4.6 Review

The role of integrin family in bone metabolism and tumor bone metastasis

Related references

Note: Only part of the references are listed.
Article Cell Biology

Negative pressure wound therapy improves bone regeneration by promoting osteogenic differentiation via the AMPK-ULK1-autophagy axis

Sheng Zhang et al.

Summary: The study reveals that negative pressure wound therapy promotes bone regeneration and induces osteoblast differentiation in vitro. Negative pressure induces osteogenesis through activating large autophagy by AMPK-ULK1 signaling, which plays a crucial role in bone regeneration.

AUTOPHAGY (2022)

Article Endocrinology & Metabolism

Galectin-3 Enhances Osteogenic Differentiation of Precursor Cells From Patients With Diffuse Idiopathic Skeletal Hyperostosis via Wnt/beta-Catenin Signaling

Liang Xu et al.

Summary: This study found that DISH patients' BMSCs have stronger osteogenic differentiation abilities compared to the normal control group. The increased secretion of Galectin-3 in DISH-BMSCs promotes ectopic bone formation and is involved through enhancing the Wnt/β-catenin signaling pathway.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Enhancing 223Ra Treatment Efficacy by Anti-β1 Integrin Targeting

Claudia Paindelli et al.

Summary: In this study, targeting beta 1 integrin (beta 1I) was shown to significantly improve the outcome of Ra-223 treatment for bone metastatic prostate cancer (PCa), particularly in tumors with high beta 1I expression.

JOURNAL OF NUCLEAR MEDICINE (2022)

Article Endocrinology & Metabolism

Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression

Huai-Ching Tai et al.

Summary: Melatonin has been found to inhibit the migratory and invasive abilities of osteoblastic prostate cancer cells by targeting kinases and transcriptional activity, suggesting its potential as a therapeutic option for treating osteoblastic bone lesions in prostate cancer.

JOURNAL OF PINEAL RESEARCH (2022)

Article Cell Biology

Tetraspanin 7 regulates osteoclast function through association with the RANK/αvβ3 integrin complex

Minhee Kim et al.

Summary: The study revealed that TSPAN7 plays a crucial role in regulating the bone-resorbing function of osteoclasts by modulating actin ring formation. Deletion of Tm4sf2 led to significant defects in integrin-mediated actin ring formation, resulting in decreased bone resorption. The findings suggest that TSPAN7 acts as a novel modulator in osteoclasts.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

Article Multidisciplinary Sciences

EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation

Lin Zhang et al.

Summary: This study reveals a new mechanism of bone metastasis in breast cancer, demonstrating that EZH2 promotes metastasis through regulating TGF beta signaling, providing potential targets for therapeutic intervention.

NATURE COMMUNICATIONS (2022)

Article Oncology

ICAM1 promotes bone metastasis via integrin-mediated TGF-β/EMT signaling in triple-negative breast cancer

Mingcang Chen et al.

Summary: Bone-related events caused by breast cancer bone metastasis significantly impact patients' survival and quality of life. ICAM1, highly expressed in TNBC, correlates with prognosis in TNBC patients. ICAM1 interacts with integrins to activate signaling pathways, enhancing cell invasiveness, providing a rationale for ICAM1-targeted therapy.

CANCER SCIENCE (2022)

Article Medicine, Research & Experimental

IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer

Yunfei He et al.

Summary: This study revealed the role of IL-20RB in promoting bone metastasis of lung cancer. IL-20RB facilitated the growth of lung cancer cells in the bone by activating JAK1/STAT3 signaling. Blocking IL-20RB significantly suppressed the bone metastasis of lung cancer.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Review Cell & Tissue Engineering

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Simona Bolamperti et al.

Summary: Bone remodeling is a continuous cellular process that replaces old and damaged bone with new bone on the same surface. Recent research has shown that all bone cells participate in bone remodeling by interacting with their progenitors, other cells, and bone matrix constituents at different differentiation stages.

BONE RESEARCH (2022)

Article Biochemistry & Molecular Biology

CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin α5 expression

Dandan Zhang et al.

Summary: ADSCs' osteogenic differentiation is regulated by circRNA-vgll3, which promotes ADSC osteogenesis through the circRNA-vgll3/miR-326-5p/Integrin Alpha 5 pathway. The study demonstrates that circRNA-vgll3 can enhance new bone formation, making it a potential effective therapeutic target in bone regenerative medicine.

CELL DEATH AND DIFFERENTIATION (2021)

Article Oncology

Conditional knockdown of integrin beta-3 reveals its involvement in osteolytic and soft tissue lesions of breast cancer skeletal metastasis

Marineta Kovacheva et al.

