agents in endoscopic resection of colorectal lesions: Current landscape in gastrointestinal endoscopy

Vicente Lorenzo-Zuniga et al.

Summary: The use of coverage agents to protect mucosal defects post-endoscopic resection can effectively prevent delayed bleeding and delayed perforation in large non-pedunculated colorectal lesions. Shielding the eschar after endoscopic resection provides protection to reduce complications.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Review Medicine, General & Internal

Minimally invasive gastrointestinal surgery: From past to the future

Reno Rudiman

Summary: Improvement in the science and art of surgery began over 150 years ago, but in the 21st century, there has been a paradigm shift towards minimally invasive surgery (MIS) which has replaced open surgery with improved survival rates, fewer complications, and faster recoveries. Further research in MIS is ongoing to achieve truly noninvasive surgery.

ANNALS OF MEDICINE AND SURGERY (2021)

Review Materials Science, Biomaterials

Engineering Hydrogel Adhesion for Biomedical Applications via Chemical Design of the Junction

Giovanni Bovone et al.

Summary: Hydrogel adhesion relies on engineering the contact surface at soft and hydrated interfaces, forming adhesion junctions through chemical or physical interactions. Designing the binding chemistries or adhesion junctions, whether covalent, dynamic covalent, supramolecular, or physical, is linked to the emergent adhesive properties of soft and hydrated interfaces, useful for bonding in biomedical applications. Main focus is on engineering hydrogel adhesion through molecular design of the junctions to tailor the adhesion strength, reversibility, stability, and response to environmental stimuli.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

Article Chemistry, Multidisciplinary

Injectable Self-Healing Hydrogel via Biological Environment-Adaptive Supramolecular Assembly for Gastric Perforation Healing

Wenda Wang et al.

Summary: An injectable self-healing hydrogel based on gastric environment-adaptive supramolecular assembly has been developed for gastric perforation healing. The hydrogel dressing possesses sensitive thermo-responsibility, injectability, antibiofouling property, simplifying surgical procedures, reducing postoperative complications, and enhancing the healing process. This work provides valuable insights for the development of biological environment-adaptive functional materials for biomedical applications.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Bio-Multifunctional Hydrogel Patches for Repairing Full-Thickness Abdominal Wall Defect

Xiangyi Yin et al.

Summary: The study developed a novel bio-multifunctional hydrogel patch for accelerating full-thickness abdominal wall defect repair, showing excellent self-healing and mechanical properties, antibacterial ability, and promotion of cell proliferation.

ADVANCED FUNCTIONAL MATERIALS (2021)

Review Chemistry, Multidisciplinary

Bioinspired Underwater Adhesives

Hailong Fan et al.

Summary: Underwater adhesives are in high demand due to their specific challenges in development and performance on wet or submerged surfaces. Current strategies include different types of underwater adhesives and their development and performance based on various mechanisms and strategies. Possible research directions and prospects for underwater adhesives are also discussed.

ADVANCED MATERIALS (2021)

Article Multidisciplinary Sciences

The feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study

Yuko Miura et al.

Summary: The study developed a novel injectable hydrogel for protecting post-endoscopic ulcers which showed a significantly lower perforation rate and smaller ulcer diameter in rat models. Histopathological analysis revealed higher inflammatory cell count in the control group.

SCIENTIFIC REPORTS (2021)

Article Chemistry, Analytical

Post-Operative Monitoring of Intestinal Tissue Oxygenation Using an Implantable Microfabricated Oxygen Sensor

Jamie R. K. Marland et al.

Summary: Anastomotic leakage (AL) is a common and dangerous post-operative complication following intestinal resection, often associated with ischemia in the tissue surrounding the anastomosis. A miniature implantable electrochemical oxygen sensor has been developed to continuously monitor tissue oxygenation, providing early identification of AL risk and accurate detection of intestinal ischemia. The sensor demonstrated sensitivity and accuracy in detecting tissue oxygenation changes and proved suitable for continuous monitoring of anastomosis oxygenation over an extended period.

MICROMACHINES (2021)

Article Materials Science, Biomaterials

Temporary In Situ Hydrogel Dressings for Colon Polypectomies

Katherine Cook et al.

Summary: This study reported the design, synthesis, and ex vivo evaluation of in situ polymerized hydrogels as colon wound dressings post polypectomy, with varied properties such as moduli, dissolution times, swelling, and adhesion to colon tissue. The hydrogels showed minimal cytotoxicity, prevented bacterial migration, exhibited rapid gelation, and have potential for application in colon endoscopy.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

Article Multidisciplinary Sciences

Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations

Xin Peng et al.

Summary: The PEI/PAA powder demonstrates strong wet adhesion by forming a physically cross-linked hydrogel on wet tissues, making it suitable for various biomedical applications.

SCIENCE ADVANCES (2021)

Review Biotechnology & Applied Microbiology

Clinical Use of the Self-Assembling Peptide RADA16: A Review of Current and Future Trends in Biomedicine

Sharanya Sankar et al.

