4.7 Review

Aptamer-Based Point-of-Care Devices: Emerging Technologies and Integration of Computational Methods

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Summary: This study developed a simple synthesis method for graphene quantum dots to detect p24-HIV protein in disposable screen-printed electrodes, enabling early diagnosis of HIV with a wide detection range and high sensitivity. The device has been successfully applied to contaminated serum, accurately identifying real samples and providing a new method for rapid disease detection.

ANALYTICA CHIMICA ACTA (2021)

Article Chemistry, Analytical

Metal-Organic Framework-Functionalized Paper-Based Electrochemical Biosensor for Ultrasensitive Exosome Assay

Xiaojuan Liu et al.

Summary: The combination of a metal-organic framework-functionalized paper and a screen-printed electrode has enabled the development of a simple and cost-efficient electrochemical biosensor for detecting cancer-derived exosomes with high sensitivity and a low detection limit. This label-free paper-based biosensor offers advantages such as low cost, ease of operation, and high sensitivity, making it suitable for point-of-care diagnosis in resource-limited settings.

ANALYTICAL CHEMISTRY (2021)

Article Biophysics

Aptamer-based lateral flow assay on-site biosensors

Lei Huang et al.

Summary: The lateral flow assay (LFA) is a widely used paper-based on-site biosensor for detecting target analytes in minutes. Aptamers, as biorecognition molecules, are being explored as an alternative to antibodies in LFAs, offering advantages over traditional methods. Different formats of aptamer-based LFAs can achieve on-site detection of target analytes efficiently.

BIOSENSORS & BIOELECTRONICS (2021)

Review Chemistry, Analytical

Capture-SELEX for aptamer selection: A short review

Chen Lyu et al.

Summary: The emerging aptamer through SELEX, especially Capture-SELEX for small molecule selection, has shown significant potential, but also faces limitations that require further research and improvement.

TALANTA (2021)

Review Chemistry, Analytical

Mapping the gaps in chemical analysis for the characterisation of aptamer-target interactions

Elise Daems et al.

Summary: Aptamers are versatile biorecognition elements with wide applicability, requiring thorough characterization of their binding performance in the presence of the target for successful use. Various multi-analytical approaches are available to understand the aptamer-target interaction, highlighting the importance of considering the final application and limitations of analytical tools in the characterisation process.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

A simple label-free electrochemical sensor for sensitive detection of alpha-fetoprotein based on specific aptamer immobilized platinum nanoparticles/carboxylated-graphene oxide

Jantima Upan et al.

Summary: A label-free electrochemical aptamer-based sensor was developed for AFP detection, utilizing a PtNPs/GO-COOH modified platform with an AFP aptamer as the recognition element. The sensor demonstrated good sensitivity, selectivity, and stability for sensitive detection of AFP in serum samples.

SCIENTIFIC REPORTS (2021)

Review Nanoscience & Nanotechnology

Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing

Bhaskar Das et al.

Summary: Nanozymes have attracted attention for their ability to mimic natural enzymes while overcoming their limitations. They offer advantages such as diverse activities, low cost, high stability, and compatibility, making them suitable for various biosensing applications. Their integration in point-of-care diagnostics shows potential, although challenges remain in achieving truly ASSURED solutions.

NANO-MICRO LETTERS (2021)

Review Biochemistry & Molecular Biology

Near-Infrared-Triggered Upconverting Nanoparticles for Biomedicine Applications

Manoj Kumar Mahata et al.

Summary: The article reviews the progress and potential of lanthanide-doped upconverting nanoparticles in biomedical applications, focusing on their applications in optogenetics, oncotherapy, bioimaging, etc. The unique properties of UCNPs make them accurate, sensitive, multifunctional nanoprobes, leading to significant advancements in therapy and diagnosis. Emerging bioapplications and challenges in clinical translation of UCNP-based nanotechnology research are also discussed.

BIOMEDICINES (2021)

Review Nanoscience & Nanotechnology

Biosensors and sensors for dopamine detection

Xixia Liu et al.

Summary: Dopamine is a critical neurotransmitter in the human central nervous system, and abnormalities in its release are associated with neurological diseases and depression. Current methods for dopamine detection focus on electrochemical detection, fluorescent and colorimetric sensors, with promising advances in combining aptamers or molecularly imprinted polymers to improve detection speed and selectivity.
Review Chemistry, Multidisciplinary

Recent progress in sensing application of metal nanoarchitecture-enhanced fluorescence

Meiling Wang et al.

