☆ 4.6 Review

Application of Convergent Science and Technology toward Ocular Disease Treatment

PHARMACEUTICALS (2023)

Related references

Note: Only part of the references are listed.

Review Ophthalmology

Biomaterials for dry eye disease treatment: Current overview and future perspectives

Minal Thacker et al.

Summary: Dry eye disease (DED) is a common health problem that affects millions of people. Current treatments include eye drops and anti-inflammatory agents, but they have limitations. This review discusses the potential of biomaterials such as nanosystems, hydrogels, and contact lenses as drug delivery systems for DED. Animal studies have shown promising results, but human trials are still needed. Long-term studies evaluating their safety and effectiveness would help in their transition to clinical use.

EXPERIMENTAL EYE RESEARCH (2023)

Add to Collection

Article Pharmacology & Pharmacy

Preparation and advanced characterization of highly drug-loaded, 3D printed orodispersible tablets containing fluconazole

Jolanta Pyteraf et al.

Summary: Due to the versatility of 3D printing in designing spatial structures, it can be applied to customized medicine production. However, further optimization and development of quality verification mechanisms are required for using this method in dosage form production. In this study, the authors prepared and characterized 3D printed oro-dispersible tablets containing fluconazole using FDM. The tablets showed good quality, precision, and met the required criteria for ODTs according to the European Pharmacopeia. The stability of the formulation was also confirmed.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

Add to Collection

Review Chemistry, Multidisciplinary

Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

Adaeze Linda Onugwu et al.

Summary: Diseases affecting the anterior segment of the eye are a major cause of vision impairment and blindness worldwide. Drug delivery to the eye through the topical ocular route is challenging due to structural and physiological constraints. Nanotechnology-based drug delivery systems have been investigated as effective alternatives to conventional ocular delivery systems for treating anterior segment diseases. This review discusses different nanotechnology-based delivery systems and their prospects in clinical use.

JOURNAL OF CONTROLLED RELEASE (2023)

Add to Collection

Article Materials Science, Multidisciplinary

Design principles of microneedles for drug delivery and sampling applications

Zhicheng Le et al.

Summary: Microneedles technology is an efficient and minimally invasive method for transdermal delivery of bioactive molecules, avoiding the use of hypodermic needles. It has expanded its applications to non-dermatological purposes and shown promise in biomolecular and cellular sampling for patient health monitoring and disease diagnosis. This review discusses the design principles of microneedles to overcome biological barriers and recent innovations in biomolecular and cellular sampling.

MATERIALS TODAY (2023)

Add to Collection

Article Chemistry, Multidisciplinary

In-situ nanomicelle forming microneedles of poly NIPAAm-b-poly glutamic acid for trans-scleral delivery of dexamethasone

Vahid Alimardani et al.

Summary: The researchers successfully synthesized a thermosensitive in-situ micelle-forming poly (N-isopropyl acrylamide)-b-poly (l-glutamic acid) copolymer, which was soluble in organic and aqueous solvents, enabling the preparation of microneedles containing hydrophilic drugs. The copolymer formed in-situ nanomicelles with sizes below 100 nm, allowing efficient encapsulation of dexamethasone (DEX). The findings suggest that this polymer can self-assemble into nanomicelles and significantly incorporate DEX as a hydrophobic drug, improving trans-scleral DEX permeation and providing a promising system for treating posterior ocular diseases.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2023)

Add to Collection

Article Pharmacology & Pharmacy

Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress

Ana R. Fernandes et al.

Summary: This study found that using cationic nanoemulsions to deliver triamcinolone acetonide (TA) can reduce the production of tumor necrosis factor alpha (TNF-alpha), which in turn decreases VEGF levels, indicating the potential use of these nanoemulsions for the treatment of age-related macular degeneration (AMD).

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Sustained latanoprost release from PEGylated solid lipid nanoparticle-laden soft contact lens to treat glaucoma

Hui Dang et al.

Summary: In this study, a novel drug-loaded contact lens was developed to increase drug loading capacity and sustain drug delivery. The drug-loaded contact lens showed improved performance and sustained release compared to conventional soaked lens and eye drop solution.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

A Rapid Corneal Healing Microneedle for Efficient Ocular Drug Delivery

Hui Shi et al.

Summary: This study presents a minimally invasive delivery system for treating fungal keratitis using a dissolving microneedle patch based on Poly(D,L-lactide) and hyaluronic acid. The microneedle patch shows excellent properties and can penetrate the cornea with no ocular irritation. In a rabbit model, the microneedle patch medication exhibits superior therapeutic effects compared to eye drops and is comparable to intrastromal injection, offering a cost-effective treatment solution.

SMALL (2022)

Add to Collection

Article Engineering, Biomedical

Self-Plugging Microneedle (SPM) for Intravitreal Drug Delivery

KangJu Lee et al.

Summary: Intravitreal injection is a common technology used for treating ophthalmic diseases, but it may have side effects. Researchers have developed a self-plugging microneedle that can deliver drugs and seal the scleral puncture simultaneously, reducing the occurrence of side effects.

ADVANCED HEALTHCARE MATERIALS (2022)

Add to Collection

Article Materials Science, Biomaterials

Photocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforations

Rumeysa Tutar et al.

Summary: A biocompatible and photocrosslinkable ocular tissue adhesive composite hydrogel was synthesized for use in corneal injuries, showing improved adhesion behaviors with the presence of silk fibroin. The material exhibited high physiological adhesion and could be modulated to increase adhesive strength up to 3 times. Furthermore, the hydrogel also supported cellular adhesion and proliferation, with a burst pressure strength higher than traditional sealants.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Smart Wireless Near-Infrared Light Emitting Contact Lens for the Treatment of Diabetic Retinopathy

Geon-Hui Lee et al.

