4.6 Review

Systemic Associations with Keratoconus

Related references

Note: Only part of the references are listed.
Article Ophthalmology

Corneal Biomechanical Characteristics in Osteogenesis Imperfecta With Collagen Defect

Chien-Chih Chou et al.

Summary: This study compared the corneal biomechanical properties between patients with osteogenesis imperfecta (OI) and keratoconus. The results showed significant differences in corneal biomechanical parameters between OI patients and normal controls, as well as between OI patients and keratoconus patients. This suggests that OI and keratoconus have different alterations in corneal biomechanical properties.

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2023)

Review Ophthalmology

Diabetes Mellitus and Keratoconus: A Systematic Review and Meta-Analysis

Xing-Xuan Dong et al.

Summary: This study conducted a systematic review and meta-analysis to investigate the association between diabetes and keratoconus. The results indicated that there is no significant association between diabetes and keratoconus.

CORNEA (2022)

Review Ophthalmology

Association between diabetes and keratoconus-a systematic review and meta-analysis

Prince K. Akowuah et al.

Summary: The meta-analysis found no significant association between diabetes mellitus and keratoconus, although further well-designed longitudinal prospective studies are needed to investigate this potential relationship.

EUROPEAN JOURNAL OF OPHTHALMOLOGY (2022)

Article Ophthalmology

Nationwide epidemiological approach to identify associations between keratoconus and immune-mediated diseases

Janneau L. J. Claessens et al.

Summary: The study found novel associations between keratoconus and Hashimoto's thyroiditis as well as inflammatory skin conditions. It also confirmed known associations with atopic conditions such as allergic rash, asthma, bronchial hyperresponsiveness, and allergic rhinitis. The positive association between keratoconus and multiple immune-mediated diseases suggests that systemic inflammatory responses may play a role in its onset.

BRITISH JOURNAL OF OPHTHALMOLOGY (2022)

Article Ophthalmology

Pathogenesis of keratoconus: NRF2-antioxidant, extracellular matrix and cellular dysfunctions

Maithe Rocha Monteiro de Barros et al.

Summary: Keratoconus is a degenerative disease with unknown pathophysiology. Recent studies have found dysregulations in oxidative stress and cellular and extracellular matrix functions. Further research is needed to identify relevant genes and develop biomarkers and therapeutic targets.

EXPERIMENTAL EYE RESEARCH (2022)

Review Biochemistry & Molecular Biology

The Underlying Relationship between Keratoconus and Down Syndrome

Theresa Akoto et al.

Summary: This review examines the relationship between keratoconus and Down Syndrome, aiming to provide a better understanding of keratoconus in Down Syndrome patients and promote research to improve their vision and identify effective treatment strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Cardiac & Cardiovascular Systems

Mitral valve prolapse: From new mechanisms to diagnostic challenges

Idit Tessler et al.

Summary: Mitral valve prolapse (MVP) is the most common primary valvular abnormality, associated with various degrees of incompetent function and sequelae, including heart failure and sudden cardiac death. Recent advancements in echocardiographic techniques and understanding of mitral valve anatomy and physiology have improved the accuracy and reliability of MVP diagnosis.

KARDIOLOGIA POLSKA (2022)

Article Ophthalmology

New Keratoconus Risk Factors: A Cross-Sectional Case-Control Study

Eloi Debourdeau et al.

Summary: This study evaluated the risk factors associated with keratoconus and found significant associations with family history, eye rubbing, allergy, smoking exposure, and dry eyes. The study also highlighted the role of pressure on the eyes during sleep as an important factor.

JOURNAL OF OPHTHALMOLOGY (2022)

Article Immunology

Independent and interactive effects of eye rubbing and atopy on keratoconus

Kaili Yang et al.

Summary: Eye rubbing and atopy are separately positively associated with KC, and the coexistence of eye rubbing and atopy has a significant impact on KC.

FRONTIERS IN IMMUNOLOGY (2022)

Article Ophthalmology

The prevalence of keratoconus in children with allergic eye disease in an Egyptian population

Alyaa Saeed Ahmed et al.

Summary: The prevalence of KC among children with ocular allergy was 34%. Risk factors for developing KC in these patients included age, duration of symptoms especially eye rubbing, systemic atopy, and VKC. Tomographic diagnosis of KC can be made in the absence of clinical signs.

EUROPEAN JOURNAL OF OPHTHALMOLOGY (2021)

Article Ophthalmology

The Sociodemographic and Risk Factors for Keratoconus: Nationwide Matched Case- Control in 1998-2015

Ken-Kuo Lin et al.

