4.5 Article

Patterns of clinical joint inflammation in juvenile idiopathic arthritis

Related references

Note: Only part of the references are listed.
Article Pediatrics

The efficacy and safety of intra-articular injection of triamcinolone acetonide versus triamcinolone hexacetonide for treatment of juvenile idiopathic arthritis

Shiri Rubin et al.

Summary: This study compared the efficacy and safety of triamcinolone acetonide (TA) and triamcinolone hexacetonide (TH) for juvenile idiopathic arthritis (JIA) patients. The results showed similar recovery rates for both regimens, but TA had a more than double relapse rate compared to TH.

PEDIATRIC RHEUMATOLOGY (2022)

Article Rheumatology

Joint inflammation tends to recur in the same joints during the rheumatoid arthritis disease course

Sascha L. Heckert et al.

Summary: In patients with rheumatoid arthritis, baseline joint swelling was significantly associated with swelling in the same joint during follow-up, and it was found to better predict local joint swelling compared to baseline swelling in other joints. This suggests that local factors play a role in the recurrence of joint swelling over time.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Article Rheumatology

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis

Karen B. Onel et al.

Summary: This article provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on different forms of JIA and providing recommendations for treatment and tapering of medications. The evidence for these recommendations is generally low quality, but the inclusion of patients and caregivers in the decision-making process strengthens the relevance and applicability of the guideline.

ARTHRITIS & RHEUMATOLOGY (2022)

Article Rheumatology

Joint-Specific Memory and Sustained Risk for New Joint Accumulation in Autoimmune Arthritis

Margaret H. Chang et al.

Summary: This study aims to identify patient-specific patterns of joint flare in inflammatory arthritides to distinguish local from systemic drivers of disease chronicity. The results showed that arthritis flares preferentially affect previously inflamed joints and carry an ongoing risk of disease extension. These findings confirm joint-specific memory and suggest that prevention of new joint accumulation should be an important target for arthritis therapy.

ARTHRITIS & RHEUMATOLOGY (2022)

Article Cell Biology

Arthritis flares mediated by tissue-resident memory T cells in the joint

Margaret H. Chang et al.

Summary: The recurrence of rheumatoid arthritis is mediated by long-lived synovial resident memory T cells (T-RM) activated by antigen, leading to the recruitment of circulating effector cells. Depletion of T-RM can ameliorate recurrence in a site-specific manner. Human rheumatoid arthritis joint tissues contain a CD8+-predominant T-RM population.

CELL REPORTS (2021)

Article Immunology

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Jasna Friscic et al.

Summary: Inflammation-mediated tissue priming causes recurrence and worsening of arthritis, involving molecular and cellular mechanisms. This priming occurs locally and independently of adaptive immunity, and can be enhanced by activating complement C3 and C3a receptor, along with other molecular pathways, to boost cellular metabolic activity and increase inflammation sensitivity.

IMMUNITY (2021)

Review Rheumatology

Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis

Eric Gracey et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

Article Pediatrics

No radiographic wrist damage after treatment to target in recent-onset juvenile idiopathic arthritis

P. C. E. Hissink Mullerlr et al.

PEDIATRIC RHEUMATOLOGY (2019)

Article Statistics & Probability

Exact testing with random permutations

Jesse Hemerik et al.

Article Statistics & Probability

Exact testing with random permutations

Jesse Hemerik et al.

Article Medicine, General & Internal

Juvenile idiopathic arthritis

Berent Prakken et al.

LANCET (2011)