Summary: Integrin beta 3 (ITGB3) plays a significant role in breast cancer skeletal metastasis through gene expression modulation, and its inhibition leads to decreased cellular proliferation and migration, as well as reductions in soft tissue and osteolytic lesions. Changes in ITGB3 levels in exosomes may be associated with breast cancer skeletal metastasis.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

Article Cell Biology

Integrin α11β1 is a receptor for collagen XIII

Jarkko Koivunen et al.

Summary: Collagen XIII is a transmembrane collagen expressed in mesenchymal tissues, and it interacts with integrin alpha 11 beta 1 to regulate bone homeostasis. The study showed that integrin alpha 11 beta 1 acts as a receptor for collagen XIII, mediating cell adhesion to specific collagenous motifs, and plays a role in maintaining bone homeostasis.

CELL AND TISSUE RESEARCH (2021)

Article Biochemistry & Molecular Biology

Integrin alpha5 in human breast cancer is a mediator of bone metastasis and a therapeutic target for the treatment of osteolytic lesions

Francesco Pantano et al.

Summary: This study identified ITGA5 as a mediator of breast-to-bone metastasis, with high expression correlating with poor bone metastasis-free survival. Silencing ITGA5 impaired tumor cell functions and bone metastasis, while inhibition with M200 showed similar effects.

ONCOGENE (2021)

Article Oncology

LncRNA SNHG16 promotes epithelial-mesenchymal transition by upregulating ITGA6 through miR-488 inhibition in osteosarcoma

Jie Bu et al.

Summary: The study revealed that SNHG16 promotes migration, invasion, and EMT of osteosarcoma cells by sponging miR-488 to release ITGA6. Overexpression of miR-488 and knockdown of SNHG16 can both suppress these malignant characteristics.

JOURNAL OF BONE ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

Michelle M. McDonald et al.

Summary: Research has shown that RANKL-stimulated osteoclasts can undergo fission to form osteomorphs, which are involved in the regulation of bone resorption and could be targeted for the treatment of skeletal diseases. Single-cell RNA sequencing revealed that osteomorphs are transcriptionally distinct from osteoclasts and macrophages, expressing non-canonical osteoclast genes associated with bone phenotypes when deleted in mice.
Article Medicine, Research & Experimental

Negative pressure wound therapy enhances bone regeneration compared with conventional therapy in a rabbit radius gap-healing model

Jin Zhu et al.

Summary: The study demonstrated that negative pressure wound therapy (NPWT) accelerates bone regeneration by enhancing MSC proliferation, osteoblastic differentiation, and promoting the expression of VEGF, BMP-2, and OPN. Compared to the control group, the NPWT group showed faster bone healing, higher X-ray scores, and increased percentage of positive vimentin-stained cells.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Genetics & Heredity

Long Noncoding RNA HOXA11-AS and Transcription Factor HOXB13 Modulate the Expression of Bone Metastasis-Related Genes in Prostate Cancer

Aya Misawa et al.

Summary: The highly expressed lncRNA HOXA11-AS in prostate cancer bone metastases cells promotes cell invasion and proliferation by regulating multiple signaling pathways and interacting with the transcription factor HOXB13. These two molecules together also control integrin signaling and bone metastasis-related CCL2/CCR2 in an autocrine and paracrine manner, ultimately promoting metastasis.

GENES (2021)

Article Oncology

Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases

Gregory C. Fox et al.

Summary: Breast cancer bone metastases are commonly incurable, with tumoral integrin β3 expression influenced by the bone microenvironment. High β3 expression is associated with poor outcomes in triple-negative breast cancer patients both before and after chemotherapy. Additionally, the study suggests mTORC1 inhibition combined with docetaxel can enhance the treatment efficacy in bone metastases.

MOLECULAR CANCER THERAPEUTICS (2021)

Article Biochemistry & Molecular Biology

Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis

Yuanyuan Guo et al.

Summary: Senile osteoporosis (SOP) is a typical aging-related disease characterized by a decrease in bone mass. Sirt3 plays a protective role against AGEs-induced BMSCs senescence and SOP by improving mitophagy, suggesting it as a potential therapeutic target for AGEs-associated SOP.

REDOX BIOLOGY (2021)

Review Biochemistry & Molecular Biology

The effects of biophysical stimulation on osteogenic differentiation and the mechanisms from ncRNAs

Liwei Mao et al.

Summary: This review summarizes the regulation of osteogenic differentiation by ncRNAs under biophysical stimulation, revealing the potential of exercise for the prevention of bone metabolism diseases.

