Related references
Note: Only part of the references are listed.Synthesis of Some Novel 2-{Pyrano[2,3-c]Pyrazoles-4-Ylidene}Malononitrile Fused with Pyrazole, Pyridine, Pyrimidine, Diazepine, Chromone, Pyrano[2,3-c]Pyrazole and Pyrano[2,3-d]Pyrimidine Systems as Anticancer Agents
Dina A. Bakhotmah et al.
POLYCYCLIC AROMATIC COMPOUNDS (2022)
Novel Pyridothienopyrimidine Derivatives: Design, Synthesis and Biological Evaluation as Antimicrobial and Anticancer Agents
Eman M. Mohi El-Deen et al.
MOLECULES (2022)
Role of Collagen Regulators in Cancer Treatment: A Comprehensive Review
Tanuja Angre et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2022)
FDA-Approved Small Molecule Compounds as Drugs for Solid Cancers from Early 2011 to the End of 2021
Aleksandra Sochacka-Cwikla et al.
MOLECULES (2022)
Novel pyridine and pyrimidine derivatives as promising anticancer agents: A review
Mohammed Albratty et al.
ARABIAN JOURNAL OF CHEMISTRY (2022)
Synthesis of New Pyrimidine-Triazole Derivatives and Investigation of Their Anticancer Activities
Derya Osmaniye et al.
CHEMISTRY & BIODIVERSITY (2022)
FDA Approval Summary: Cabozantinib for Differentiated Thyroid Cancer
Elizabeth S. Duke et al.
CLINICAL CANCER RESEARCH (2022)
Discovery of New Quinazoline-Based Anticancer Agents as VEGFR-2 Inhibitors and Apoptosis Inducers
M. F. Ahmed et al.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY (2022)
Synthesis, anticancer activity and docking studies of pyrazoline and pyrimidine derivatives as potential epidermal growth factor receptor (EGFR) inhibitors
Menier Al-Anazi et al.
ARABIAN JOURNAL OF CHEMISTRY (2022)
Design, synthesis, and anti-breast-cancer activity evaluation of pyrrolo(pyrido)[2,3-d]pyrimidine derivatives
Jie Ding et al.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2022)
Development of Novel Pyridine-Thiazole Hybrid Molecules as Potential Anticancer Agents
Iryna Ivasechko et al.
MOLECULES (2022)
Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
Ankit Kumar Singh et al.
PHARMACEUTICALS (2022)
Identification of Novel Cyanopyridones and Pyrido[2,3-D]Pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies
Tarfah Al-Warhi et al.
PHARMACEUTICALS (2022)
Design, synthesis and biological evaluation of spiroisoquinoline-pyrimidine derivatives as anticancer agents against MCF-7 cancer cell lines
Shruti Gupta et al.
RESULTS IN CHEMISTRY (2022)
Anti-Tumoral Effects of a (1H-Pyrrol-1-yl)Methyl-1H-Benzoimidazole Carbamate Ester Derivative on Head and Neck Squamous Carcinoma Cell Lines
Alice Nicolai et al.
PHARMACEUTICALS (2021)
FDA Supplemental Approval Summary: Lenvatinib for the Treatment of Unresectable Hepatocellular Carcinoma
Abhilasha Nair et al.
ONCOLOGIST (2021)
Design and Synthesis of Novel Imidazole Derivatives Possessing Triazole Pharmacophore with Potent Anticancer Activity, and In Silico ADMET with GSK-3β Molecular Docking Investigations
Fawzia Al-blewi et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Recent advances and prospects in gemcitabine drug delivery systems
Shweta Paroha et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)
Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity
Heba S. A. ElZahabi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Design, synthesis, anticancer activity and molecular docking analysis of novel dinitrophenylpyrazole bearing 1,2,3-triazoles
Kotyada Suryanarayana et al.
JOURNAL OF MOLECULAR STRUCTURE (2021)
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Hyuna Sung et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2021)
N-substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: Synthesis, biological activity and computational analysis
N. Perin et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Design, Synthesis, and Antipoliferative Activities of Novel Substituted Imidazole-Thione Linked Benzotriazole Derivatives
Ahdab N. Khayyat et al.
MOLECULES (2021)
Design, synthesis, anti-cancer evaluation and binding mode studies of benzimidazole/benzoxazole linked β-carboline derivatives
Reddymasu Sireesha et al.
