Same, same or different? Commonalities and differences between spondyloarthritis and its subsets of axial and peripheral spondyloarthritis with psoriatic arthritis and its diverse phenotypes

Letter Rheumatology

Response to: Correspondence on 'No efficacy of anti-IL-23 therapy for axial spondyloarthritis in randomised controlled trials but in post-hoc analyses of psoriatic arthritis-related 'physicianreported spondylitis'?' by Braun and Landewe

Juergen Braun et al.

ANNALS OF THE RHEUMATIC DISEASES (2023)

Add to Collection

Letter Rheumatology

Correspondence on 'No efficacy of anti-IL-23 therapy for axial spondyloarthritis in randomised controlled trials but in post-hoc analyses of psoriatic arthritis-related 'physician-reported spondylitis'?' by Braun and Landewe

Dafna D. Gladman et al.

ANNALS OF THE RHEUMATIC DISEASES (2023)

Add to Collection

Editorial Material Rheumatology

No efficacy of anti-IL-23 therapy for axial spondyloarthritis in randomised controlled trials but in post-hoc analyses of psoriatic arthritis-related 'physician-reported spondylitis'?

Juergen Braun et al.

Summary: Three monoclonal antibodies targeting interleukin-23 have been approved for psoriasis treatment, with two also approved for psoriatic arthritis. However, they have shown to be ineffective in axial spondyloarthritis and may be due to generic effects rather than specific inflammation.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Add to Collection

Meeting Abstract Rheumatology

HAVE TREATMENTS FOR AUTOIMMUNE DISEASES WORSENED THE PROGNOSIS OF COVID-19 INFECTION?

A. I. Rebollo Gimenez et al.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Add to Collection

Article Rheumatology

Early identification of axial psoriatic arthritis among patients with psoriasis: a prospective multicentre study

Fabian Proft et al.

Summary: A dermatologist-centred screening tool followed by a structured rheumatological examination, including MRI, can be effective in recognizing psoriatic arthritis with axial involvement.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Add to Collection

Article Rheumatology

Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021

Laura C. Coates et al.

Summary: This article presents evidence-based treatment recommendations for Psoriatic Arthritis (PsA) medication selection, covering various clinical domains, related conditions and comorbidities. It provides important guidance and support for clinicians and individuals with PsA.

NATURE REVIEWS RHEUMATOLOGY (2022)

Add to Collection

Article Rheumatology

What is peripheral spondyloarthritis? Identifying proportion, phenotype and burden in post hoc analysis of the ASAS-PerSpA study

Nelly Ziade et al.

Summary: The study compared the phenotype and burden of pure peripheral spondyloarthritis to pure psoriatic arthritis, pure axial spondyloarthritis, and combined forms of spondyloarthritis. Pure pSpA patients had a high prevalence of peripheral joint disease, synovitis, enthesitis, positive HLA-B27, high C-Reactive Protein level, and inflammatory back pain. They had a significantly higher disease burden compared to pure PsA and pure axSpA.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2022)

Add to Collection

Article Rheumatology

Characterising the axial phenotype of psoriatic arthritis: a study comparing axial psoriatic arthritis and ankylosing spondylitis with psoriasis from the REGISPONSER registry

Xabier Michelena et al.

Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.

RMD OPEN (2022)

Add to Collection

Review Rheumatology

Peripheral spondyloarthritis and psoriatic arthritis sine psoriase: are we dealing with semantics or clinically meaningful differences?

Nelly Ziade et al.

Summary: Diagnosing peripheral spondyloarthritis (pSpA) and psoriatic arthritis sine psoriasis (PsA sine psoriase) requires distinguishing their differences in terms of gender, HLA genes, and joint involvement. Further research and randomized clinical trials are needed to better understand pSpA and identify effective therapies.

RMD OPEN (2022)

Add to Collection

Article Medicine, Research & Experimental

Efficacy and safety of guselkumab in biologic-naive patients with active axial psoriatic arthritis: study protocol for STAR, a phase 4, randomized, double-blinded, placebo-controlled trial

Dafna D. Gladman et al.

Summary: This study aims to evaluate the efficacy of guselkumab in reducing axial symptoms and inflammation in patients with active PsA.

TRIALS (2022)

Add to Collection

Article Rheumatology

Secukinumab in patients with psoriatic arthritis and axial manifestations: results from the double-blind, randomised, phase 3 MAXIMISE trial

Xenofon Baraliakos et al.

Summary: The MAXIMISE trial demonstrated that secukinumab significantly improved axial disease symptoms in patients with PsA, particularly those with inadequate response to NSAIDs.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Add to Collection

Article Medicine, General & Internal

Efficacy of tofacitinib in reduction of inflammation detected on MRI in patients with Psoriatic ArthritiS presenTing with axial involvement (PASTOR): protocol of a randomised, double-blind, placebo-controlled, multicentre trial

Fabian Proft et al.

Summary: Psoriatic arthritis (PsA) is an inflammatory disease characterized by synovitis, enthesitis, dactylitis and axial involvement. The efficacy of tofacitinib in reducing inflammation in axial PsA patients will be evaluated in a randomized, double-blind, placebo-controlled clinical trial involving 80 participants with active disease.

BMJ OPEN (2021)

Add to Collection

Article Rheumatology

Efficacy of guselkumab on axial involvement in patients with active psoriatic arthritis and sacroiliitis: a post-hoc analysis of the phase 3 DISCOVER-1 and DISCOVER-2 studies

Philip J Mease et al.

Lancet Rheumatology (2021)

Add to Collection

Article Rheumatology

Axial involvement in psoriatic arthritis: An update for rheumatologists

Denis Poddubnyy et al.

Summary: Psoriatic arthritis (PsA) is a chronic, inflammatory musculoskeletal disease with heterogeneous characteristics, and axial involvement can lead to complications in management and treatment decisions. The lack of agreed-upon classification and diagnostic criteria for axial PsA complicates the approach to this subset of patients.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2021)

Add to Collection

Article Rheumatology

Axial Involvement in Psoriatic Arthritis cohort (AXIS): the protocol of a joint project of the Assessment of SpondyloArthritis international Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)

Denis Poddubnyy et al.

Summary: The AXIS study aims to systematically evaluate clinical and imaging manifestations indicative of axial involvement in patients with PsA, in order to develop classification criteria and a unified nomenclature for defining a homogeneous subgroup of patients for research.

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2021)

Add to Collection

Article Rheumatology