The latest global burden of liver cancer: A past and present threat

Article Gastroenterology & Hepatology

Global burden of primary liver cancer and its asso- ciation with underlying aetiologies, sociodemo- graphic status, and sex differences from 1990-2019: A DALY-based analysis of the Global Burden of Disease 2019 study

Sungchul Choi et al.

Summary: This study analyzed the temporal trends of liver cancer aetiologies and sociodemographic status in 204 countries and territories from 1990 to 2019. The study found that the crude numbers of liver cancer DALYs and deaths increased over the study period, but the age-standardized rates decreased. HBV remains the leading cause of liver cancer, followed by HCV, alcohol consumption, and NASH/NAFLD. The East Asia region had the highest age-standardized rates, while Central Asia showed an increase.

CLINICAL AND MOLECULAR HEPATOLOGY (2023)

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Article Gastroenterology & Hepatology

Hepatocellular carcinoma incidence is decreasing in Korea but increasing in the very elderly

Young Eun Chon et al.

Summary: This study analyzed the trends in hepatocellular carcinoma (HCC) incidence in South Korea over 10 years and predicted an increase in HCC incidence among elderly individuals in 2028.

CLINICAL AND MOLECULAR HEPATOLOGY (2023)

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Review Gastroenterology & Hepatology

Hepatocellular carcinoma surveillance in patients with non-alcoholic fatty liver disease

Karim Seif El Dahan et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing cause of hepatocellular carcinoma (HCC), and HCC surveillance is recommended for patients with cirrhosis from any cause and may be beneficial for high-risk subgroups with non-cirrhotic NAFLD. NAFLD-related HCC patients are more likely to have advanced stage cancer and poor outcomes due to suboptimal effectiveness of surveillance programs. This review summarizes current HCC surveillance guidelines, discusses challenges specific to NAFLD, and examines the effectiveness of current surveillance tools while suggesting future approaches to improve adherence.

CLINICAL AND MOLECULAR HEPATOLOGY (2023)

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Review Gastroenterology & Hepatology

Toward a complete cure for chronic hepatitis B: Novel therapeutic targets for hepatitis B virus

Sun Woong Kim et al.

Summary: Hepatitis B virus (HBV) infection is a serious global public health problem, and there is currently no complete cure. The focus of recent research has been on achieving a functional cure for HBV through combination therapies and immunomodulators. New therapeutic approaches and clinical trials are being conducted to find a long-lasting cure for HBV infection.

CLINICAL AND MOLECULAR HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Global burden of primary liver cancer in 2020 and predictions to 2040

Harriet Rumgay et al.

Summary: The burden of liver cancer varies across the world, and it is a major cause of death in many countries. The number of liver cancer cases and deaths is predicted to increase, with a significant rise expected by 2040.

JOURNAL OF HEPATOLOGY (2022)

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Editorial Material Gastroenterology & Hepatology