JOURNAL OF MOLECULAR STRUCTURE (2021)
Design, Synthesis and Biological Evaluation of New Pyrimidine Derivatives as Anticancer Agents
Valentina Noemi Madia et al.
MOLECULES (2021)
Facile synthesis of C6-substituted benz[4,5]imidazo[1,2-a]quinoxaline derivatives and their anticancer evaluation
Rahul Singh et al.
ARCHIV DER PHARMAZIE (2021)
New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis
Nawaf A. Alsaif et al.
BIOORGANIC CHEMISTRY (2021)
Cinnamide derived pyrimidine-benzimidazole hybrids as tubulin inhibitors: Synthesis, in silico and cell growth inhibition studies
Sravani Sana et al.
BIOORGANIC CHEMISTRY (2021)
Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations
Wagdy M. Eldehna et al.
BIOORGANIC CHEMISTRY (2021)
Selective and effective anticancer agents: Synthesis, biological evaluation and structure-activity relationships of novel carbazole derivatives
Wenbo Huang et al.
BIOORGANIC CHEMISTRY (2021)
Lossen Rearrangement of p-Toluenesulfonates of N-Oxyimides in Basic Condition, Theoretical Study, and Molecular Docking
Monika Kijewska et al.
FRONTIERS IN CHEMISTRY (2021)
Synthesis and anticancer activity of ethyl 5-amino-1-N-substituted-imidazole-4-carboxylate building blocks
Zukela Ruzi et al.
ARCHIV DER PHARMAZIE (2021)
Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway
Zhengjie Wang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2021)
Synthesis, docking, machine learning and antiproliferative activity of the 6-ferrocene/heterocycle-2-aminopyrimidine and 5-ferrocene-1H-Pyrazole derivatives obtained by microwave-assisted Atwal reaction as potential anticancer agents
Eclair Venturini Filho et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)
Discovery of thieno[2,3-d]pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents
Souad A. El-Metwally et al.
BIOORGANIC CHEMISTRY (2021)
Design, synthesis and biological evaluation of novel imidazole-chalcone derivatives as potential anticancer agents and tubulin polymerization inhibitors
Sara Rahimzadeh Oskuei et al.
BIOORGANIC CHEMISTRY (2021)
Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation
Khaled El-Adl et al.
BIOORGANIC CHEMISTRY (2021)
An update of new small-molecule anticancer drugs approved from 2015 to 2020
Xiaoxia Liang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Coumarin-carbazole based functionalized pyrazolines: synthesis, characterization, anticancer investigation and molecular docking
Mrugesh Patel et al.
RSC ADVANCES (2021)
Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation
Mohamed Hagras et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)
Absorption, metabolism, excretion, and safety of [C-14]almonertinib in healthy Chinese subjects
Chen Zhou et al.
ANNALS OF TRANSLATIONAL MEDICINE (2021)
Anticancer, antimicrobial activities of quinoline based hydrazone analogues: Synthesis, characterization and molecular docking
Kanubhai D. Katariya et al.
BIOORGANIC CHEMISTRY (2020)
Investigations of antiproliferative and antioxidant activity of β-lactam morpholino-1,3,5-triazine hybrids
Somayeh Ranjbari et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Synthesis, biological evaluation and molecular modeling study of [1,2,4]-Triazolo[4,3-c]quinazolines: New class of EGFR-TK inhibitors
Wafaa A. Ewes et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Development of a Brigatinib degrader (SIAIS117) as a potential treatment for ALK positive cancer resistance
Ning Sun et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Selinexor for the treatment of multiple myeloma
Klaus Podar et al.
EXPERT OPINION ON PHARMACOTHERAPY (2020)
Synthesis and Transformation of 4-(1-Chloro-1-nitroethyl)-6,7-dimethoxy-2-methylquinazoline: Spectral Characterization and Anti-cancer Properties of some Novel Quinazoline Derivatives
Duong Quoc Hoan et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2020)
A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+
Amar Djemoui et al.
JOURNAL OF MOLECULAR STRUCTURE (2020)
Synthesis, structure-activity relationship and molecular docking studies of novel quinoline-chalcone hybrids as potential anticancer agents and tubulin inhibitors
Salimeh Mirzaei et al.
