Cigarette Smoke-Induced Gastric Cancer Cell Exosomes Affected the Fate of Surrounding Normal Cells via the Circ0000670/Wnt/beta-Catenin Axis

Article Cell Biology

Linc00852 from cisplatin-resistant gastric cancer cell-derived exosomes regulates COMMD7 to promote cisplatin resistance of recipient cells through microRNA-514a-5p

Shuguang Cao et al.

Summary: This study found that Linc00852 regulates COMMD7 expression through miR-514a-5p to promote drug resistance of gastric cancer cells. Additionally, Linc00852 in exosomes can enhance the resistance of gastric cancer cells to cisplatin.

CELL BIOLOGY AND TOXICOLOGY (2023)

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Article Cell Biology

CircRNA_0026344 via miR-21 is involved in cigarette smoke-induced autophagy and apoptosis of alveolar epithelial cells in emphysema

Jing Zhao et al.

Summary: Cigarette smoke is a main risk factor for emphysema, and a recent study found that circular RNA can regulate cigarette smoke-induced autophagy and apoptosis in alveolar epithelial cells by inhibiting miRNA. This discovery provides new insights and information for the diagnosis and treatment of emphysema.

CELL BIOLOGY AND TOXICOLOGY (2023)

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Article Oncology

Gastric cancer exosomes contribute to the field cancerization of gastric epithelial cells surrounding gastric cancer

Jung Hwan Yoon et al.

Summary: This study found that exosomes derived from gastric cancer cells can affect the fate of surrounding gastric epithelial cells. Gastric cancer exosomes promote cell survival and proliferation while inhibiting cellular senescence and apoptosis. The exosomes also regulate the expression of telomere-related genes, heat-shock genes, and hedgehog genes.

GASTRIC CANCER (2022)

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Article Biochemistry & Molecular Biology

METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis

Hui-Ning Fan et al.

Summary: Our study reveals that METTL14-mediated m(6)A modification of circORC5 suppresses the progression of gastric cancer by regulating the miR-30c-2-3p/AKT1S1 axis.

MOLECULAR CANCER (2022)

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Article Biochemistry & Molecular Biology

Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer

Souvick Roy et al.

Summary: This study developed a non-invasive liquid biopsy method for early detection of gastric cancer by using circular RNAs (circRNAs) as biomarkers. The researchers identified a panel of 8 circRNAs that could reliably distinguish gastric cancer patients from non-disease controls, even in early-stage patients. The decreased expression of circRNAs in serum samples suggested their tumor specificity.

MOLECULAR CANCER (2022)

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Article Pharmacology & Pharmacy

Editor: Lawrence Lash Keywords: Cigarette smoke Epithelial-mesenchymal transition Prostate Exosomes Circ_0001359 Collagen deposition

Jinglou Chen et al.

Summary: Cigarette smoke exposure promotes prostatic fibrosis. Circ_0001359 derived from CS-WPMY-1-exo contributes to prostatic fibrosis by stimulating epithelial cells phenotypes changes and collagen deposition.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2022)

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Article Biotechnology & Applied Microbiology

microRNA-20b-5p overexpression combing Pembrolizumab potentiates cancer cells to radiation therapy via repressing programmed death-ligand 1

Kexin Jiang et al.

Summary: This study investigated the role and mechanism of miR-20b-5p in Pembrolizumab's effect on the radiosensitivity of tumor cells. The results showed that overexpression of miR-20b-5p combined with Pembrolizumab can enhance the sensitivity of tumor cells to radiation by targeting PD-L1 and inactivating PD-L1/PD1.

BIOENGINEERED (2022)

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Article Biotechnology & Applied Microbiology

Exosomes-derived miR-154-5p attenuates esophageal squamous cell carcinoma progression and angiogenesis by targeting kinesin family member 14

Yuwei Shou et al.

Summary: This study identified that exosomes-derived miR-154-5p attenuates the progression and angiogenesis of ESCC by targeting KIF14, providing a novel approach for the diagnosis and treatment of ESCC.

BIOENGINEERED (2022)

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Article Biotechnology & Applied Microbiology

LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer

Jia-Hong Liang et al.

Summary: LncRNA RSU1P2 plays an important role in liver cancer by modulating tumorigenesis and cancer stem cell-like properties through the let-7a/Tex10 pathway.