Summary: A noninvasive smart wireless LED contact lens has been developed for the treatment of diabetic retinopathy, showing significantly improved compliance, reduced retinal vascular hyper-permeability, and confirmed safety and feasibility for treating the condition. This platform technology has the potential for various biomedical photonic applications.

ADVANCED SCIENCE (2022)

Add to Collection

Article Engineering, Biomedical

In vitro and in vivo evaluation of brimonidine loaded silica nanoparticles-laden silicone contact lenses to manage glaucoma

Yunli Xu et al.

Summary: In this study, a novel drug-loaded contact lens was developed for the treatment of glaucoma. The contact lens, which contained brimonidine-loaded silica nanoparticles, demonstrated controlled drug release without altering the optophysical properties of the lens. The experimental results showed that the contact lens had good biocompatibility and effective drug release.

JOURNAL OF BIOMATERIALS APPLICATIONS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Ocular delivery of cyclosporine A using dissolvable microneedle contact lens

Deepanjan Datta et al.

Summary: A rapidly dissolving polymeric microneedle ocular patch (MOP) was fabricated to effectively deliver cyclosporine A (CsA) within the cornea.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

Add to Collection

Article Pharmacology & Pharmacy

Almond oil O/W nanoemulsions: Potential application for ocular delivery

Patrizia Nadia Hanieh et al.

Summary: The study aimed to develop oil-in-water nanoemulsions to extend the residence time of ophthalmic drugs in the eye, improving patient compliance.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Cheng Yang et al.

Summary: The study presents an integrated wireless theranostic contact lens that can wirelessly track intraocular pressure and offer on-demand anti-glaucoma drug delivery. The contact lens has a compact design, with a highly sensitive intraocular pressure sensing module and an efficient drug delivery module, making it a promising system for glaucoma treatments.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Multidisciplinary Sciences

Biodegradable silicon nanoneedles for ocular drug delivery

Woohyun Park et al.

Summary: This article introduces a unique platform for ocular drug delivery, which integrates silicon nanoneedles with tear-soluble contact lenses. The platform enables painless and long-term sustained delivery of ocular drugs, and has shown effectiveness in treating chronic ocular diseases.

SCIENCE ADVANCES (2022)

Add to Collection

Article Engineering, Biomedical

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

Yi Han et al.

Summary: The development of a novel temperature-sensitive hydrogel can improve the solubility and retention time of drugs on the ocular surface, providing an effective treatment for dry eye.

BIOACTIVE MATERIALS (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

User-demand fast-curable ocular glues enforced by multilength tunable networks

Hyeseon Lee et al.

Summary: This study reports a user-demand hydrogel-forming ocular glue based on multilength photo-crosslinkable hyaluronic acid, which achieves fast and effective wound closure under wet and dynamic conditions, while possessing cornea-like transparency and lubricating properties. In animal experiments, the glue showed improved wound healing efficacy.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2022)

Add to Collection

Article Polymer Science

The Role of Multilayer Electrospun Poly(Vinyl Alcohol)/Gelatin nanofibers loaded with Fluconazole and Cinnamaldehyde in the Potential Treatment of Fungal Keratitis

Elif Ilhan et al.

Summary: In this study, polyvinyl alcohol and gelatin nanofibers with high drug loading capacity were produced by electrospinning. Cinnamaldehyde and fluconazole were incorporated into the nanofibers to inhibit the growth and biofilm formation of Candida albicans. The nanofibers exhibited significant antifungal activity and inhibited biofilm formation.

EUROPEAN POLYMER JOURNAL (2022)

Add to Collection

Article Multidisciplinary Sciences

Wireless theranostic smart contact lens for monitoring and control of intraocular pressure in glaucoma

Tae Yeon Kim et al.

Summary: In this study, a precisely integrated theranostic smart contact lens was developed for monitoring and controlling intraocular pressure in glaucoma patients, offering potential personalized healthcare for glaucoma and other ocular diseases.

NATURE COMMUNICATIONS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

New Aspects on the Treatment of Retinopathy of Prematurity: Currently Available Therapies and Emerging Novel Therapeutics

Juhee Ryu

Summary: Retinopathy of prematurity (ROP) is a proliferative ocular disorder in preterm infants and is now one of the leading causes of childhood blindness. Current treatment methods have limitations, highlighting the need for novel therapeutics with minimal adverse effects for ROP.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Pharmacology & Pharmacy

Customized cationic nanoemulsions loading triamcinolone acetonide for corneal neovascularization secondary to inflammatory processes

Ana R. Fernandes et al.

Summary: Customized cationic oil-in-water nanoemulsions were developed to enhance the bioavailability of poorly water-soluble drugs. The nanoemulsions showed high corneal penetration and stability, and demonstrated significant improvement in ocular inflammation and reduction in the risk of inflammatory processes.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Add to Collection

Editorial Material Ophthalmology

Nanotechnology and drug delivery systems for topical ocular therapy: a promising new chapter

Sathiship Srinivasan

JOURNAL OF CATARACT AND REFRACTIVE SURGERY (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Dissolving microneedles: Applications and growing therapeutic potential

Ziad Sartawi et al.

Summary: This review discusses the recent developments and trends of dissolving microneedles as a drug delivery system, highlighting their advantages over coated and hollow microneedles. It emphasizes the potential applications of dissolving microneedles in various therapeutic areas and addresses current trends in the microneedle landscape, including clinical trials and commercial successes.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection

Review Immunology

Nanoparticle-Based Delivery Systems for Vaccines

Rajashri Bezbaruah et al.

Summary: Vaccination remains the most cost-effective method to combat infectious illnesses. A new class of nanoparticle-based vaccines has shown promise in addressing the shortcomings of traditional vaccines, offering improved antigen presentation and immunogenicity through precise regulation of nanoparticle characteristics.

VACCINES (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update

Mehrdad Afarid et al.