CELL BIOCHEMISTRY AND FUNCTION (2021)

Article Biophysics

Composites made of polyorganophosphazene and carbon nanotube up-regulating osteogenic activity of BMSCs under electrical stimulation

Yiqian Huang et al.

Summary: Bone is an electrically responsive tissue, and electroactive materials such as biodegradable polyorganophosphazenes (POPPs) combined with electrical stimulation (ES) can enhance osteogenesis. Conductive composite films made of PAGP/CNT were found to promote faster proliferation and stronger osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) compared to PLLA/CNT films, suggesting new strategies for bone repair material design.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Biochemistry & Molecular Biology

Biphasic α2β1 Integrin Expression in Breast Cancer Metastasis to Bone

Milene N. O. Moritz et al.

Summary: The expression of α2β1 integrin is inversely correlated with bone metastatic potential in breast cancer. Overexpression of the α2 integrin subunit increases primary tumor growth and dissemination to bone, with no impact on tumor establishment and bone destruction.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell & Tissue Engineering

Intra-Articular Injection of miR-29a-3p of BMSCs Promotes Cartilage Self-Repairing and Alleviates Pain in the Rat Osteoarthritis

Qing Wang et al.

Summary: Intra-articular injection of bone marrow mesenchymal stem cells (BMSCs) transfected with miR-29a-3p inhibitor showed significant efficacy in preventing articular cartilage degeneration and relieving pain in osteoarthritis (OA). This treatment strategy has the potential to be a promising approach for the management of OA.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

Review Cell & Tissue Engineering

Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues

Lei Qin et al.

Summary: Mechanotransduction is a fundamental ability in living organisms that allows them to receive and respond to physical signals. Piezo proteins act as mechanically activated ion channels and play essential roles in mechanosensation and transduction in various organs and tissues. The Piezo family, especially Piezo1 and Piezo2, has been found to have predominant contributions in skeletal development and mechano-stimulated bone homeostasis.

BONE RESEARCH (2021)

Article Cell & Tissue Engineering

Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels

Manuel A. Riquelme et al.

Summary: Mechanical loading activates integrin alpha 5 and alpha V, leading to the opening of connexin 43 (Cx43) hemichannels (HCs) and release of bone anabolic factors. Inhibition of integrin alpha V affects HCs opening and disrupts PI3K/AKT signaling pathway, while integrin alpha 5 activation is dependent on PI3K/AKT activation. Dendritic alpha V is a more sensitive mechanosensor than alpha 5 in activating HCs at low fluid shear stress levels.

BONE RESEARCH (2021)

Article Cell & Tissue Engineering

Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling

Qinyu Ma et al.

Summary: The study identified the molecular profile of apoptotic bodies (ABs) derived from osteoclasts at different differentiation stages, showing marked differences in protein cargo and high similarity to parental cells. Functionally, pOC-ABs promoted endothelial progenitor cell differentiation and endothelial cell formation, while mOC-ABs induced osteogenic differentiation of mesenchymal stem cells and facilitated osteogenesis via RANKL reverse signaling, highlighting the important biological roles of ABs in coupling bone formation with resorption during bone remodeling.

BONE RESEARCH (2021)

Article Endocrinology & Metabolism

Roles of Olfactomedin 1 in Muscle and Bone Alterations Induced by Gravity Change in Mice

Takeshi Shimoide et al.

CALCIFIED TISSUE INTERNATIONAL (2020)

Review Immunology

Phagocytic Integrins: Activation and Signaling

Alvaro Torres-Gomez et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Tablysin-15 inhibits osteoclastogenesis and LPS-induced bone loss via attenuating the integrin αvβ3 pathway

Qingye Zeng et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

Article Endocrinology & Metabolism

CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity ofPTH

Gexin Zhao et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

Review Biochemistry & Molecular Biology

The M-CSF receptor in osteoclasts and beyond

Se Hwan Mun et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Article Cell & Tissue Engineering

Expression dynamics of integrin α2, α3, and αV upon osteogenic differentiation of human mesenchymal stem cells

Hyun Min Lee et al.

STEM CELL RESEARCH & THERAPY (2020)

Article Cell Biology

Ultrasound combined with SDF-1α chemotactic microbubbles promotes stem cell homing in an osteoarthritis model

Xi Xiang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Cell Biology

OPG Production Matters Where It Happened

Masayuki Tsukasaki et al.

