Journal
LUNG CANCER
Volume 102, Issue -, Pages 38-41Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2016.10.012
Keywords
ALK translocation; Lung neoplasms; Small cell cancer transformation
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Various mechanisms of resistance to ALK inhibitors in ALK rearranged adenocarcinomas are reported including secondary gatekeeper mutations, bypass signaling or ALK amplifications as the commonest ones. We report a new mechanism of resistance with transformation of adenocarcinoma into small cell lung cancer. A 53-year-old non-smoker woman, experienced cancer progression after two lines of ALK inhibitors. A new biopsy showed a small cell lung cancer. FISH revealed persistent ALK rearrangement with an atypical pattern and complete loss of the 5' region of the ALK gene. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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