BIOENGINEERED (2022)

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Article Oncology

Association of Antiparietal Cell and Anti-Intrinsic Factor Antibodies With Risk of Gastric Cancer

Minkyo Song et al.

Summary: The cohort study showed that autoantibody positivity may indicate subclinical autoimmune gastritis in younger women, particularly in H pylori-seronegative individuals. The findings among young females and corpus subsite align with increasing cancer incidence trends for these groups, suggesting autoimmune gastritis may be replacing H pylori as the driving factor.

JAMA ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

In vitro exosomal transfer of Nrf2 led to the oxaliplatin resistance in human colorectal cancer LS174T cells

Mostafa Mostafazadeh et al.

Summary: This study evaluated the role of exosomal Nrf2 in chemotherapy resistance of colon cancer cells. The results showed that Nrf2 in exosomes can promote oxaliplatin resistance by upregulating P-gp.

CELL BIOCHEMISTRY AND FUNCTION (2022)

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Article Cell Biology

HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis

Youwen Tan et al.

Summary: This study reveals that the secreted exosomes from human umbilical cord mesenchymal stem cells can alleviate liver fibrosis by promoting ferroptosis in hepatic stellate cells. The mechanism involves the promotion of ferroptosis-like cell death, ROS formation, mitochondrial dysfunction, Fe-2(+) release, and lipid peroxidation, as well as the suppression of xCT-driven GPX4 expression by MSC-ex derived BECN1. This study highlights the potential of MSC-ex as a therapeutic strategy for liver fibrosis.

CELL DEATH & DISEASE (2022)

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Article Cell Biology

CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA- and RBP-dependent manner

Shengkui Qiu et al.

Summary: This study identified circTHBS1 as an oncogenic circRNA that enhances the malignancy of gastric cancer by elevating the expression of INHBA. It provides new insights and a feasible target for the diagnosis and treatment of gastric cancer.

CELL DEATH & DISEASE (2022)

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Article Respiratory System

Exosomes derived from adipose-derived stem cells alleviate cigarette smoke-induced lung inflammation and injury by inhibiting alveolar macrophages pyroptosis

Zhixing Zhu et al.

Summary: The study demonstrates that ADSCs-Exo can effectively alleviate cigarette smoke-induced lung inflammation and injury by inhibiting AMs pyroptosis. This suggests that ADSCs-Exo may be a promising cell-free therapeutic candidate for cigarette smoke-induced lung inflammation and injury.

RESPIRATORY RESEARCH (2022)

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Article Gastroenterology & Hepatology

Mist1+gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice

Henrik Nienhuser et al.

Summary: The study revealed that gastric Mist1+ isthmus cells are activated in response to injury and inflammation, playing a crucial role in the regeneration of gastric glands through the Wnt5a pathway.

GUT (2021)

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Article Biochemistry & Molecular Biology

miRNAomics analysis reveals the promoting effects of cigarette smoke extract-treated Beas-2B-derived exosomes on macrophage polarization

Zhen Chen et al.

Summary: Cigarette smoke-induced inflammation in the lungs, leading to conditions like COPD, is influenced by macrophage polarization and cross-talk between alveolar macrophages and lung epithelial cells via exosomes and miRNAs. This study identified differentially expressed exosomal miRNAs and their target genes involved in regulating macrophage polarization pathways. Furthermore, miR-21-3p and miR-27b-3p were found to play critical roles in promoting macrophage polarization in response to cigarette smoke exposure.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Gastroenterology & Hepatology

Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis

Li Yu et al.

Summary: The study revealed that circNEK9 plays a promoting role in GC, accelerating the proliferation, migration, and invasion of GC cells through the miR-409-3p/MAP7 axis. Exosome-mediated transfer of circNEK9 promoted the motility of recipient GC cells.

DIGESTIVE DISEASES AND SCIENCES (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Cell Biology

Exosomes derived from autologous dermal fibroblasts promote diabetic cutaneous wound healing through the Akt/β-catenin pathway

Xinye Han et al.

Summary: DF-Ex can reverse the damage caused by high glucose in HUVECs and accelerate diabetic cutaneous wound healing; DF-Ex exerts its effects by activating the Akt/beta-catenin pathway; This research provides a new treatment strategy for diabetic cutaneous wound healing.