Summary: Fluorescence analytical methods offer advantages of high sensitivity/selectivity, but conventional assays have limitations. Metal nanoarchitecture-enhanced fluorescence can improve sensor performance and has been widely studied and applied in various fields.

NANOSCALE ADVANCES (2021)

Review Materials Science, Multidisciplinary

Smart materials-integrated sensor technologies for COVID-19 diagnosis

Ozgecan Erdem et al.

Summary: This study discusses the application of smart materials in the diagnosis of COVID-19, highlighting their advantages in improving sensitivity, linear dynamic range, and specificity, and pointing out some limitations and barriers of traditional detection methods.

EMERGENT MATERIALS (2021)

Article Biophysics

Ultrasensitive aptamer-based protein assays based on one-dimensional core-shell nanozymes

Rui Zhang et al.

BIOSENSORS & BIOELECTRONICS (2020)

Article Biochemical Research Methods

An aptamer-based colorimetric lateral flow assay for the detection of human epidermal growth factor receptor 2 (HER2)

Velu Ranganathan et al.

ANALYTICAL BIOCHEMISTRY (2020)

Article Chemistry, Analytical

Localized surface plasmon resonance aptasensor for the highly sensitive direct detection of cortisol in human saliva

Seongjae Jo et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

Review Chemistry, Analytical

Design strategies of AuNPs-based nucleic acid colorimetric biosensors

Tao Yang et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2020)

Article Biochemical Research Methods

Lateral flow assay using aptamer-based sensing for on-site detection of dopamine in urine

Shima Dalirirad et al.

ANALYTICAL BIOCHEMISTRY (2020)

Review Chemistry, Analytical

Lateral flow assays towards point -of -care cancer detection: A review of current progress and future trends

Tohid Mahmoudi et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2020)

Review Chemistry, Analytical

Recent Progress in Optical Sensors for Biomedical Diagnostics

Muqsit Pirzada et al.

MICROMACHINES (2020)

Article Chemistry, Multidisciplinary

Entangled Nanoplasmonic Cavities for Estimating Thickness of Surface-Adsorbed Layers

Amideddin Mataji-Kojouri et al.

ACS NANO (2020)

Review Biotechnology & Applied Microbiology

The research of aptamer biosensor technologies for detection of microorganism

Jiecan Yi et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Biophysics

Artificial intelligence biosensors: Challenges and prospects

Xiaofeng Jin et al.

BIOSENSORS & BIOELECTRONICS (2020)

Review Chemistry, Analytical

Aptasensors as promising new tools in bisphenol A detection - An invisible pollution in food and environment

Seyed-Hossein Rajabnejad et al.

MICROCHEMICAL JOURNAL (2020)

Article Materials Science, Multidisciplinary

Aptamer-embedded DNA origami cage for detecting (glycated) hemoglobin with a surface plasmon resonance sensor

Surachet Duanghathaipornsuk et al.

MATERIALS LETTERS (2020)

Article Materials Science, Multidisciplinary

Enhancing the nanoplasmonic signal by a nanoparticle sandwiching strategy to detect viruses

Fatih Inci et al.

APPLIED MATERIALS TODAY (2020)

Review Chemistry, Analytical

Aptasensors for Point-of-Care Detection of Small Molecules

Marc Prante et al.

BIOSENSORS-BASEL (2020)

Article Chemistry, Physical

Theoretical Insight on the Biosensing Applications of 2D Materials

Antara Vaidyanathan et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2020)

Article Multidisciplinary Sciences

Ultrasensitive antibody-aptamer plasmonic biosensor for malaria biomarker detection in whole blood

Antonio Minopoli et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Multidisciplinary

Aptamer-Based Lateral Flow Biosensor for Rapid Detection of Salivary Cortisol

Shima Dalirirad et al.

ACS OMEGA (2020)

Article Nanoscience & Nanotechnology

Point-of-Care Platform for Early Diagnosis of Parkinson's Disease

Soochan Kim et al.

ACS APPLIED BIO MATERIALS (2020)

Review Biochemistry & Molecular Biology

Methods and Applications of In Silico Aptamer Design and Modeling

Andrey A. Buglak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Chemistry, Multidisciplinary

Comparison of molecularly imprinted plasmonic nanosensor performances for bacteriophage detection

Ozgecan Erdem et al.