Summary: Ocular drug delivery is challenging but nanotechnology offers opportunities to overcome the limitations of common ocular delivery systems. This review highlights recent achievements in nano-based technologies for ocular disease diagnosis and treatment.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Add to Collection

Article Chemistry, Applied

N-acetylcysteine functionalized chitosan oligosaccharide-palmitic acid conjugate enhances ophthalmic delivery of flurbiprofen and its mechanisms

Yuhui Sheng et al.

Summary: An N-acetylcysteine functionalized chitosan oligosaccharide-palmitic acid conjugate (NAC-COS-PA) was synthesized for enhanced transocular drug delivery. The conjugate exhibited good biocompatibility and increased drug permeation. In vivo studies showed that NAC-COS-PA-FB had superior anti-inflammatory efficacy compared to other nanomicelles and solution.

CARBOHYDRATE POLYMERS (2022)

Add to Collection

Article Chemistry, Applied

Biomedical engineering of polysaccharide-based tissue adhesives: Recent advances and future direction

Hanieh Shokrani et al.

Summary: Tissue adhesives are widely used for wound treatment, prevention of wound leaks, severe bleeding, and drug delivery. Future research needs to focus on understanding biomaterials, tissue surface properties, fabrication procedures, and the development of new adhesive technologies.

CARBOHYDRATE POLYMERS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Melatonin loaded hybrid nanomedicine: DoE approach, optimization and in vitro study on diabetic retinopathy model

Alessia Romeo et al.

Summary: This study designed and optimized melatonin-loaded lipid-polymer hybrid nanoparticles (mel-LPHNs) for the topical management of retinal diseases. The optimized nanomedicine showed suitable characteristics for ophthalmic administration, including good mucoadhesive properties, controlled release profile, and increased neuroprotective and antioxidant activities compared to melatonin aqueous solution. The development of mel-LPHNs provides a novel and safe hybrid platform for the localized treatment of retinal diseases.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Add to Collection

Review Pharmacology & Pharmacy

3D printing in Ophthalmology: From medical implants to personalised medicine

Greymi Tan et al.

Summary: 3D printing has become increasingly important in healthcare, with applications in drug delivery, organ transplants, and surgical planning. Customized medical devices and implants provide more personalized treatment options for patients.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Rebamipide liposome as an effective ocular delivery system for the management of dry eye disease

Han Qiao et al.

Summary: In this study, RBM liposomal eye drops were designed and optimized for the treatment of dry eye disease (DED). The RBM liposomes showed better stability, slow-release rate, and longer residence time on the ocular surface compared to suspensions. They reduced the drug dose and irritation to the ocular surface while maintaining the same efficacy and increasing the concentration in the cornea and aqueous humor.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Polymeric microneedles for transdermal drug delivery- a review of recent studies

Ziaul Karim et al.

Summary: Transdermal drug delivery is a highly attractive route for administering pharmaceutical active ingredients. Microneedle technology, with its advantages of efficiency, painlessness, reliability, and feasibility, has gained prominence in transdermal drug delivery. Different types of microneedles can be made using various materials based on the delivery mechanism, offering promising applications.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Recent advances in microneedle designs and their applications in drug and cosmeceutical delivery

Rabinarayan Parhi

Summary: With the development of microneedles technology, transdermal drug delivery has overcome the barrier of the skin and can deliver various drugs and biomolecules. In addition, microneedles technology can overcome other biological barriers on non-transdermal routes and offers advantages in personalized drug delivery systems.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

Add to Collection

Article Chemistry, Physical

Non-invasive drug delivery systems mediated by nanocarriers and molecular dynamics simulation for posterior eye disease therapeutics: Virtual screening, construction and comparison

Tingting Zhang et al.

Summary: Through molecular dynamics analysis, polymer-based nanomicelles were found to have a more significant effect on improving ocular drug absorption, making them a potential candidate as a nanocarrier for treating ocular diseases.

JOURNAL OF MOLECULAR LIQUIDS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Hydrogel-Based Smart Contact Lens for Highly Sensitive Wireless Intraocular Pressure Monitoring

Hengtian Zhu et al.

Summary: This research proposes a method for producing hydrogel-based smart contact lenses that can monitor intraocular pressure wirelessly. The contact lenses show excellent potential for clinical application and promise for next-generation daily ocular health management.

ACS SENSORS (2022)

Add to Collection

Article Pharmacology & Pharmacy

A Simple, Safe, and Effective Method for Preparing Autologous Bio-Based Fibrin Glue for Ophthalmic Use

Luis Fernandez-Vega-Cueto et al.

Summary: The study proposes a method to prepare autologous bio-based fibrin glue for ophthalmic surgery. The adhesive strength of FG increased with fibrinogen concentration, and FG2 and FG3 showed successful results in conjunctival autografts with equivalent properties compared to commercial FG and reduced inflammation.

PHARMACEUTICS (2022)

Add to Collection

Review Materials Science, Biomaterials

An update on biomaterials as microneedle matrixes for biomedical applications

Xiao Peng Zhang et al.

Summary: This review article summarizes and evaluates the matrix materials currently used for preparing microneedles, including their low toxicity, biocompatibility, biodegradability, and mechanical properties. In addition, it also summarizes the microneedle products available on the market and their applications, providing researchers with basic information for material selection and development.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Add to Collection

Article Materials Science, Biomaterials

Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye

Yu Wu et al.

Summary: An alternative system of nanosuspensions (NS) and dissolving microneedles (MNs) was developed for the minimally invasive transscleral delivery of hydrophobic drugs. The optimized NS-loaded MNs demonstrated higher drug deposition and better penetration compared to plain drug-loaded MNs. The developed hybrid system showed excellent biocompatibility with ocular tissues and could potentially be used as an effective and minimally invasive technology for the treatment of retinal diseases.

BIOMATERIALS ADVANCES (2022)

Add to Collection

Article Chemistry, Physical

Timolol loaded microemulsion laden silicone contact lens to manage glaucoma: in vitro and in vivo studies

Ning Wei et al.

