The Oncosuppressive Properties of KCTD1: Its Role in Cell Growth and Mobility

Review Medicine, Research & Experimental

Therapeutic strategies targeting Wnt/β-catenin signaling for colorectal cancer

Yong Ji et al.

Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2022)

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Article Medicine, General & Internal

KCTD15 Is Overexpressed in her2+ Positive Breast Cancer Patients and Its Silencing Attenuates Proliferation in SKBR3 CELL LINE

Luigi Coppola et al.

Summary: Recent studies have shown that KCTD15 protein plays a significant role in breast cancer. This study evaluated the expression levels of KCTD15 in breast cancer cell lines and patients, and examined the effects of its silencing in a HER2+ cell model. The results revealed that KCTD15 is significantly overexpressed in Luminal A and Luminal B breast cancer patients, as well as in related cell lines, with the highest level of overexpression in HER2+ patients and the SKBR3 cell line model. Silencing KCTD15 using CRISPR/CAS9 technology attenuated the proliferation and cell cycle progression of SKBR3 cells, and also sensitized them to the cytotoxic agent doxorubicin. These findings suggest a potential role of KCTD15 in anti-HER2+ therapeutic strategies.

DIAGNOSTICS (2022)

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Review Biochemistry & Molecular Biology

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Jiaqi Liu et al.

Summary: This article provides a comprehensive review of the Wnt/β-catenin pathway, including its origin, composition, function, and clinical trials. It also discusses the challenges and opportunities for developing small-molecule compounds targeting this signaling pathway in disease treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Cell Biology

Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron

Alexander G. Marneros

Summary: The study reveals that deficiency of KCTD1 leads to dysregulation of magnesium and calcium homeostasis, resulting in hypomagnesemia and hypocalcemia, subsequently causing secondary hyperparathyroidism and progressive metabolic bone disease. This is driven by the reduced expression of key transport proteins in the kidneys, impacting urinary reabsorption of magnesium and calcium.

CELL REPORTS (2021)

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Review Cell Biology

The emerging role of the KCTD proteins in cancer

Annapaola Angrisani et al.

Summary: The KCTD protein family plays important roles in neurological disorders, obesity, and cancer, with many members still not fully characterized. Research suggests that KCTD members may be potential therapeutic targets or diagnostic/prognostic markers, highlighting the need for further investigation into their roles in tumorigenesis. These factors demonstrate the complexity and significance of KCTD proteins in cancer and other diseases.

CELL COMMUNICATION AND SIGNALING (2021)

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Article Biochemistry & Molecular Biology

AlphaFold-Predicted Structures of KCTD Proteins Unravel Previously Undetected Relationships among the Members of the Family

Luciana Esposito et al.

Summary: One of the key features of KCTD proteins is their involvement in various physiological and pathological processes. Despite the lack of structural data, the use of predicted three-dimensional models by AlphaFold has enabled researchers to gain insights into the relationships within the KCTD family. A novel pseudo-phylogenetic tree based on a common structurally similar domain in the C-terminal region has revealed previously undetected similarities among the KCTD proteins, providing a solid foundation for understanding their diverse functions.

BIOMOLECULES (2021)

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Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

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Review Cell Biology