NEW JOURNAL OF CHEMISTRY (2020)

Review Chemistry, Analytical

Silver Nanoparticles as Colorimetric Sensors for Water Pollutants

Paolo Prosposito et al.

CHEMOSENSORS (2020)

Review Chemistry, Multidisciplinary

The Optoelectronic Nose: Colorimetric and Fluorometric Sensor Arrays

Zheng Li et al.

CHEMICAL REVIEWS (2019)

Article Chemistry, Multidisciplinary

Nanoscale ATP-Responsive Zeolitic Imidazole Framework-90 as a General Platform for Cytosolic Protein Delivery and Genome Editing

Xiaoti Yang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Biochemistry & Molecular Biology

Recent Advances in Aptamer Discovery and Applications

Yang Zhang et al.

MOLECULES (2019)

Review Chemistry, Multidisciplinary

Recent Advances on Electrochemical Biosensing Strategies toward Universal Point-of-Care Systems

Yifan Dai et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Biophysics

Label-free and reagentless capacitive aptasensor for thrombin

Hsin-Ju Chen et al.

BIOSENSORS & BIOELECTRONICS (2019)

Article Biochemistry & Molecular Biology

Molecular Simulations with in-deMon2k QM/MM, a Tutorial-Review

Aurelien de la Lande et al.

MOLECULES (2019)

Article Spectroscopy

Optical aptasensor based on silver nanoparticles for the colorimetric detection of adenosine

Shila Yousefi et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2019)

Review Biotechnology & Applied Microbiology

Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes

Nan Cheng et al.

TRENDS IN BIOTECHNOLOGY (2019)

Article Chemistry, Analytical

The Arsenic-Binding Aptamer Cannot Bind Arsenic: Critical Evaluation of Aptamer Selection and Binding

Chenghua Zong et al.

ANALYTICAL CHEMISTRY (2019)

Review Chemistry, Analytical

Aptamer and nanomaterial based FRET biosensors: a review on recent advances (2014-2019)

Zeki Semih Pehlivan et al.

MICROCHIMICA ACTA (2019)

Review Biophysics

FOrster resonance energy transfer (FRET)-based biosensors for biological applications

Xiaojing Zhang et al.

BIOSENSORS & BIOELECTRONICS (2019)

Review Biotechnology & Applied Microbiology

Plasmonic-based platforms for diagnosis of infectious diseases at the point-of-care

Zihan Li et al.

BIOTECHNOLOGY ADVANCES (2019)

Review Biotechnology & Applied Microbiology

Evolution of multi-functional capillary electrophoresis for high-efficiency selection of aptamers

Chao Zhu et al.

BIOTECHNOLOGY ADVANCES (2019)

Review Biochemistry & Molecular Biology

Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application

Tatsuo Adachi et al.

MOLECULES (2019)

Review Chemistry, Multidisciplinary

Advanced Carbon for Flexible and Wearable Electronics

Chunya Wang et al.

ADVANCED MATERIALS (2019)

Review Pathology

Label-free plasmonic biosensors for point-of-care diagnostics: a review

Maria Soler et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2019)

Article Nanoscience & Nanotechnology

In vivo SELEX of bone targeting aptamer in prostate cancer bone metastasis model

Lingxiao Chen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Article Materials Science, Biomaterials

Cell-SELEX, an Effective Way to the Discovery of Biomarkers and Unexpected Molecular Events

Tao Bing et al.

ADVANCED BIOSYSTEMS (2019)

Review Materials Science, Multidisciplinary

From DFT to machine learning: recent approaches to materials science-a review

Gabriel R. Schleder et al.

JOURNAL OF PHYSICS-MATERIALS (2019)

Article Chemistry, Analytical

Hand-Held Volatilome Analyzer Based on Elastically Deformable Nanofibers

Muge Yucel et al.

ANALYTICAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Systematic evaluation of cell-SELEX enriched aptamers binding to breast cancer cells

Laia Civit et al.

BIOCHIMIE (2018)

Review Biotechnology & Applied Microbiology

Point-of-Care Devices Using Disease Biomarkers To Diagnose Neurodegenerative Disorders

Ting-Yen Wei et al.

TRENDS IN BIOTECHNOLOGY (2018)

Review Neurosciences

Molecular Dynamics Simulation for All

Scott A. Hollingsworth et al.

NEURON (2018)

Article Multidisciplinary Sciences

Uranium (VI) detection in groundwater using a gold nanoparticle/paper-based lateral flow device

Daniel Quesada-Gonzalez et al.