Summary: The research demonstrates that soaking timolol in microemulsion can improve the loading capacity and release kinetics, without affecting the swelling and transmittance of contact lenses. The use of timolol-microemulsion soaking solution prolongs the release time of timolol in contact lenses effectively.

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY (2021)

Add to Collection

Review Chemistry, Analytical

Recent Advances in Microneedle-Based Sensors for Sampling, Diagnosis and Monitoring of Chronic Diseases

Ozgecan Erdem et al.

Summary: Chronic diseases are noncommunicable illnesses with long-term symptoms, accurate biomarker detection is crucial for their diagnosis and prognosis. Innovative strategies for point-of-care settings are needed, and microneedle technology has emerged as a revolutionary approach in biosensing strategies. Various microneedle-based platforms have been developed for real-time monitoring of CD-associated biomarkers.

BIOSENSORS-BASEL (2021)

Add to Collection

Article Pharmacology & Pharmacy

Formulation of nanoparticles loaded in situ gel for treatment of dry eye disease: In vitro, ex vivo and in vivo evidences

Umesh D. Laddha et al.

Summary: Researchers developed a novel ocular drug delivery system using poly (D, L-lactide-co-glycolide) nanoparticles and temperature-sensitive in situ gel. The optimized formulation showed good biocompatibility and effectiveness in stabilizing tear film and alleviating dry eye syndrome compared to existing marketed formulations.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

Add to Collection

Review Instruments & Instrumentation

Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives

Sherif A. Gaballa et al.

Summary: Corticosteroids are the mainstay of treatment for various ocular conditions due to their anti-inflammatory properties. Different routes of administration can enhance therapeutic effects but also pose significant local risks, including intraocular pressure elevation and cataract formation.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

Add to Collection

Article Biophysics

Three dimensional bioprinting technology: Applications in pharmaceutical and biomedical area

Esen Kocak et al.

Summary: 3D bioprinting is a technology that prints designed biological materials in three dimensions, with applications in producing tissues, organs, cells, and blood vessels for transplantation. It also finds uses in modeling, drug delivery systems, and drug screening. Despite limitations, this technology is of great significance in the medical field.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Add to Collection

Review Ophthalmology

Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance

Darren Shu Jeng Ting et al.

Summary: Corneal opacity is the 5th leading cause of blindness globally, and infectious keratitis (IK) is the main cause of corneal blindness in both developed and developing countries. Bacteria and fungi are the most common causative microorganisms, with major risk factors including contact lens wear and ocular surface diseases. Broad-spectrum topical antimicrobial treatment is the mainstay of treatment for IK, although antimicrobial resistance poses a challenge in some parts of the world.

EYE (2021)

Add to Collection

Article Biophysics

Evaluation of silicone hydrogel contact lenses based on poly (dimethylsiloxane) dialkanol and hydrophilic polymers

Nguyen-Phuong-Dung Tran et al.

Summary: Silicone hydrogel lenses were prepared by copolymerizing PDMS-PEGMA macromer (PGP) with various substances, showing higher water uptake ability and oxygen permeability. They also exhibited good optical transparency, anti-protein deposition, and non-cytotoxicity.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye

Alexander Vaneev et al.

Summary: Topical drug delivery for eye therapy is challenging due to short retention time, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Various conventional and novel drug delivery systems, particularly nanosize carriers, have been developed to improve drug bioavailability and enhance therapeutic action for eye diseases. Promising results have been shown with drug-loaded nanoparticles for sustained drug release and improved efficacy in vitro and in vivo.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Nanoscience & Nanotechnology

Assessment to the Antifungal Effects in vitro and the Ocular Pharmacokinetics of Solid-Lipid Nanoparticle in Rabbits

Zhen Liang et al.

Summary: The solid-lipid nanoparticle-based ECZ eye drops (E-SLNs) showed improved corneal permeability and antifungal activity without irritation compared to ECZ Suspension (E-Susp). E-SLNs exhibited controlled release and enhanced ocular bioavailability, making them a promising therapeutic approach for fungal keratitis and potentially other ocular diseases.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Add to Collection

Review Pharmacology & Pharmacy

Advances and challenges in the nanoparticles-laden contact lenses for ocular drug delivery

Furqan A. Maulvi et al.

Summary: The delivery of drugs to ocular tissues can be challenging, and drug-laden contact lenses are being explored as a possible solution. However, there are several issues that need to be addressed before clinical application and commercialization, such as changes in contact lens properties during manufacture.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Development of topical eye-drops of lactoferrin-loaded biodegradable nanoparticles for the treatment of anterior segment inflammatory processes

Ana Lopez-Machado et al.

Summary: The study successfully incorporated lactoferrin into nanoparticles, achieving a monodisperse population with prolonged release profile of lactoferrin. These nanoparticles exhibited significantly enhanced anti-inflammatory efficacy, both in cell culture and preclinical assays.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery

Dawin Khiev et al.

Summary: Nanotechnology plays a crucial role in treating ocular diseases by providing advantages such as sustained drug release and specific tissue targeting, as well as overcoming the blood-retinal barrier to increase drug bioavailability.

NANOMATERIALS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Alginate nanoparticles as ocular drug delivery carriers

Sogol Kianersi et al.

Summary: The eye is the most susceptible organ of the body, requiring a special drug delivery system to improve drug bioavailability and reduce dosing frequency. By preparing alginate nanoparticles and conducting coating modification, sustained drug release, increased drug adhesion to ocular tissue, and decreased need for duplicate treatment can be achieved.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Polymeric Tissue Adhesives

Sungmin Nam et al.

Summary: Polymeric tissue adhesives are versatile materials widely used in wound management, offering relative ease of use and rapid application while also acting as hemostats. Despite facing challenges, advancements in tissue adhesives may provide new possibilities for wound care.

CHEMICAL REVIEWS (2021)

Add to Collection

Review Medicine, Research & Experimental

Panorama of dissolving microneedles for transdermal drug delivery

Mayuri Dalvi et al.

