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Liping Huang et al.
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Ana C. H. Castro et al.
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Jiawei Gong et al.
Summary: In this study, a novel solid-state electrochemiluminescence (ECL) platform was developed for rapid and ultra-sensitive detection of SARS-CoV-2 antibody. The platform utilizes bipolar silica nanochannel array to stably confine the ECL probe and achieve reliable detection of SARS-CoV-2 IgG.
BIOSENSORS & BIOELECTRONICS
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Beatriz A. Braz et al.
Summary: This study reports the development of a simplified electrochemical immunosensor using a graphene-binding peptide for detecting SARS-CoV-2 antibodies. The sensor showed good linear regression and detection limit, and demonstrated high selectivity in serum samples, making it promising for diagnosing other infections with high antibody titers.
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Merryn Voysey et al.
Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.
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Jianxi Qu et al.
Summary: A microflow cytometry-based agglutination immunoassay (MCIA) was proposed for on-site antibody or antigen detection, with CRP detection chosen as a model assay to demonstrate the detection principle. The system showed a linear relationship between the average transit time of aggregates and CRP concentrations, with a high R-squared value and a low detection limit.
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Abdulhadee Yakoh et al.
Summary: A specific and sensitive immunosensor has been developed for the detection of immunoglobulins produced against SARS-CoV-2, targeting SARS-CoV-2 antibodies without the need for specific antibodies. This sensor has shown effective results in real clinical sera and has the potential for expanded use in antigen detection, presenting new possibilities for diagnosing COVID-19.
BIOSENSORS & BIOELECTRONICS
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Summary: This study designed a robust electrochemical biosensor for selective and quantitative analysis of SARS-CoV-2-specific viral antibodies, demonstrating high sensitivity and specificity in experiments without the need for labeling, making it a sensitive immunological diagnostic method for SARS-CoV-2 antibodies.
MICROCHEMICAL JOURNAL
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Hend S. Magar et al.
Summary: Electrochemical impedance spectroscopy (EIS) is a powerful technique for analyzing interfacial properties related to bio-recognition events at the electrode surface, with applications in biomedical diagnosis and environmental monitoring. The use of nanomaterials enhances the analytical features of impedimetric biosensors, promoting faster electron transfer and improving sensor reliability and accuracy.
Review
Chemistry, Analytical
Varnakavi Naresh et al.
Summary: Biosensors are receptor-transducer devices that convert biological responses into electrical signals, which have gained significant attention from researchers and scientists in the past decade due to their wide applications in various fields. The main challenges in biosensor development include efficient capture of biorecognition signals, enhancing transducer performance, and miniaturization of biosensing devices, which can be addressed through the integration of sensing technology with nanomaterials.
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Adriana Martinez-Cuazitl et al.
Summary: This study utilized ATR-FTIR spectroscopy to analyze salivary samples from COVID-19 patients and healthy individuals, establishing specific salivary vibrational modes and successfully differentiating between the two groups using an MLRM model. The COVID-19 patients exhibited symptoms such as low SaO(2), cough, dyspnea, headache, and fever, with elevated levels of C-reactive protein, lactate dehydrogenase, fibrinogen, d-dimer, and ferritin in laboratory tests. Additionally, changes in amide I and immunoglobulin regions were observed in the FTIR spectra analysis, contributing to the discrimination between COVID-19 patients and healthy individuals.
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William T. Harvey et al.
Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.
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Jie Li et al.
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Yu Min Kang et al.
Summary: The study found that both ChAdOx1 and BNT162b2 vaccines induced antibody responses, with higher levels observed in the BNT162b2 group. In the ChAdOx1 vaccine group, women had higher levels of neutralizing antibodies compared to men.
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Summary: Surface plasmon resonance (SPR) is an effective strategy for detecting antibodies in COVID-19 patients, with high sensitivity and specificity. The study successfully demonstrated the detection of antibody responses to SARS-CoV-2 using SPR, showing high sensitivity and specificity.
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