SCIENTIFIC REPORTS (2018)

Review Chemistry, Multidisciplinary

Metal enhanced fluorescence biosensing: from ultra-violet towards second near-infrared window

Sarah Madeline Fothergill et al.

NANOSCALE (2018)

Review Chemistry, Analytical

Smart Polymers in Micro and Nano Sensory Devices

Jose Antonio Reglero Ruiz et al.

CHEMOSENSORS (2018)

Article Biochemical Research Methods

An aptamer folding-based sensory platform decorated with nanoparticles for simple cocaine testing

Emine Guler et al.

DRUG TESTING AND ANALYSIS (2017)

Review Biotechnology & Applied Microbiology

Aptamers as targeted therapeutics: current potential and challenges

Jiehua Zhou et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Chemistry, Multidisciplinary

Analysis of aptamer discovery and technology

Matthew R. Dunn et al.

Nature Reviews Chemistry (2017)

Article Multidisciplinary Sciences

Isolation, Detection, and Quantification of Cancer Biomarkers in HPV-Associated Malignancies

Hakan Inan et al.

SCIENTIFIC REPORTS (2017)

Review Chemistry, Multidisciplinary

Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges

Zdenek Farka et al.

CHEMICAL REVIEWS (2017)

Article Chemistry, Medicinal

DNA-duplex linker for AFM-SELEX of DNA aptamer against human serum albumin

Musashi Takenaka et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Review Chemistry, Multidisciplinary

Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery

Heidi R. Culver et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

Article Biochemical Research Methods

Design and characterization of electrochemical dopamine-aptamer as convenient and integrated sensing platform

Azadeh Azadbakht et al.

ANALYTICAL BIOCHEMISTRY (2016)

Article Biochemical Research Methods

A novel impedimetric aptasensor, based on functionalized carbon nanotubes and prussian blue as labels

Azadeh Azadbakht et al.

ANALYTICAL BIOCHEMISTRY (2016)

Review Chemistry, Analytical

Electrochemical aptamer-based biosensors as potential tools for clinical diagnostics

Marta Jarczewska et al.

ANALYTICAL METHODS (2016)

Article Biophysics

A reliable aptamer array prepared by repeating inkjet-spotting toward on-site measurement

Suzuyo Inoue et al.

BIOSENSORS & BIOELECTRONICS (2016)

Review Biotechnology & Applied Microbiology

Aptamer-based 'point-of-care testing'

Subash C. B. Gopinath et al.

BIOTECHNOLOGY ADVANCES (2016)

Review Biotechnology & Applied Microbiology

Point-of-care diagnostics for niche applications

Brian M. Cummins et al.

BIOTECHNOLOGY ADVANCES (2016)

Review Biotechnology & Applied Microbiology

Portable microfluidic and smartphone-based devices for monitoring of cardiovascular diseases at the point of care

Jie Hu et al.

BIOTECHNOLOGY ADVANCES (2016)

Review Chemistry, Multidisciplinary

Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

Hong-Min Meng et al.

CHEMICAL SOCIETY REVIEWS (2016)

Review Pathology

Advances in addressing technical challenges of point-of-care diagnostics in resource-limited settings

ShuQi Wang et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2016)

Review Biochemical Research Methods

Paper-based sensors and assays: a success of the engineering design and the convergence of knowledge areas

Adaris M. Lopez-Marzo et al.

LAB ON A CHIP (2016)

Article Medicine, General & Internal

Belatacept and Long-Term Outcomes in Kidney Transplantation

Flavio Vincenti et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Biotechnology & Applied Microbiology

Flexible Substrate-Based Devices for Point-of-Care Diagnostics

ShuQi Wang et al.

TRENDS IN BIOTECHNOLOGY (2016)

Review Biochemical Research Methods

Advances in mass spectrometry-based clinical biomarker discovery

Christopher A. Crutchfield et al.

CLINICAL PROTEOMICS (2016)

Review Chemistry, Analytical

Plasmon-enhanced optical sensors: a review

Ming Li et al.

ANALYST (2015)

Review Medicine, Research & Experimental

Emerging Technologies for Point-of-Care Management of HIV Infection

Hadi Shafiee et al.

ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

Review Biophysics

Aptamers as a replacement for antibodies in enzyme-linked immunosorbent assay

Saw Yi Toh et al.

