Sex and Age-Dependent Olfactory Memory Dysfunction in ADHD Model Mice

ADHD is a typical neurodevelopmental disorder with a high prevalence rate. NSCs in the subventricular zone (SVZ) are closely related to neurodevelopmental disorder and can affect olfactory function by neurogenesis and migratory route. Although olfactory dysfunction is one of the symptoms of ADHD, the relevance of cells in the olfactory bulb derived from NSCs has not been studied. Therefore, we investigated olfactory memory and NSCs in Git1-deficient mice, under the ADHD model. Interestingly, only adult male G protein-coupled receptor kinase-interacting protein-1 (GIT1)-deficient (+/-, HE) mice showed impaired olfactory memory, suggesting sex and age dependence. We performed adult NSCs culture from the SVZ and observed distinct cell population in both sex and genotype. Taken together, our study suggests that the altered differentiation of NSCs in GIT1+/- mice can contribute to olfactory dysfunction in ADHD.

Automated summary

ADHD is a common neurodevelopmental disorder, and NSCs in the SVZ can affect olfactory function. However, the relevance of NSCs in the olfactory bulb to ADHD has not been studied. Our research on Git1-deficient mice revealed impaired olfactory memory in adult male mice, suggesting sex and age dependence. We cultured NSCs from the SVZ and observed distinct cell populations in both sexes and genotypes. This study suggests that altered NSC differentiation in Git1+/- mice may contribute to olfactory dysfunction in ADHD.