Evaluation of optimal monoenergetic images acquired by dual-energy CT in the diagnosis of T staging of thoracic esophageal cancer

ObjectivesThe purpose of our study was to objectively and subjectively assess optimal monoenergetic image (MEI (+)) characteristics from dual-energy CT (DECT) and the diagnostic performance for the T staging in patients with thoracic esophageal cancer (EC).MethodsIn this retrospective study, patients with histopathologically confirmed EC who underwent DECT from September 2019 to December 2020 were enrolled. One standard polyenergetic image (PEI) and five MEI (+) were reconstructed. Two readers independently assessed the lesion conspicuity subjectively and calculated the contrast-to-noise ratio (CNR) and the signal-to-noise ratio (SNR) of EC. Two readers independently assessed the T stage on the optimal MEI (+) and PEI subjectively. Multiple quantitative parameters were measured to assess the diagnostic performance to identify T1-2 from T3-4 in EC patients.ResultsThe study included 68 patients. Subjectively, primary tumor delineation received the highest ratings in MEI (+) (40 keV) of the venous phase. Objectively, MEI (+) images showed significantly higher SNR compared with PEI (p < 0.05), peaking at MEI (+) (40 keV) in the venous phase. CNR of tumor (MEI (+) (40 keV -80 keV)) was all significantly higher than PEI in arterial and venous phases (p < 0.05), peaking at MEI (+) (40 keV) in venous phases. The agreement between MEI (+) (40 keV) and pathologic T categories was 81.63% (40/49). Rho values in venous phases had excellent diagnostic efficiency for identifying T1-2 from T3-4 (AUC = 0.84).ConclusionsMEI (+) reconstructions at low keV in the venous phase improved the assessment of lesion conspicuity and also have great potential for preoperative assessment of T staging in patients with EC.

Automated summary

The purpose of this study was to assess the optimal characteristics of monoenergetic image (MEI (+)) from dual-energy CT (DECT) and its diagnostic performance for T staging in patients with thoracic esophageal cancer (EC). The results showed that MEI (+) at 40 keV in the venous phase had the best tumor delineation. The MEI (+) images had significantly higher signal-to-noise ratio (SNR) and tumor contrast-to-noise ratio (CNR) compared to the polyenergetic image (PEI). The agreement between MEI (+) (40 keV) and pathological T categories reached 81.63%.