JOURNAL OF MOLECULAR STRUCTURE (2020)
New Isatin-Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity
Reem Al-Wabli et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2020)
FDA Approval Summary: Pembrolizumab plus Lenvatinib for Endometrial Carcinoma, a Collaborative International Review under Project Orbis
Shaily Arora et al.
CLINICAL CANCER RESEARCH (2020)
Synthesis and biological evaluation of novel pyrazoline derivatives containing indole skeleton as anti-cancer agents targeting topoisomerase II
Yali Song et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
The discovery and development of binimetinib for the treatment of melanoma
Brian Tran et al.
EXPERT OPINION ON DRUG DISCOVERY (2020)
Entrectinib for the treatment of metastatic NSCLC: safety and efficacy
Andrea Sartore-Bianchi et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2020)
Synthesis, anticancer evaluation and molecular docking studies of 2,5-bis(indolyl)-1,3,4-oxadiazoles, Nortopsentin analogues
Reddymasu Sreenivasulu et al.
JOURNAL OF MOLECULAR STRUCTURE (2020)
Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development
Brooke Benner et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2020)
Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation
Wagdy M. Eldehna et al.
MARINE DRUGS (2020)
Cytotoxicity, anticancer, and antioxidant properties of mono and bis-naphthalimido β-lactam conjugates
Nassim Borazjani et al.
MEDICINAL CHEMISTRY RESEARCH (2020)
Acalabrutinib and Its Therapeutic Potential in the Treatment of Chronic Lymphocytic Leukemia: A Short Review on Emerging Data
Krista Isaac et al.
CANCER MANAGEMENT AND RESEARCH (2020)
Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates
Lindsay Ferguson et al.
MOLECULES (2020)
Molecular Hybrids Integrated with Benzimidazole and Pyrazole Structural Motifs: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies
Ramar Sivaramakarthikeyan et al.
ACS OMEGA (2020)
The European Medicines Agency Review of Gilteritinib (Xospata) for the Treatment of Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia with anFLT3Mutation
Kyriaki Tzogani et al.
ONCOLOGIST (2020)
Synthesis, EGFR-TK inhibition and anticancer activity of new quinoxaline derivatives
Eman A. Ahmed et al.
SYNTHETIC COMMUNICATIONS (2020)
Prescribed drugs containing nitrogen heterocycles: an overview
Majid M. Heravi et al.
RSC ADVANCES (2020)
IMIDAZOLE AND CARBAZOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: MOLECULAR DOCKING STUDIES AND CYTOTOXIC ACTIVITY EVALUATION
Behbood Taheri et al.
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA (2020)
The role of fedratinib for the treatment of patients with primary or secondary myelofibrosis
Jeanne Palmer et al.
THERAPEUTIC ADVANCES IN HEMATOLOGY (2020)
Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors
Riham F. George et al.
BIOORGANIC CHEMISTRY (2019)
Design, synthesis, and apoptosis-promoting effect evaluation of novel pyrazole with benzo[d]thiazole derivatives containing aminoguanidine units
Da Chuan Liu et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)
Ionic liquids with methotrexate moieties as a potential anticancer prodrug: Synthesis, characterization and solubility evaluation
Rahman Md Moshikur et al.
JOURNAL OF MOLECULAR LIQUIDS (2019)
Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic Inducers
Aliya M. S. El Newahie et al.
MOLECULES (2019)
Design, Synthesis, and Evaluation of Some Novel Heterocycles Bearing Pyrazole Moiety as Potential Anticancer Agents
Nancy Abdelgawad et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2019)
Cytotoxic Effects of Newly Synthesized Heterocyclic Candidates Containing Nicotinonitrile and Pyrazole Moieties on Hepatocellular and Cervical Carcinomas
Amira A. El-Sayed et al.
MOLECULES (2019)
New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2
Rania Hamdy et al.
MOLECULES (2019)
Targeting hepatocellular carcinoma: Synthesis of new pyrazole-based derivatives, biological evaluation, DNA binding, and molecular modeling studies
Dina M. Omran et al.
BIOORGANIC CHEMISTRY (2019)
Synthesis and biological evaluation of purine-pyrazole hybrids incorporating thiazole, thiazolidinone or rhodanine moiety as 15-LOX inhibitors endowed with anticancer and antioxidant potential
Ola S. Afifi et al.