CELL CYCLE (2021)

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Article Cell Biology

Circular RNA ITCH suppresses metastasis of gastric cancer via regulating miR-199a-5p/Klotho axis

Yan Wang et al.

Summary: In this study, circ-ITCH was found to suppress GC metastasis by acting as a sponge for miR-199a-5p and increasing Klotho expression, providing potential biomarkers and targets for the diagnosis and therapy of GC.

CELL CYCLE (2021)

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Article Gastroenterology & Hepatology

Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer

Kazuhiro Togasaki et al.

Summary: In diffuse gastric cancer, signet-ring cell carcinoma (SRCC) and poorly cohesive carcinoma not otherwise specified (PCC-NOS) were found to be clonally identical, with their morphology regulated by external Wnt and R-spondin expression. The study results decoded how genetic mutations and the tumor microenvironment shape pathohistologic and biologic phenotypes in human diffuse gastric cancers.

GASTROENTEROLOGY (2021)

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Article Biochemistry & Molecular Biology

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression

Yin Peng et al.

Summary: The circRNA circAXIN1 was found to be highly expressed in gastric cancer tissues compared to normal gastric tissues, and encodes a novel protein named AXIN1-295aa. AXIN1-295aa functions as an oncogenic protein, activating the Wnt signaling pathway to promote gastric cancer tumorigenesis and progression, suggesting a potential therapeutic target.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

Lymph node metastasis-derived gastric cancer cells educate bone marrow-derived mesenchymal stem cells via YAP signaling activation by exosomal Wnt5a

Mei Wang et al.

Summary: The study found that LNM-GCs specifically educated BM-MSCs via secretory exosomes, with exosomal Wnt5a identified as a key protein. Exosomes enriched with Wnt5a induced YAP dephosphorylation in BM-MSCs, while those lacking Wnt5a had the opposite effect. Inhibition of the YAP signaling pathway blocked the reprogramming of BM-MSCs by LNM-GC exosomes and serum exosomes.

ONCOGENE (2021)

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Article Biotechnology & Applied Microbiology

Serum hsa_circ_0087776 as a new oncologic marker for the joint diagnosis of multiple myeloma

Xingxing Gong et al.

Summary: This study found that hsa_circ_0087776 can be used as a new oncology marker for the combined diagnosis of multiple myeloma. Its expression is significantly lower in the serum and cells of MM patients, and when combined with other indicators, it improves diagnostic sensitivity.

BIOENGINEERED (2021)

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Review Oncology

Exosomes and Exosomal circRNAs: The Rising Stars in the Progression, Diagnosis and Prognosis of Gastric Cancer

Ling Lu et al.

Summary: Exosomal circRNAs, as potential diagnosis and prognosis biomarkers, play important roles in gastric cancer and have clinical significance.

CANCER MANAGEMENT AND RESEARCH (2021)

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Review Biochemistry & Molecular Biology

The role and application of small extracellular vesicles in gastric cancer

Hao Wu et al.

Summary: sEVs, especially exosomes, play crucial roles in GC by influencing the tumor microenvironment, cell-to-cell communication, and immunotherapeutic efficacy, showing potential clinical applications in the future.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

Gastric cancer derived exosomes mediate the delivery of circRNA to promote angiogenesis by targeting miR-29a/VEGF axis in endothelial cells

Shuang Li et al.

Summary: As a sponge of miR-29a, circ29 plays a critical role in the initiation and development of gastric cancer by regulating the VEGF pathway, affecting cell proliferation, migration, and tube formation. It may serve as a potential target for the treatment of GC.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Cell Biology

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming

Samantha M. Morrissey et al.

Summary: The study reveals that tumor-derived exosomes can polarize macrophages towards an immunosuppressive phenotype through NF-kB and glycolytic reprogramming, and are associated with lactate, GLUT-1, and YKT6 factors, further promoting tumor metastasis.

CELL METABOLISM (2021)

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Review Cell Biology

Exosomes as mediators of intercellular crosstalk in metabolism

Roi Isaac et al.

Summary: Exosomes are nanoparticles secreted by all cell types, playing a role in intercellular and intraorgan communication by carrying biological signals such as proteins, lipids, and miRNAs. They have also been utilized as disease biomarkers.

CELL METABOLISM (2021)

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Article Immunology

Cigarette smoke extract-treated airway epithelial cells-derived exosomes promote M1 macrophage polarization in chronic obstructive pulmonary disease

Lijing Wang et al.