Summary: The article discusses the application of microfabrication technology in enhancing the permeability of drugs for transdermal delivery, with a focus on the composition, fabrication techniques, and applications of microneedles. Microneedles can be classified into different types and are primarily used for delivering low molecular weight drugs, peptides, enzymes, vaccines, and bio-therapeutics.

LIFE SCIENCES (2021)

Add to Collection

Article Pharmacology & Pharmacy

Microneedle array systems for long-acting drug delivery

Lalit K. Vora et al.

Summary: The development of microneedles (MNs) assisted drug delivery technologies has been active for over two decades. Different types of MNs are designed to deliver therapeutic materials directly into the dermal and ocular space for sustained or controlled release of active ingredients. Challenges lie ahead in realizing the full potential of sustained-release long-acting MNs in clinical applications.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

Add to Collection

Review Pharmacology & Pharmacy

Hollow microneedles: A perspective in biomedical applications

Alvaro Carcamo-Martinez et al.

Summary: Microneedles have the potential to be a highly progressive device for drug delivery and monitoring purposes by penetrating the skin and piercing the stratum corneum barrier. Hollow microneedles have entered the pharmaceutical market as medical devices, with continuous development in materials and methods for fabrication, and expanding applications in drug delivery, vaccine delivery, and monitoring.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Tissue adhesives: From research to clinical translation

Ayca Bal-Ozturk et al.

Summary: Tissue adhesives serve as an interface to connect the surfaces of wound edges and prevent them from separation, offering new possibilities for wound closure. The chemical properties of these products play a crucial role in their commercial success in clinical applications.

NANO TODAY (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Multifaceted Design and Emerging Applications of Tissue Adhesives

Zhenwei Ma et al.

Summary: Tissue adhesives have a wide range of applications and numerous advantages, and are currently in a phase of rapid development. The key elements of their design have been comprehensively discussed, while opportunities for improvement and further development have also been suggested.

ADVANCED MATERIALS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Next -generation contact lenses: Towards bioresponsive drug delivery and smart technologies in ocular therapeutics

Pinal Chaudhari et al.

Summary: Contact lenses have diverse applications including bio-sensing, prevention of myopia, cosmetics, and drug delivery. Researchers have developed new approaches such as bioinspired polymeric systems and stimuli-responsive systems to overcome the disadvantages of medicated contact lenses. Recent innovations in ocular therapeutics have also gained significant attention.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

Add to Collection

Article Materials Science, Multidisciplinary

Wearable electronic devices for glaucoma monitoring and therapy

Wanqing Zhang et al.

Summary: Glaucoma is a major cause of irreversible blindness globally, with elevated intraocular pressure being a crucial risk factor and treatment target. Therapies focus on reducing IOP to prevent disease progression, highlighting the importance of accurate real-time measurement for evaluating treatment response and guiding medical decisions.

MATERIALS & DESIGN (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Microneedles for gene and drug delivery in skin cancer therapy

Defu Zhi et al.

Summary: Microneedles are an effective delivery method for skin cancer treatment, providing advantages such as bypassing the stratum corneum barrier, delivering drugs and genes in a simple, safe, and painless manner, and improving therapeutic effects. The combination of microneedles with other treatment strategies like photothermal therapy shows promise in enhancing the overall treatment outcomes for skin cancer.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection

Review Polymer Science

Contact Lenses as Ophthalmic Drug Delivery Systems: A Review

Paola Franco et al.

Summary: Ophthalmic drugs are commonly administered through eye drops, but a low bioavailability of the active principle is a common issue. Recent advancements in using therapeutic contact lenses, which are loaded with drugs and directly target the organ, have shown promising results in promoting prolonged release of active principles. Innovative methods like impregnation with supercritical carbon dioxide have been proposed to enhance the therapeutic performance of drug-loaded contact lenses. This updated review provides valuable information on preparation methodologies, recent achievements, and future perspectives in the field of therapeutic contact lenses.

POLYMERS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Long-acting nanoparticle-loaded bilayer microneedles for protein delivery to the posterior segment of the eye

Yu Wu et al.

Summary: The research focuses on developing a sustained drug delivery system for neovascular ocular diseases using nanoparticle-loaded bilayer dissolving microneedle arrays. By optimizing the preparation of nanoparticles and the design of microneedles, the study achieved sustained release of protein drugs, potentially offering an effective therapy for treating the diseases.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Thermosensitive and mucoadhesive in situ ocular gel for effective local delivery and antifungal activity of itraconazole nanocrystal in the treatment of fungal keratitis

Andi Dian Permana et al.

Summary: This study focused on incorporating itraconazole into nanocrystalline carrier system with Pluronic (R) F127 stabilizer and formulating it into thermosensitive in situ ocular gel, showing improved antifungal activity against Candida albicans. The optimized gel base demonstrated better therapeutic effect on infected porcine eye models, with a 93% decrease in the CA population after 48 hours.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection

Article Engineering, Biomedical

Sutureless Transplantation of Amniotic Membrane Using a Visible Light-Curable Protein Bioadhesive for Ocular Surface Reconstruction

Seong-Woo Maeng et al.

Summary: Transplantation of the amniotic membrane (AM) is highlighted as an efficient method to cure conjunctiva defects with advantages of no side effects compared to mitomycin C treatment and not leaving additional scars on donor site compared to conjunctival autografting. However, simplification of the procedure is necessary to minimize additional damage to the ocular surface.

ADVANCED HEALTHCARE MATERIALS (2021)

Add to Collection

Review Ophthalmology

Pharmaceutical-loaded contact lenses as an ocular drug delivery system: A review of critical lens characterization methodologies with reference to ISO standards

Dan Chau Thuy Nguyen et al.