Summary: RADA16 is a synthetic peptide that self-assembles into nanofiber hydrogels in an acidic environment and quickly forms a stable transparent hydrogel matrix in physiological pH. It is used as a hemostatic agent in surgical procedures to control bleeding and prevent rebleeding, with potential applications in wound healing and adhesion reduction. The unique properties of RADA16 make it an ideal candidate for tissue regeneration and controlled drug delivery in the future.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Article Medicine, Research & Experimental

Double-layered Nanofibrous Patch for Prevention of Anastomotic Leakage and Peritoneal Adhesions, Experimental Study

Jachym Rosendorf et al.

Summary: The study found that double-layered nanofibrous materials may help prevent anastomotic leakage but could delay the healing process. The wound healing was inferior in the experimental groups, however, no anastomotic leakage was observed, and the extent of adhesions was larger in the experimental groups.

IN VIVO (2021)

Review Engineering, Biomedical

Recent advances on polymeric hydrogels as wound dressings

Zheng Pan et al.

Summary: Hydrogels are attracting intensive attention for their high porosity, good biocompatibility, and beneficial properties for wound healing. Traditional hemostasis methods have limitations, while hydrogel dressings offer more advantages. Future research and development should focus on overcoming the challenges of hydrogel dressings and improving their performance and applications.

APL BIOENGINEERING (2021)

Review Engineering, Biomedical

Peritoneal adhesions: Occurrence, prevention and experimental models

Jingyi Tang et al.

ACTA BIOMATERIALIA (2020)

Article Chemistry, Multidisciplinary

A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti-Postoperative Adhesion

Chunyan Cui et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Review Biochemistry & Molecular Biology

Recent Progress of Highly Adhesive Hydrogels as Wound Dressings

Liwei Zhang et al.

BIOMACROMOLECULES (2020)

Review Polymer Science

Scaffolds for Wound Healing Applications

Irina Negut et al.

POLYMERS (2020)

Review Medicine, General & Internal

Review of Colonic Anastomotic Leakage and Prevention Methods

Alex H. Fang et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Tissue-sealing and anti-adhesion properties of an in situ hydrogel of hydrophobically-modified Alaska pollock-derived gelatin

Yosuke Mizuno et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Multidisciplinary Sciences

Dry double-sided tape for adhesion of wet tissues and devices

Hyunwoo Yuk et al.

NATURE (2019)

Article Materials Science, Biomaterials

A shear-thinning adhesive hydrogel reinforced by photo-initiated crosslinking as a fit-to-shape tissue sealant

Shaoquan Bian et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

Review Gastroenterology & Hepatology

Role of hemostatic powders in the management of lower gastrointestinal bleeding: A review

Fadi H. Mourad et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Pediatrics

Solution blow spun polymer: A novel preclinical surgical sealant for bowel anastomoses

Nora G. Kern et al.

JOURNAL OF PEDIATRIC SURGERY (2017)

Article Materials Science, Biomaterials

Design and development of a hybrid bioartificial water-induced shape memory polymeric material as an integral component for the anastomosis of human hollow organs

Siriana Paonessa et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

Editorial Material Gastroenterology & Hepatology

Endoscopic shielding technique, a new method in therapeutic endoscopy

Ignacio Bon et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Review Nanoscience & Nanotechnology

Polymeric hydrogels for post-operative adhesion prevention: A review

Kun Shi et al.

MATERIALS EXPRESS (2017)

Article Nanoscience & Nanotechnology

Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations

Yazhong Bu et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Article Gastroenterology & Hepatology

International consensus statement regarding the use of animal models for research on anastomoses in the lower gastrointestinal tract

Joanna W. A. M. Bosmans et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2016)

Article Cell & Tissue Engineering

Enhanced intestinal anastomotic healing with gelatin hydrogel incorporating basic fibroblast growth factor

Kenjiro Hirai et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2016)

Review Chemistry, Multidisciplinary

The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial

C. Ghobril et al.

CHEMICAL SOCIETY REVIEWS (2015)

Review Polymer Science

Biomedical applications of hydrogels: A review of patents and commercial products

Enrica Calo et al.

EUROPEAN POLYMER JOURNAL (2015)

Review Gastroenterology & Hepatology

Management of low colorectal anastomotic leak: Preserving the anastomosis

Jennifer Blumetti et al.

WORLD JOURNAL OF GASTROINTESTINAL SURGERY (2015)

Article Multidisciplinary Sciences

On the strength of β-sheet crystallites of Bombyx mori silk fibroin

Yuan Cheng et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2014)

Article Chemistry, Multidisciplinary

Advances in interpenetrating polymer network hydrogels and their applications

Ecaterina Stela Dragan

PURE AND APPLIED CHEMISTRY (2014)

Review Surgery

Tissue adhesives in gastrointestinal anastomosis: a systematic review

Konstantinos A. Vakalopoulos et al.

JOURNAL OF SURGICAL RESEARCH (2013)

Review Gastroenterology & Hepatology

The gastrointestinal mucus system in health and disease

Malin E. V. Johansson et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2013)

Article Cardiac & Cardiovascular Systems

Acidic and basic fibroblast growth factors involved in cardiac angiogenesis following infarction

Tieqiang Zhao et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2011)

Article Gastroenterology & Hepatology

Imaging Update: Acute Colonic Diverticulitis

Kristen DeStigter et al.

Clinics in Colon and Rectal Surgery (2009)

Article Surgery

Effect of povidone-iodine liposome hydrogel on colonic anastomosis

S Ustek et al.

EUROPEAN SURGICAL RESEARCH (2005)