Summary: In this study, it was found that exosomes derived from cigarette smoke extract-treated mouse airway epithelial cells promoted M1 macrophage polarization by upregulating TREM-1 expression, thereby aggravating the development of COPD.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications

Xiao-Huan Tang et al.

Summary: Exosomes, a subpopulation of the tumour microenvironment (TME), are crucial for intercellular communication and are enriched with noncoding RNAs that play important roles in the tumorigenesis, progression, and drug resistance of gastric cancer (GC). Regulating exosomal ncRNAs levels could potentially serve as therapeutic targets for GC treatment.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability

Yu Zhang et al.

Summary: This study identified a new circRNA, circDIDO1, transcribed from the human DIDO1 gene, which functions as a tumor suppressor in gastric cancer by inhibiting cell proliferation, migration, and invasion. CircDIDO1 directly interacts with PARP1 and inhibits its activity, and promotes the degradation of PRDX2, leading to inactivation of downstream signaling pathways. CircDIDO1 may serve as a potential prognostic biomarker and therapeutic target for gastric cancer.

MOLECULAR CANCER (2021)

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Article Toxicology

CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis

Jun Bai et al.

Summary: The study revealed that circRNA_0026344 is involved in the aberrant epithelium-fibroblast cross-talk induced by cigarette smoke through regulation of miR-21 and Smad7 expression. These findings are important for the discovery of early biomarkers and therapeutic targets for smoking-induced pulmonary fibrosis.

TOXICOLOGY LETTERS (2021)

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Article Respiratory System

Circ-RBMS1 Knockdown Alleviates CSE-Induced Apoptosis, Inflammation and Oxidative Stress via Up-Regulating FBXO11 Through miR-197-3p in 16HBE Cells

Di Qiao et al.

Summary: The study revealed that circ-RBMS1 was highly expressed in COPD patients, with CSE inducing its expression in a dose-dependent manner. Knockdown of circ-RBMS1 attenuated apoptosis, inflammation, and oxidative stress induced by CSE in 16HBE cells through the miR-197-3p/FBXO11 axis.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2021)

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Article Medicine, Research & Experimental

Circular RNA circ-TNPO3 suppresses metastasis of GC by acting as a protein decoy for IGF2BP3 to regulate the expression of MYC and SNAIL

Ting Yu et al.

Summary: The study revealed that circ-TNPO3 plays a crucial inhibitory role in gastric cancer by regulating the MYC-SNAIL pathway to suppress proliferation and metastasis.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Oncology

Exosomal circRNA in Digestive System Tumors: The Main Player or Coadjuvants?

Haoying Wang et al.

Summary: Exosomal circRNAs play a significant role in the proliferation, invasion, migration, and drug resistance of digestive system tumors by sponging miRNAs. They may serve as biomarkers for disease diagnosis and therapeutic target identification in the future.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer

Jing Gao et al.

Summary: Exosomes play a crucial role in the formation of pre-metastatic niches in gastric cancer, facilitating tumor metastasis by establishing a supportive environment remotely. The cell components in pre-metastatic niches secrete exosomes that interact with each other, providing signals that promote tumor growth.

FRONTIERS IN ONCOLOGY (2021)

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Article Biotechnology & Applied Microbiology

The circular RNA circ0005654 interacts with specificity protein 1 via microRNA-363 sequestration to promote gastric cancer progression

Cui Yang et al.

Summary: Research suggests that circ0005654 promotes gastric cancer development and influences GC through interactions with the miR-363/sp1/myc/Wnt/beta-catenin pathway. Overexpression of circ0005654 is associated with poor prognosis in GC patients. Inhibition of circ0005654 significantly suppresses tumor activity in GC cells.

BIOENGINEERED (2021)

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Article Oncology

Clinicopathological Characteristics and Incidence of Gastric Cancer in Eastern India: A Retrospective Study

Paramita Ghosh et al.

Summary: The study revealed that gastric cancer incidence is associated with mid age male patients in eastern India, particularly with lymph node metastasis. The highest frequency of gastric cancer was found in the antrum (42.21%), and smoking was identified as a significant risk factor for the development of this type of cancer.

JOURNAL OF GASTROINTESTINAL CANCER (2021)

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Article Biochemistry & Molecular Biology