CELL REPORTS (2020)

Article Cell Biology

BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis

Guo-dong Lu et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Cell Biology

Muscle-Derived Lumican Stimulates Bone Formation via Integrin α2β1 and the Downstream ERK Signal

Jin Young Lee et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Shear Stress Modulates Osteoblast Cell and Nucleus Morphology and Volume

Jianfeng Jin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

NF-κB signaling and integrin-β1 inhibition attenuates osteosarcoma metastasis via increased cell apoptosis

Rui Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Article Biochemistry & Molecular Biology

Alpha-5 Integrin Mediates Simvastatin-Induced Osteogenesis of Bone Marrow Mesenchymal Stem Cells

Pei-Lin Shao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Endocrinology & Metabolism

Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity

Gabriel M. Pagnotti et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Article Biochemistry & Molecular Biology

Mature osteoclast-derived apoptotic bodies promote osteogenic differentiation via RANKL-mediated reverse signaling

Qinyu Ma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Review Cell Biology

Integrins as biomechanical sensors of the microenvironment

Jenny Z. Kechagia et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Cell Biology

BK ablation attenuates osteoblast bone formation via integrin pathway

Yinhang Wang et al.

CELL DEATH & DISEASE (2019)

Review Cell Biology

Integrin trafficking in cells and tissues

Paulina Moreno-Layseca et al.

NATURE CELL BIOLOGY (2019)

Article Cell Biology

Integrin activation by talin, kindlin and mechanical forces

Zhiqi Sun et al.

NATURE CELL BIOLOGY (2019)

Review Cell & Tissue Engineering

Autophagy in bone homeostasis and the onset of osteoporosis

Xing Yin et al.

BONE RESEARCH (2019)

Article Cell & Tissue Engineering

Connexin 43 hemichannels protect bone loss during estrogen deficiency

Liang Ma et al.

BONE RESEARCH (2019)

Article Medicine, Research & Experimental

Integrin alpha5beta1 suppresses rBMSCs anoikis and promotes nitric oxide production

Hai-ying Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Biochemistry & Molecular Biology

MiR-127-3p Inhibits Cell Growth and Invasiveness by Targeting ITGA6 in Human Osteosarcoma

Dong Wang et al.

IUBMB LIFE (2018)

Article Biochemistry & Molecular Biology

A vitronectin-derived peptide reverses ovariectomy-induced bone loss via regulation of osteoblast and osteoclast differentiation

Seung-Ki Min et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Endocrinology & Metabolism

An O-Glycosylation of Fibronectin Mediates Hepatic Osteodystrophy Through α4β1 Integrin

Carla Sens et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2017)

Article Pharmacology & Pharmacy

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

Tzu-Hung Lin et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Fibronectins containing extradomain A or B enhance osteoblast differentiation via distinct integrins

Carla Sens et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Polymeric Delivery of siRNA against Integrin-β1 (CD29) to Reduce Attachment and Migration of Breast Cancer Cells

Daniel Nisakar Meenakshi Sundaram et al.

MACROMOLECULAR BIOSCIENCE (2017)

Review Cell & Tissue Engineering

Prostate Cancer Stem Cell Markers Drive Progression, Therapeutic Resistance, and Bone Metastasis

Koran S. Harris et al.

STEM CELLS INTERNATIONAL (2017)

Article Multidisciplinary Sciences

Effects of microgravity on osteoblast mitochondria: a proteomic and metabolomics profile

Anna Michaletti et al.

SCIENTIFIC REPORTS (2017)

Review Oncology

Bone metastasis: the importance of the neighbourhood

Peter I. Croucher et al.

NATURE REVIEWS CANCER (2016)

Article Biochemistry & Molecular Biology

Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells through down regulating the transcriptional co-activator TAZ

Zhe Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Hypergravity-induced enrichment of β1 integrin on the cell membranes of osteoblast-like cells via caveolae-dependent endocytosis

Shuai Zhou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Chondroitin Sulfate-E Binds to Both Osteoactivin and Integrin αVβ3 and Inhibits Osteoclast Differentiation

Tatsuya Miyazaki et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2015)

Article Immunology

Cooperation between IL-7 Receptor and Integrin α2β1 (CD49b) Drives Th17-Mediated Bone Loss

Mohammed-Amine El Azreq et al.

JOURNAL OF IMMUNOLOGY (2015)

Article Engineering, Biomedical

The role of integrin αvβ3 in osteocyte mechanotransduction

Matthew G. Haugh et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2015)

Article Multidisciplinary Sciences

Tumour exosome integrins determine organotropic metastasis

Ayuko Hoshino et al.

