4.5 Review

Tozinameran (Pfizer, BioNTech) and Elasomeran (Moderna) Efficacy in COVID-19-A Systematic Review of Randomised Controlled Trial Studies

Related references

Note: Only part of the references are listed.
Article Immunology

A phase 1/2 randomised placebo-controlled study of the COVID-19 vaccine mRNA-1273 in healthy Japanese adults: An interim report

Taisei Masuda et al.

Summary: This study evaluated the safety and immunogenicity of mRNA-1273 vaccine in healthy Japanese participants. The results showed that two doses of 100 μg mRNA-1273 administered 28 days apart demonstrated an acceptable safety profile and induced significant anti-SARS-CoV-2 immune responses in a Japanese population aged >= 20 years.

VACCINE (2022)

Article Immunology

A preliminary report of a randomized controlled phase 2 trial of the safety and immunogenicity of mRNA-1273 SARS-CoV-2 vaccine

Laurence Chu et al.

Summary: The study evaluated the safety and immunogenicity of the mRNA-1273 vaccine in healthy adults, showing significant immune responses to SARS-CoV-2 with acceptable safety profile. This vaccine induced higher antibody levels at a 100 mg dose, confirming its immunogenicity and safety for use in a 2-dose regimen.

VACCINE (2021)

Article Multidisciplinary Sciences

A randomized study to evaluate safety and immunogenicity of the BNT162b2 COVID-19 vaccine in healthy Japanese adults

Miwa Haranaka et al.

Summary: The interim analysis of the ongoing study of the BNT162b2 vaccine in healthy Japanese adults showed that it has an acceptable safety profile and induces a robust immune response, regardless of age. The participants mainly experienced mild to moderate local reactions and no serious adverse events, with good antibody induction one month after the second dose.

NATURE COMMUNICATIONS (2021)

Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Medicine, General & Internal

Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase

H. M. El Sahly et al.

Summary: The mRNA-1273 vaccine demonstrated high efficacy in preventing COVID-19 illness and severe disease, with more than 5 months of protection and a good safety profile, including protection against asymptomatic infection.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months

S. J. Thomas et al.

Summary: BNT162b2 vaccine remains highly effective and safe over the course of 6 months post-vaccination, with efficacy rates ranging from 86% to 100% across different demographics and risk factors for Covid-19. The vaccine also shows a high efficacy against severe disease, with particularly promising results observed in South Africa against the B.1.351 variant.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Infectious Diseases

Safety of SARS-CoV-2 vaccines: a systematic review and meta-analysis of randomized controlled trials

Musha Chen et al.

Summary: A systematic review and meta-analysis found that the safety and tolerance of current COVID-19 vaccine candidates are acceptable for mass vaccination, with inactivated COVID-19 vaccines candidates having the lowest reported adverse events following immunization (AEFI). Long-term surveillance of vaccine safety is required, especially among elderly people with underlying medical conditions.

INFECTIOUS DISEASES OF POVERTY (2021)

Review Immunology

Safety and Efficacy of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Different Vaccines at Phase 3

Yu-Jing Fan et al.

Summary: This systematic review and meta-analysis compared the safety and efficacy of COVID-19 vaccines, finding that mRNA vaccines were more associated with serious adverse events, while two doses of mRNA vaccines were most effective in reducing the risk of SARS-COV-2 infection. All vaccines were effective in reducing the risk of severe infection.

VACCINES (2021)

Review Virology

Coronavirus disease 2019: What we know?

Feng He et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Article Critical Care Medicine

Randomized Controlled Trials

Emily C. Zabor et al.

CHEST (2020)

Article Medicine, General & Internal

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

Edward E. Walsh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)