Summary: Therapeutic contact lenses for ocular drug delivery have shown potential in enhancing ocular bioavailability, increasing patient compliance, and reducing side effects, but challenges remain in terms of drug stability and lens properties.

CONTACT LENS & ANTERIOR EYE (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Zhao Wang et al.

Summary: Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability were successfully developed using drug-loaded nanogels. These contact lenses can sustainably deliver drugs and exhibit good biocompatibility compared to traditional eye drops or ointment formulations, making them a promising alternative for long-term oculopathy treatment.

NANOMATERIALS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Recent Advances in Hydrogels: Ophthalmic Applications in Cell Delivery, Vitreous Substitutes, and Ocular Adhesives

Kenny T. Lin et al.

Summary: Various treatments have been developed for eye diseases like cataracts and retinal degenerative diseases, but they come with their own shortcomings. The use of hydrogel technology has been a critical focus in overcoming the limitations of current treatments.

BIOMEDICINES (2021)

Add to Collection

Article Chemistry, Multidisciplinary

NIR-triggered upconversion nanoparticles@thermo-sensitive liposome hybrid theranostic nanoplatform for controlled drug delivery

Yibin Yu et al.

Summary: The study introduced a novel nanoplatform designed for the treatment and diagnosis of posterior segment ocular diseases by utilizing a combination of different nanomaterials. The nanoplatform showed potential therapeutic and diagnostic value targeting the retina, providing new insights and approaches for the treatment of posterior segment eye diseases.

RSC ADVANCES (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Therapeutic Contact Lens for Scavenging Excessive Reactive Oxygen Species on the Ocular Surface

Seung Woo Choi et al.

ACS NANO (2020)

Add to Collection

Article Materials Science, Multidisciplinary

Biocompatible 3D Printed Microneedles for Transdermal, Intradermal, and Percutaneous Applications

Khalil Moussi et al.

ADVANCED ENGINEERING MATERIALS (2020)

Add to Collection

Article Pharmacology & Pharmacy

New nanoparticles for topical ocular delivery of erythropoietin

Beatriz Silva et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection

Article Pharmacology & Pharmacy

Novel ultrasmall nanomicelles based on rebaudioside A: A potential nanoplatform for the ocular delivery of pterostilbene

Kaichao Song et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection

Review Engineering, Biomedical

Therapeutic contact lenses for ophthalmic drug delivery: major challenges

Xiuju Zhang et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2020)

Add to Collection

Article Pharmacology & Pharmacy

Development of thermosensitive in situ gel nanoemulsions for ocular delivery of acyclovir

Mohammad Mehdi Mahboobian et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

Add to Collection

Review Medicine, Research & Experimental

Bio-tactics for neuroprotection of retinal ganglion cells in the treatment of glaucoma

Khushwant S. Yadav et al.

LIFE SCIENCES (2020)

Add to Collection

Article Polymer Science

Chitosan surface modified hydrogel as a therapeutic contact lens

Mohammad Kazemi Ashtiani et al.

POLYMERS FOR ADVANCED TECHNOLOGIES (2020)

Add to Collection

Article Pharmacology & Pharmacy

A stepwise optimization strategy to formulate in situ gelling formulations comprising fluconazole-hydroxypropyl-beta-cyclodextrin complex loaded niosomal vesicles and Eudragit nanoparticles for enhanced antifungal activity and prolonged ocular delivery

Heba Elmotasem et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Add to Collection

Review Engineering, Biomedical

Surgical applications of intracorporal tissue adhesive agents: current evidence and future development

Nicholas Gillman et al.

EXPERT REVIEW OF MEDICAL DEVICES (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Polysaccharide as renewable responsive biopolymer for in situ gel in the delivery of drug through ocular route

Anindita Chowhan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Add to Collection

Article Engineering, Biomedical

Ofloxacin laden microemulsion contact lens to treat conjunctivitis

Yanchun Li et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2020)

Add to Collection

Article Instruments & Instrumentation

Atorvastatin-loaded solid lipid nanoparticles as eye drops: proposed treatment option for age-related macular degeneration (AMD)

Monika Yadav et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

Add to Collection

Article Ophthalmology

Stimulus-Responsive Contact Lens for IOP Measurement or Temperature-Triggered Drug Release

Se-Hee Lee et al.

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Wireless smart contact lens for diabetic diagnosis and therapy

Do Hee Keum et al.

SCIENCE ADVANCES (2020)

Add to Collection

Article Materials Science, Multidisciplinary

Rapidly Detachable Microneedles Using Porous Water-Soluble Layer for Ocular Drug Delivery

YeJin Lee et al.

ADVANCED MATERIALS TECHNOLOGIES (2020)

Add to Collection

Article Engineering, Biomedical

Dually functional hollow ceria nanoparticle platform for intraocular drug delivery: A push beyond the limits of static and dynamic ocular barriers toward glaucoma therapy

Li-Jyuan Luo et al.

BIOMATERIALS (2020)

Add to Collection

Article Pharmacology & Pharmacy

Nanoemulsion as a feasible and biocompatible carrier for ocular delivery of travoprost: Improved pharmacokinetic/pharmacodynamic properties

Ayman Ismail et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection

Review Pharmacology & Pharmacy

Microneedle-Based Delivery: An Overview of Current Applications and Trends

Antonio Jose Guillot et al.

PHARMACEUTICS (2020)

Add to Collection

Article Pharmacology & Pharmacy

Travoprost loaded microemulsion soaked contact lenses: Improved drug uptake, release kinetics and physical properties

Bing Xu et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

Add to Collection

Review Engineering, Biomedical

Evaluation of commercial soft contact lenses for ocular drug delivery: A review

Xin Fan et al.

ACTA BIOMATERIALIA (2020)

Add to Collection

Article Materials Science, Biomaterials

Surface modified electrospun poly(lactic acid) fibrous scaffold with cellulose nanofibrils and Ag nanoparticles for ocular cell proliferation and antimicrobial application

Dan Yan et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Add to Collection

Article Ophthalmology

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1)

Felipe A. Medeiros et al.

