Association of gamma-tocopherol serum concentrations and blood pressure among adults in the United States: a cross-sectional study

Backgroundhypertension is one of the major preventable risk factors for numerous diseases. The role of vitamin E in blood pressure (BP) has been controversial. We aimed to investigate the relationship between gamma-tocopherol serum concentration (GTSC) and BP MethodsData from 15,687 US adults from the National Health and Nutrition Examination Survey (NHANES) were analyzed. The correlations of GTSC with systolic BP (SBP), diastolic BP (DBP), and prevalence of hypertension were investigated by multivariate logistic regression models, generalized summation models, and fitted smoothing curves. Subgroup analyses were performed to investigate possible effect modifiers between them. ResultsWith each natural log increase in GTSC, SBP, and DBP increased by 1.28 mmHg (& beta; 1.28, 95% CI 0.71-1.84) and 1.15 mmHg (& beta; 1.15, 95% CI 0.72-1.57), respectively, both P for trend < 0.001; the prevalence of hypertension increased by 12% (OR 1.12, 95% CI 1.03-1.22), P for trend 0.008. In subgroup analysis, in drinkers, with each natural log increase in GTSC, SBP, and DBP increased by 1.77 mmHg (& beta; 1.77,95% CI 1.13-2.41) and 1.37 mmHg (& beta; 1.37,95% CI 0.9-1.85), respectively, whereas they were not correlated in non-drinkers. ConclusionGTSC was linearly and positively associated with SBP, DBP, and the prevalence of hypertension, and alcohol consumption may modify the relationship of GTSC with SBP and DBP.

Automated summary

This study analyzed data from 15,687 US adults and found a positive correlation between gamma-tocopherol serum concentration and systolic blood pressure, diastolic blood pressure, and the prevalence of hypertension. Additionally, alcohol consumption may modify the relationship between gamma-tocopherol concentration and blood pressure.