Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants

This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their potential implementation as early biomarkers. Moreover, we address the impact that all the mechanisms triggered by sepsis have on the dysbiosis and the changes on neonatal microbiota.

Automated summary

This narrative review discusses the mechanisms of bacterial sepsis in preterm infants, a prevalent and serious illness. It examines the role of the innate immune response and oxidative stress in the pathogenesis and their potential as early biomarkers. Furthermore, it addresses the impact of sepsis-induced mechanisms on dysbiosis and changes in neonatal microbiota.