OPHTHALMOLOGY (2020)

Add to Collection

Article Nanoscience & Nanotechnology

Self-assembled DNA nanoparticles loaded with travoprost for glaucoma-treatment

Sven Schnichels et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Defining Dry Eye from a Clinical Perspective

Kazuo Tsubota et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Pharmacology & Pharmacy

Microneedles Drug Delivery Systems for Treatment of Cancer: A Recent Update

Aravindram Attiguppe Seetharam et al.

PHARMACEUTICS (2020)

Add to Collection

Article Toxicology

Investigating the ocular toxicity potential and therapeutic efficiency of in situ gel nanoemulsion formulations of brinzolamide

Sima Talaei et al.

TOXICOLOGY RESEARCH (2020)

Add to Collection

Article Ophthalmology

ABCD: A new classification for keratoconus

Michael W. Belin et al.

INDIAN JOURNAL OF OPHTHALMOLOGY (2020)

Add to Collection

Article Pharmacology & Pharmacy

Extended levobunolol release from Eudragit nanoparticle-laden contact lenses for glaucoma therapy

Navneet Kumar et al.

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Add to Collection

Review Chemistry, Medicinal

Nanotechnology for the Treatment of Allergic Conjunctival Diseases

Yu-Chi Liu et al.

PHARMACEUTICALS (2020)

Add to Collection

Article Materials Science, Biomaterials

Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

Yishun Guo et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Add to Collection

Article Materials Science, Biomaterials

Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications

Islam A. Khalil et al.

BIOMATERIALS SCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels

Ehsan Shirzaei Sani et al.

SCIENCE ADVANCES (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Natamycin solid lipid nanoparticles - sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization

Ahmed Khames et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Add to Collection

Article Pharmacology & Pharmacy

A novel FK506 loaded nanomicelles consisting of amino-terminated poly (ethylene glycol)-block-poly(D,L)-lactic acid and hydroxypropyl methylcellulose for ocular drug delivery

Dong Liu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Add to Collection

Review Engineering, Biomedical

Recent Trends in Advanced Contact Lenses

Zeynep Mutlu et al.

ADVANCED HEALTHCARE MATERIALS (2019)

Add to Collection

Article Pharmacology & Pharmacy

Designing of a pH-Triggered Carbopol®/HPMC In Situ Gel for Ocular Delivery of Dorzolamide HCl: In Vitro, In Vivo, and Ex Vivo Evaluation

Maryam Kouchak et al.

AAPS PHARMSCITECH (2019)

Add to Collection

Article Ophthalmology

Management of Ocular Allergy Itch With an Antihistamine-Releasing Contact Lens

Brian Pall et al.

CORNEA (2019)

Add to Collection

Review Pharmacology & Pharmacy

Challenges and opportunities for drug delivery to the posterior of the eye

Fernando J. Cabrera et al.

DRUG DISCOVERY TODAY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Current Trends and Future Perspective of Mesenchymal Stem Cells and Exosomes in Corneal Diseases

Hassan Mansoor et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Pharmacology & Pharmacy

Treatment of endotoxin-induced uveitis by topical application of cyclosporine a-loaded PolyGel™ in rabbit eyes

Aws Alshamsan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Co-delivery of latanoprost and timolol from micelles-laden contact lenses for the treatment of glaucoma

Jiawen Xu et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Add to Collection

Review Chemistry, Multidisciplinary

Safety Assessment of Nanomaterials to Eyes: An Important but Neglected Issue

Shuang Zhu et al.

ADVANCED SCIENCE (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Proteomic Biomarkers of Retinal Inflammation in Diabetic Retinopathy

Hannah Youngblood et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Review Pharmacology & Pharmacy

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Xiaoxiang He et al.

DOSE-RESPONSE (2019)

Add to Collection

Article Engineering, Electrical & Electronic

A Multifunctional Smart Soft Contact Lens Device Enabled by Nanopore Thin Film for Glaucoma Diagnostics and In Situ Drug Delivery

Chao Song et al.

JOURNAL OF MICROELECTROMECHANICAL SYSTEMS (2019)

Add to Collection

Review Medicine, Research & Experimental

Applications of microneedles in delivering drugs for various ocular diseases

Pallavi Gupta et al.

LIFE SCIENCES (2019)

Add to Collection

Article Engineering, Biomedical

Effect of gold nanoparticles on timolol uptake and its release kinetics from contact lenses: In vitro and in vivo evaluation

Furqan A. Maulvi et al.

ACTA BIOMATERIALIA (2019)

Add to Collection

Review Pharmacology & Pharmacy

Choroidal Neovascularization: Mechanisms of Endothelial Dysfunction

Natalie Jia Ying Yeo et al.

FRONTIERS IN PHARMACOLOGY (2019)

Add to Collection

Review Engineering, Biomedical

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Grissel Trujillo-de Santiago et al.

BIOMATERIALS (2019)

Add to Collection

Review Pharmacology & Pharmacy

Transdermal Microneedles-A Materials Perspective

R. Ali et al.

AAPS PHARMSCITECH (2019)

Add to Collection

Article Pharmacology & Pharmacy

Amphotericin B containing microneedle ocular patch for effective treatment of fungal keratitis

Girdhari Roy et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Add to Collection

Article Pharmacology & Pharmacy

Bimatoprost loaded microemulsion laden contact lens to treat glaucoma

Wenwen Xu et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Drug-eluting contact lens containing cyclosporine-loaded cholesterol-hyaluronate micelles for dry eye syndrome

Jonghwan Mun et al.

RSC ADVANCES (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Microneedle-based drug delivery: materials of construction

Shubhmita Bhatnagar et al.

JOURNAL OF CHEMICAL SCIENCES (2019)

Add to Collection

Article Pharmacology & Pharmacy

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

Principia Dardano et al.

