Framing of Poly(arylene-ethynylene) around Carbon Nanotubes and Iodine Doping for the Electrochemical Detection of Dopamine

Dopamine (DA), an organic biomolecule that acts as both a hormone and a neurotransmitter, is essential in regulating emotions and metabolism in living organisms. The accurate determination of DA is important because it indicates early signs of serious neurological disorders. Covalent organic frameworks (COFs) and metal-organic frameworks (MOFs) have received considerable attention in recent years as promising porous materials with an unrivaled degree of tunability for electrochemical biosensing applications. This study adopted a solvothermal strategy for the synthesis of a conjugated microporous poly(arylene ethynylene)-4 (CMP-4) network using the Sonagashira-Hagihara cross-coupling reaction. To increase the crystallinity and electrical conductivity of the material, CMP-4 was enveloped around carbon nanotubes (CNTs), followed by iodine doping. When used as an electrochemical probe, the as-synthesized material (I-2-CMP-CNT-4) exhibited excellent selectivity and sensitivity to dopamine in the phosphate-buffered solution. The detection limits of the electrochemical sensor were 1 and 1.7 mu M based on cyclic voltammetry (CV) and differential pulse voltammetry (DPV).

Automated summary

Dopamine, an organic biomolecule with hormone and neurotransmitter functions, plays a crucial role in regulating emotions and metabolism in organisms. Accurate determination of dopamine is important for early diagnosis of neurological disorders. This study focused on the synthesis of a conjugated microporous poly(arylene ethynylene)-4 (CMP-4) network using a solvothermal strategy and demonstrated its excellent selectivity and sensitivity as an electrochemical probe for dopamine detection in a phosphate-buffered solution.