Summary: The study identified sociodemographic and risk factors for keratoconus patients using a nationwide Asian database. Hyperlipidemia, depression, and diabetes mellitus were negatively associated with keratoconus, while asthma, allergic rhinitis, astigmatism, myopia, and Down syndrome were positively associated.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2021)

Article Ophthalmology

Corneal and conjunctival alteration of innate immune expression in first-degree relatives of keratoconus patients

Uxia Regueiro et al.

Summary: The study found that TLR2/TLR4 expression showed a significant gradual increase among control subjects, first-degree relatives, and KC patients. This suggests that TLR2/TLR4 may be related to the pathophysiology of KC.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2021)

Review Surgery

Application of Collagen I and IV in Bioengineering Transparent Ocular Tissues

Yihui Song et al.

Summary: Collagens are a major group of structural proteins expressed in various tissues, with different types having unique properties. In ocular tissues, collagen types I and IV play crucial roles in maintaining structure and transparency necessary for clear vision. This review explores the application of these collagens as biomaterials in bioengineering for treating ocular diseases that can lead to blindness.

FRONTIERS IN SURGERY (2021)

Article Ophthalmology

Update on the genetics of keratoconus

Yelena Bykhovskaya et al.

Summary: Recent advancements in the field of keratoconus have led to the discovery of new susceptibility variants, biological pathways and improved methods for predicting treatment outcomes. The latest research has also identified tissue-specific effects of coding genes and introduced genomic medicine into clinical practice for keratoconus.

EXPERIMENTAL EYE RESEARCH (2021)

Review Ophthalmology

Eye rubbing in the aetiology of keratoconus: a systematic review and meta-analysis

Srujana Sahebjada et al.

Summary: Eye rubbing is consistently associated with keratoconus, but current evidence is limited to a small number of case-control studies that are heterogeneous and of sub-optimal methodological quality. Further research is needed to explore the intricate relationship between eye rubbing and the induction, ongoing progression, and severity of keratoconus.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2021)

Article Ophthalmology

Correlation between Keratoconus and Pollution

Tristan Jurkiewicz et al.

Summary: The study found that fine particulate matter may be an emerging risk factor for keratoconus, with a moderate to strong correlation with the prevalence of the disease. Fine particulate matter is thought to indirectly impact keratoconus by exacerbating other risk factors such as atopy and eye rubbing, and it may also have a direct effect on the cornea.

OPHTHALMIC EPIDEMIOLOGY (2021)

Article Biochemistry & Molecular Biology

Resequencing of candidate genes for Keratoconus reveals a role for Ehlers-Danlos Syndrome genes

Erik Fransen et al.

Summary: This study identified an enrichment of genetic variation in genes including COL2A1, COL5A1, TNXB and ZNF469 in patients with KC. The top hit was found in a common variant in the COL12A1 gene. Interestingly, genes associated with Ehlers-Danlos Syndrome (EDS) were also implicated in the etiology of KC, suggesting a shared genetic etiology between the two conditions.

EUROPEAN JOURNAL OF HUMAN GENETICS (2021)

Article Ophthalmology

Estimated Prevalence of Keratoconus in the United States From a Large Vision Insurance Database

Saleha Z. Munir et al.

Summary: The prevalence of keratoconus among VSP enrollees in the United States was estimated to be 0.15%, with the highest prevalence in Western states and among male population. In Colorado, particularly high prevalence was observed in men aged 18 to 39 and 40 to 64.

EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE (2021)

Article Multidisciplinary Sciences

Corneal transplantation for keratoconus in South Korea

Sungsoon Hwang et al.

Summary: This study found that the incidence rate of corneal transplantation in patients with keratoconus was relatively low in South Korea compared to other countries. Male sex, severe atopic dermatitis, obstructive sleep apnea, and intellectual disability were significantly associated with an increased risk of progression to corneal transplantation in patients with keratoconus.

SCIENTIFIC REPORTS (2021)

Article Ophthalmology

Risk factors for progression following corneal collagen crosslinking in keratoconus

Ayhan Saglik et al.

Summary: This study found that risk factors for progression following corneal collagen crosslinking (CXL) in eyes with keratoconus include age under 17, female gender, allergic conjunctivitis, high preoperative Kmax, and thin corneas. The majority of progressive patients were central cone and moderate keratoconus.