ADVANCED THERAPEUTICS (2019)

Add to Collection

Review Pharmacology & Pharmacy

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

Abhirup Mandal et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Add to Collection

Article Engineering, Biomedical

DNA nanoparticles for ophthalmic drug delivery

Jan Willem de Vries et al.

BIOMATERIALS (2018)

Add to Collection

Review Chemistry, Multidisciplinary

A comprehensive review on contact lens for ophthalmic drug delivery

Jiawen Xu et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Add to Collection

Article Polymer Science

Surface modification of poly(2-hydroxyethyl methacrylate) hydrogel for contact lens application

Mohammad Kazemi Ashtiani et al.

POLYMERS FOR ADVANCED TECHNOLOGIES (2018)

Add to Collection

Article Multidisciplinary Sciences

Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion

Kazuaki Kadonosono et al.

SCIENTIFIC REPORTS (2018)

Add to Collection

Article Engineering, Biomedical

Intracorneal injection of a detachable hybrid microneedle for sustained drug delivery

KangJu Lee et al.

ACTA BIOMATERIALIA (2018)

Add to Collection

Article Medicine, Research & Experimental

Effect of nanoencapsulation using poly (lactide-co-glycolide) (PLGA) on anti-angiogenic activity of bevacizumab for ocular angiogenesis therapy

Xiao-Pei Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Ocular Drug Delivery: Role of Degradable Polymeric Nanocarriers for Ophthalmic Application

Cheng-Han Tsai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Article Multidisciplinary Sciences

Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery

Aung Than et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Review Ophthalmology

Recent developments in keratoconus diagnosis

Marcella Salomao et al.

EXPERT REVIEW OF OPHTHALMOLOGY (2018)

Add to Collection

Article Engineering, Biomedical

Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect

P. Paradiso et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2017)

Add to Collection

Review Chemistry, Multidisciplinary

Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

Abhirup Mandal et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Add to Collection

Review Pharmacology & Pharmacy

Nanotechnology-based strategies for treatment of ocular disease

Yuhua Weng et al.

ACTA PHARMACEUTICA SINICA B (2017)

Add to Collection

Review Pharmacology & Pharmacy

Development of microemulsions for ocular delivery

Nivedita Gautam et al.

THERAPEUTIC DELIVERY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Polymer Micelles Laden Hydrogel Contact Lenses for Ophthalmic Drug Delivery

Xiaohong Hu et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2016)

Add to Collection

Review Materials Science, Multidisciplinary

Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development

Eneko Larraneta et al.

MATERIALS SCIENCE & ENGINEERING R-REPORTS (2016)

Add to Collection

Article Medicine, Research & Experimental

Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis

Daniela C. Marcano et al.

MOLECULAR PHARMACEUTICS (2016)

Add to Collection

Article Ophthalmology

Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye

Fang Bian et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Ocular Drug Delivery Nanowafer with Enhanced Therapeutic Efficacy

Xiaoyong Yuan et al.

ACS NANO (2015)

Add to Collection

Article Biochemical Research Methods

Intravitreal Injection of Anti-Vascular Endothelial Growth Factor (anti-VEGF) Antibody via Tower Microneedle

Chang Yeol Lee et al.

BIOCHIP JOURNAL (2015)

Add to Collection

Article Chemistry, Multidisciplinary

Dexamethasone nanowafer as an effective therapy for dry eye disease

Terry G. Coursey et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection

Article Ophthalmology

Intrastromal Delivery of Bevacizumab Using Microneedles to Treat Corneal Neovascularization

Yoo C. Kim et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2014)

Add to Collection

Review Nanoscience & Nanotechnology

Liposomes and nanotechnology in drug development: focus on ocular targets

Miki Honda et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2013)

Add to Collection

Article Chemistry, Multidisciplinary

Glaucoma therapy by extended release of timolol from nanoparticle loaded silicone-hydrogel contact lenses

Hyun Jung Jung et al.

JOURNAL OF CONTROLLED RELEASE (2013)

Add to Collection

Article Chemistry, Medicinal

Hydrogel containing silica shell cross-linked micelles for ocular drug delivery

Changhai Lu et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

Add to Collection

Article Ophthalmology

Endovascular Cannulation With a Microneedle for Central Retinal Vein Occlusion

Kazuaki Kadonosono et al.

JAMA OPHTHALMOLOGY (2013)

Add to Collection

Article Ophthalmology

Treatment of Acute Posterior Uveitis in a Porcine Model by Injection of Triamcinolone Acetonide Into the Suprachoroidal Space Using Microneedles

Brian C. Gilger et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)

Add to Collection

Review Nanoscience & Nanotechnology

Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery

B. Mishra et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2010)

Add to Collection

Article Biotechnology & Applied Microbiology

Improved Retinal Function in a Mouse Model of Dominant Retinitis Pigmentosa Following AAV-delivered Gene Therapy

Naomi Chadderton et al.

MOLECULAR THERAPY (2009)

Add to Collection

Article Chemistry, Medicinal

Antibacterial activity of contact lenses bearing surface-immobilized layers of intact Liposomes loaded with Levofloxacin

Anne Danion et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2007)

Add to Collection

Article Engineering, Biomedical

Fabrication and characterization of contact lenses bearing surface-immobilized layers of intact liposomes

Anne Danion et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2007)

Add to Collection

Article Ophthalmology

Coated microneedles for drug delivery to the eye

Jason Jiang et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2007)

Add to Collection

Article Ophthalmology

Ocular surface sealants and adhesives

Subir Singh Bhatia

OCULAR SURFACE (2006)

Add to Collection

Review Clinical Neurology

The neuro-ophthalmology of multiple sclerosis

EM Frohman et al.

LANCET NEUROLOGY (2005)

Add to Collection

Article Chemistry, Analytical

A micromachined chip-based electrospray source for mass spectrometry

L Licklider et al.

ANALYTICAL CHEMISTRY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.