4.6 Review

Greener Grass: The Modern History of Epithelial Stem Cell Innovation

Journal

LIFE-BASEL
Volume 13, Issue 3, Pages -

Publisher

MDPI
DOI: 10.3390/life13030688

Keywords

stem cells; epithelia; p63; cultured epithelial autografts; holoclones; repsox; howard green; transforming growth factor beta

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The work of American scientist Howard Green has had a profound impact on the field of epithelial stem cell development, as his breakthroughs in stem cell culture methods have been translated into therapeutic practice. This review chronicles the milestones that have propelled the field of regenerative medicine for the skin forward over the past fifty years. It details Green's early discoveries, highlights clinical cases that have made life-saving use of his findings, and discusses the achievements of other scientists who built upon his discoveries.
The field of epithelial stem cell development has been irrevocably shaped by the work of American scientist Howard Green, whose breakthroughs in stem cell culture methods translated to therapeutic practice. In this review, we chronicle the milestones that propelled the field of regenerative medicine of the skin forward over the last fifty years. We detail the early discoveries made by Green and his collaborators, highlight clinical cases that made life-saving use of his findings, and discuss the accomplishments of other scientists who later innovated upon his discoveries.

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