BIOSENSORS & BIOELECTRONICS (2015)

Review Biophysics

Replacing antibodies with aptamers in lateral flow immunoassay

Ailiang Chen et al.

BIOSENSORS & BIOELECTRONICS (2015)

Review Biotechnology & Applied Microbiology

Recent advances in micro/nanotechnologies for global control of hepatitis B infection

U. Hakan Yildiz et al.

BIOTECHNOLOGY ADVANCES (2015)

Article Engineering, Electrical & Electronic

Advances in Nanotechnology and Microfluidics for Human Papillomavirus Diagnostics

Savas Tasoglu et al.

PROCEEDINGS OF THE IEEE (2015)

Article Multidisciplinary Sciences

Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics

Fatih Inci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Paper and Flexible Substrates as Materials for Biosensing Platforms to Detect Multiple Biotargets

Hadi Shafiee et al.

SCIENTIFIC REPORTS (2015)

Article Multidisciplinary Sciences

Portable Microfluidic Integrated Plasmonic Platform for Pathogen Detection

Onur Tokel et al.

SCIENTIFIC REPORTS (2015)

Review Chemistry, Multidisciplinary

Upconversion Luminescent Materials: Advances and Applications

Jing Zhou et al.

CHEMICAL REVIEWS (2015)

Article Chemistry, Analytical

Aptamer Biosensor for Selective and Rapid Determination of Insulin

Seyed Mohammad Taghdisi et al.

ANALYTICAL LETTERS (2015)

Article Biochemistry & Molecular Biology

Sensitive Electrochemical Aptasensor for Thrombin Detection Based on Graphene Served as Platform and Graphene Oxide as Enhancer

Chun He et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2014)

Review Chemistry, Multidisciplinary

Advances in Plasmonic Technologies for Point of Care Applications

Onur Tokel et al.

CHEMICAL REVIEWS (2014)

Review Chemistry, Multidisciplinary

Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

Guanying Chen et al.

CHEMICAL REVIEWS (2014)

Article Engineering, Biomedical

Developing Trends in Aptamer-Based Biosensor Devices and Their Applications

Scott MacKay et al.

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS (2014)

Article Chemistry, Multidisciplinary

Nanoplasmonic Quantitative Detection of Intact Viruses from Unprocessed Whole Blood

Fatih Inci et al.

ACS NANO (2013)

Review Biochemical Research Methods

Lateral-flow immunoassays for mycotoxins and phycotoxins: a review

Laura Anfossi et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2013)

Review Biotechnology & Applied Microbiology

Point-of-care assays for tuberculosis: Role of nanotechnology/microfluidics

ShuQi Wang et al.

BIOTECHNOLOGY ADVANCES (2013)

Article Chemistry, Analytical

Nanoporous anodic aluminum oxide for chemical sensing and biosensors

Abel Santos et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2013)

Article Biophysics

A rapid DNA biosensor for the molecular diagnosis of infectious disease

AngLim Chua et al.

BIOSENSORS & BIOELECTRONICS (2011)

Review Electrochemistry

Electrochemical Aptamer-Based Biosensors: Recent Advances and Perspectives

Abd-Elgawad Radi

INTERNATIONAL JOURNAL OF ELECTROCHEMISTRY (2011)

Article Microbiology

Role of Rapid Immunochromatographic Antigen Testing in Diagnosis of Influenza A Virus 2009 H1N1 Infection

David F. Welch et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2010)

Review Chemistry, Multidisciplinary

LSPR-based nanobiosensors

Borja Sepulveda et al.

NANO TODAY (2009)

Editorial Material Biochemical Research Methods

Aptamers and their applications

Marco Mascini

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2008)

Review Chemistry, Analytical

Protein detection with aptamer biosensors

Beate Strehlitz et al.

SENSORS (2008)

Article Biology

Aptamer-based therapeutics and their potential in radiopharmaceutical design

Catia S. M. Ferreira et al.

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY (2007)

Article Biochemical Research Methods

Sensitivity enhancement of surface plasmon resonance biosensing of small molecules

JS Mitchell et al.

ANALYTICAL BIOCHEMISTRY (2005)

Review Microbiology

Diagnostics for the developing world

D Mabey et al.

NATURE REVIEWS MICROBIOLOGY (2004)

Review Biotechnology & Applied Microbiology

FRET imaging

EA Jares-Erijman et al.

NATURE BIOTECHNOLOGY (2003)