NATURE (2015)

Article Multidisciplinary Sciences

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Thomas R. Cox et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Integrin αv in the mechanical response of osteoblast lineage cells

Keiko Kaneko et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Engineering, Biomedical

The effect of type II collagen on MSC osteogenic differentiation and bone defect repair

Li-Hsuan Chiu et al.

BIOMATERIALS (2014)

Review Biochemistry & Molecular Biology

Senescence suppressors: their practical importance in replicative lifespan extension in stem cells

Eun Seong Hwang

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

Article Oncology

Targeting Integrin α6 Stimulates Curative-Type Bone Metastasis Lesions in a Xenograft Model

Terry H. Landowski et al.

MOLECULAR CANCER THERAPEUTICS (2014)

Article Endocrinology & Metabolism

Ameloblastin modulates osteoclastogenesis through the integrin/ERK pathway

Xuanyu Lu et al.

Review Physiology

Weight, muscle and bone loss during space flight: another perspective

T. P. Stein

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

D-pinitol Inhibits Prostate Cancer Metastasis through Inhibition of αVβ3 Integrin by Modulating FAK, c-Src and NF-κB Pathways

Tien-Huang Lin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Cell Biology

Effect of mechanical stretch on the proliferation and differentiation of BMSCs from ovariectomized rats

Yuqiong Wu et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2013)

Article Oncology

Targeting Constitutively Activated β1 Integrins Inhibits Prostate Cancer Metastasis

Yu-Chen Lee et al.

MOLECULAR CANCER RESEARCH (2013)

Review Endocrinology & Metabolism

Osteopetrosis: genetics, treatment and new insights into osteoclast function

Cristina Sobacchi et al.

NATURE REVIEWS ENDOCRINOLOGY (2013)

Article Multidisciplinary Sciences

Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require αVβ3 integrin

Mia M. Thi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell & Tissue Engineering

Comparison of Effects of Mechanical Stretching on Osteogenic Potential of ASCs and BMSCs

Brian E. Grottkau et al.

BONE RESEARCH (2013)

Article Endocrinology & Metabolism

DICAM inhibits osteoclast differentiation through attenuation of the integrin αVβ3 pathway

Youn-Kwan Jung et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2012)

Article Cell Biology

CCN3 increases BMP-4 expression and bone mineralization in osteoblasts

Tzu-Wei Tan et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

Down-regulation of β3-integrin inhibits bone metastasis of small cell lung cancer

Na Li et al.

MOLECULAR BIOLOGY REPORTS (2012)

Article Ophthalmology

Increased IL-7 Expression in Vogt-Koyanagi-Harada Disease

Yan Yang et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2012)

Article Endocrinology & Metabolism

WISP-1/CCN4 Regulates Osteogenesis by Enhancing BMP-2 Activity

Mitsuaki Ono et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2011)

Review Cell Biology

Regulation of membrane traffic by integrin signaling

Sara A. Wickstroem et al.

TRENDS IN CELL BIOLOGY (2011)

Review Oncology

Cancer to bone: a fatal attraction

Katherine N. Weilbaecher et al.

NATURE REVIEWS CANCER (2011)

Article Immunology

Alpha2beta1 integrin is the major collagen-binding integrin expressed on human Th17 cells

Marc Boisvert et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2010)

Article Neurosciences

Muscle-Derived Collagen XIII Regulates Maturation of the Skeletal Neuromuscular Junction

Anne Latvanlehto et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Biochemistry & Molecular Biology

Prostate cancer specific integrin αvβ3 modulates bone metastatic growth and tissue remodeling

N. P. McCabe et al.

ONCOGENE (2007)

Article Endocrinology & Metabolism

α9β1:: A novel osteoclast integrin that regulates osteoclast formation and function

Honowei Rao et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2006)

Article Endocrinology & Metabolism

Bone sialoprotein enhances migration of bone marrow stromal cells through matrices by bridging MMP-2 to αvβ3-integrin

Abdullah Karadag et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2006)

Article Biochemistry & Molecular Biology

M-CSF induces the stable interaction of cFms with alpha v beta(3) integrin in osteoclasts

Caryn L. Elsegood et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)

Article Endocrinology & Metabolism

Critical role of β3 integrin in experimental postmenopausal osteoporosis

HB Zhao et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2005)

Article Biochemistry & Molecular Biology

Modeled microgravity disrupts collagen I/integrin signaling during osteoblastic differentiation of human mesenchymal stem cells

VE Meyers et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2004)

Article Medicine, Research & Experimental

c-Fms and the αvβ3 integrin collaborate during osteoclast differentiation

R Faccio et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Review Multidisciplinary Sciences

Bone resorption by osteoclasts

SL Teitelbaum

SCIENCE (2000)