INTERNATIONAL OPHTHALMOLOGY (2021)

Review Ophthalmology

Prevalence of keratoconus in persons with Down syndrome: a review

Olav Kristianslund et al.

Summary: The prevalence of keratoconus in individuals with Down syndrome is higher than in the general population, but estimates from previous studies vary widely. Screening for keratoconus in this group should be considered.

BMJ OPEN OPHTHALMOLOGY (2021)

Review Ophthalmology

Pediatric keratoconus - Current perspectives and clinical challenges

Venugopal Anitha et al.

Summary: Pediatric keratoconus is a progressive corneal disease that significantly impacts quality of life and educational development. Early diagnosis and timely intervention are key, with management differing from adults.

INDIAN JOURNAL OF OPHTHALMOLOGY (2021)

Article Ophthalmology

Keratoconus detection by novel indices in patients with Down syndrome: a cohort population-based study

Hassan Hashemi et al.

JAPANESE JOURNAL OF OPHTHALMOLOGY (2020)

Article Ophthalmology

Keratoconus and corneal morphology in patients with Down syndrome at a pediatric hospital

Lauren M. Imbornoni et al.

JOURNAL OF AAPOS (2020)

Article Medicine, General & Internal

Down syndrome

Stylianos E. Antonarakis et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Review Cardiac & Cardiovascular Systems

Marfan syndrome revisited: From genetics to the clinic

Sonia Gomes Coelho et al.

REVISTA PORTUGUESA DE CARDIOLOGIA (2020)

Review Neurosciences

Genetic and Environmental Risk Factors for Keratoconus

Sionne E. M. Lucas et al.

ANNUAL REVIEW OF VISION SCIENCE, VOL 6, 2020 (2020)

Review Medicine, General & Internal

Down Syndrome

Marilyn J. Bull

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Ophthalmology

Topographic screening reveals keratoconus to be extremely common in Down syndrome

Joyce J. Mathan et al.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2020)

Article Environmental Sciences

Risk of Mitral Valve Prolapse in Patients with Keratoconus in Taiwan: A Population-Based Cohort Study

Yuh-Shin Chang et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

Article Ophthalmology

Tomography-based definition of keratoconus for Down syndrome patients

Soheila Asgari et al.

EYE AND VISION (2020)

Article Cardiac & Cardiovascular Systems

The Association Between Keratoconus and Mitral Valve Prolapse: A Meta-Analysis

Juan A. Siordia et al.

CURRENT CARDIOLOGY REVIEWS (2020)

Review Cell Biology

Mechanisms of Collagen Crosslinking in Diabetes and Keratoconus

Tina B. McKay et al.

CELLS (2019)

Article Ophthalmology

Corneal Morphologic Characteristics in Patients With Down Syndrome

Jorge L. Alio et al.

JAMA OPHTHALMOLOGY (2018)

Article Ophthalmology

Case-control study of risk factors for acute corneal hydrops in keratoconus

Allon Barsam et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2017)

Article Ophthalmology

Effect of Allergic Diseases on Keratoconus Severity

Mohammad Naderan et al.

OCULAR IMMUNOLOGY AND INFLAMMATION (2017)

Article Endocrinology & Metabolism

Corneal thickness differences between type 2 diabetes and non-diabetes subjects during preoperative laser surgery examination

Juan A. Sanchis-Gimeno et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2017)

Review Genetics & Heredity

Genetic factors influencing the reduction of central corneal thickness in disorders affecting the eye

Joanna Swierkowska et al.

OPHTHALMIC GENETICS (2017)

Article Genetics & Heredity

The 2017 International Classification of the Ehlers-Danlos Syndromes

Fransiska Malfait et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS (2017)

Article Ophthalmology

Age-specific Incidence and Prevalence of Keratoconus: A Nationwide Registration Study

Daniel A. Godefrooij et al.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2017)

Article Ophthalmology

Risk factors for keratoconus in Israel: a case-control study

Ariela Gordon-Shaag et al.

OPHTHALMIC AND PHYSIOLOGICAL OPTICS (2015)

Article Ophthalmology

Characteristics and associations of keratoconus patients

Mohammad Naderan et al.

CONTACT LENS & ANTERIOR EYE (2015)

Article Ophthalmology

Rate of Corneal Collagen Crosslinking Redo in Private Practice: Risk Factors and Safety

Joelle Antoun et al.

JOURNAL OF OPHTHALMOLOGY (2015)

Article Ophthalmology

Association Between Diabetes and Keratoconus: A Case-Control Study

Mohammad Naderan et al.

