Journal
HEALTHCARE
Volume 11, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/healthcare11121673
Keywords
size; thyroid nodule; thyroid cancer; American College of Radiology; TI-RADS; ultrasound; predictive factor; real-world observational study
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We investigated the predictive value of thyroid nodule size for malignancy and the consequences of following the ACR guidelines for FNAB. A retrospective observational study on 86 patients who underwent surgery was conducted. Sub-categories were created based on size thresholds for FNAB. The study did not find a significant difference in malignancy prediction between the sub-categories, suggesting that the utility of size thresholds in standardized thyroid work-up may be less clear than suggested by the ACR guidelines.
We investigated if thyroid nodule size has a predictive value of malignancy on a par with composition, echogenicity, shape, margin, and echogenic foci, and what would be the consequence of observing the rule of the American College of Radiology (ACR) to perform a fine-needle aspiration biopsy (FNAB). We conducted a retrospective real-life observational study on 86 patients who underwent surgery after a standardized diagnostic protocol. We divided the TR3, TR4, and TR5 classes into sub-classes according to the size threshold indicating FNAB (a: up to the threshold for no FNAB; b: over the threshold for FNAB suggested). We computed sensitivity, specificity, and positive (PPV) and negative predictive value (NPV) for the different sub-classes and Youden's index (Y) for the different possible cutoffs. Each sub-class showed the following PPV (0.67, 0.68, 0.70, 0.78, 0.72), NPV (0.56, 0.54, 0.51, 0.52, 0.59), and Y (0.20, 0.20, 0.22, 0.31, 0.30). In this real-life series, we did not find a significant difference in prediction of malignancy between the sub-categories according to the size threshold. All nodules have a pre-evaluation likelihood of being malignant, and the impact and utility of size thresholds may be less clear than suggested by the ACR TIRADS guidelines in patients undergoing standardized thyroid work up.
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