CORNEA (2014)

Article Ophthalmology

Another Look at the Association Between Diabetes and Keratoconus

Mustafa Kosker et al.

CORNEA (2014)

Review Ophthalmology

Epigenetic Mechanisms Might Help Explain Environmental Contributions to the Pathogenesis of Keratoconus

Charles W. McMonnies

EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE (2014)

Article Biochemistry & Molecular Biology

Enrichment of pathogenic alleles in the brittle cornea gene, ZNF469, in keratoconus

Judith Lechner et al.

HUMAN MOLECULAR GENETICS (2014)

Article Endocrinology & Metabolism

Osteogenesis Imperfecta: Diagnosis and Treatment

A. Biggin et al.

CURRENT OSTEOPOROSIS REPORTS (2014)

Article Ophthalmology

The Auckland keratoconus study: Identifying predictors of acute corneal hydrops in keratoconus

Jennifer C. Fan Gaskin et al.

CLINICAL AND EXPERIMENTAL OPTOMETRY (2013)

Review Ophthalmology

Insights into keratoconus from a genetic perspective

Kathryn P. Burdon et al.

CLINICAL AND EXPERIMENTAL OPTOMETRY (2013)

Article Ophthalmology

Effects of eye rubbing on the levels of protease, protease activity and cytokines in tears: relevance in keratoconus

Sivaraman A. Balasubramanian et al.

CLINICAL AND EXPERIMENTAL OPTOMETRY (2013)

Article Ophthalmology

Keratoplasty Postoperative Treatment Update

Machiko Shimmura-Tomita et al.

CORNEA (2013)

Article Ophthalmology

Ocular allergy and keratoconus

Namrata Sharma et al.

INDIAN JOURNAL OF OPHTHALMOLOGY (2013)

Review Clinical Neurology

The impairment of lysyl oxidase in keratoconus and in keratoconus-associated disorders

Lubica Dudakova et al.

JOURNAL OF NEURAL TRANSMISSION (2013)

Article Ophthalmology

Corneal curvature, pachymetry, and endothelial cell density in Marfan syndrome

Tiina R. Konradsen et al.

ACTA OPHTHALMOLOGICA (2012)

Article Ophthalmology

Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus

Sivaraman Arumugam Balasubramanian et al.

ACTA OPHTHALMOLOGICA (2012)

Article Ophthalmology

The Role of Atopy in Corneal Graft Survival in Keratoconus

Jacob K. Thomas et al.

CORNEA (2011)

Article Ophthalmology

Prevalence and Associated Factors of Keratoconus in Jerusalem: A Cross-sectional Study

Michel Millodot et al.

OPHTHALMIC EPIDEMIOLOGY (2011)

Article Ophthalmology

The Association of Keratoconus With Immune Disorders

Arie Y. Nemet et al.

CORNEA (2010)

Article Ophthalmology

ATOPY AND HLA ANTIGENS IN PATIENTS WITH KERATOCONUS

LILLEMOR WACHTMEISTER et al.

ACTA OPHTHALMOLOGICA (2009)

Article Ophthalmology

Changes of extracellular matrix of the cornea in diabetes mellitus

A. Hager et al.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2009)

Article Ophthalmology

Effect of diabetes mellitus on biomechanical parameters of the cornea

Yakov Goldich et al.

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2009)

Article Ophthalmology

Incidence of ocular pathologies in Italian children with Down syndrome

F. Fimiani et al.

EUROPEAN JOURNAL OF OPHTHALMOLOGY (2007)

Article Ophthalmology

Is there an association between diabetes and keratoconus?

IC Kuo et al.

OPHTHALMOLOGY (2006)

Article Ophthalmology

Computerized corneal topography in a paediatric population with Down syndrome

AL Vincent et al.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2005)

Article Ophthalmology

Acute corneal hydrops treated by intracameral injection of perfluoropropane (C3F8) gas

SG Shah et al.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2005)

Article Ophthalmology

Biometric measurements of the eyes in teenagers and young adults with Down syndrome

OH Haugen et al.

ACTA OPHTHALMOLOGICA SCANDINAVICA (2001)

Article Ophthalmology

Manifest diabetes and keratoconus: A retrospective case-control study

T Seiler et al.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2000)

Article Ophthalmology

Atopy and keratoconus: a multivariate analysis

AM Bawazeer et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2000)

Article Ophthalmology

Keratoconus and mitral valve prolapse

H Lichter et al.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2000)