BIOORGANIC CHEMISTRY (2019)
Design, synthesis, biological evaluation and molecular modeling of new coumarin derivatives as potent anticancer agents
Eman A. Fayed et al.
MEDICINAL CHEMISTRY RESEARCH (2019)
Preparation of some novel imidazopyridine derivatives of indole as anticancer agents: one-pot multicomponent synthesis, biological evaluation and docking studies
Zohreh Bakherad et al.
RESEARCH ON CHEMICAL INTERMEDIATES (2019)
1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview
Khurshed Bozorov et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Synthesis, molecular modeling and biological evaluation of new pyrazolo [3, 4-b]pyridine analogs as potential antimicrobial, antiquorum-sensing and anticancer agents
N. S. El-Gohary et al.
BIOORGANIC CHEMISTRY (2019)
Synthesis and in vitro anticancer evaluation of some fused indazoles, quinazolines and quinolines as potential EGFR inhibitors
Esraa A. Abdelsalam et al.
BIOORGANIC CHEMISTRY (2019)
Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase
Yunhang Guo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Clinical evaluation of dacomitinib for the treatment of metastatic non-small cell lung cancer (NSCLC): current perspectives
Daniele Lavacchi et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2019)
Larotrectinib, a highly selective tropomyosin receptor kinase (TRK) inhibitor for the treatment of TRK fusion cancer
Noah Federman et al.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2019)
Fruquintinib: a novel antivascular endothelial growth factor receptor tyrosine kinase inhibitor for the treatment of metastatic colorectal cancer
Ying Zhang et al.
CANCER MANAGEMENT AND RESEARCH (2019)
Design, synthesis and in vitro evaluation of 6-amide-2-aryl benzoxazole/benzimidazole derivatives against tumor cells by inhibiting VEGFR-2 kinase
Xu Yuan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Irinotecan: 25 years of cancer treatment
Christian Bailly
PHARMACOLOGICAL RESEARCH (2019)
Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent
Zhangxu He et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
ChEMBL: towards direct deposition of bioassay data
David Mendez et al.
NUCLEIC ACIDS RESEARCH (2019)
Novel Biomedical Applications of Crosslinked Collagen
Lisha Gu et al.
TRENDS IN BIOTECHNOLOGY (2019)
Investigating the Anticancer Activity of lsatin/Dihydropyrazole Hybrids
Rita Meleddu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Duvelisib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Phosphoinositide 3-Kinases
Daniel A. Rodrigues et al.
PHARMACEUTICALS (2019)
Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors
Xiao-Yan Jin et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)
Novel indole derivatives as potential anticancer agents: Design, synthesis and biological screening
B. Prakash et al.
MEDICINAL CHEMISTRY RESEARCH (2018)
Curcumin inspired 2-chloro/phenoxy quinoline analogues: Synthesis and biological evaluation as potential anticancer agents
P. V. Sri Ramya et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
Identification of novel indole based heterocycles as selective estrogen receptor modulator
Ramit Singla et al.
BIOORGANIC CHEMISTRY (2018)
Design, synthesis and biological evaluation of novel 1,3,4-trisubstituted pyrazole derivatives as potential chemotherapeutic agents for hepatocellular carcinoma
Marwa F. Harras et al.
BIOORGANIC CHEMISTRY (2018)
US Food and Drug Administration Approval: Neratinib for the Extended Adjuvant Treatment of Early-Stage HER2-Positive Breast Cancer
Harpreet Singh et al.
CLINICAL CANCER RESEARCH (2018)
FDA Approval: Ribociclib for the Treatment of Postmenopausal Women with Hormone Receptor-Positive, HER2-Negative Advanced or Metastatic Breast Cancer
Anand Shah et al.
CLINICAL CANCER RESEARCH (2018)
Quinoxaline: An insight into the recent pharmacological advances
Sana Tariq et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Novel nicotinoyl pyrazoline derivates bearing N-methyl indole moiety as antitumor agents: Design, synthesis and evaluation
Kun Chen et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Quinazoline and quinazolinone as important medicinal scaffolds: a comparative patent review (2011-2016)
Abdul Hameed et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2018)
Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido[2,3-d]pyrimidine scaffold
Heba S. A. Elzahabi et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)
Design, Synthesis, and Evaluation of the Anticancer Properties of Novel Quinone Bearing Carbamyl beta-Lactam Hybrids
Nagaraju Payili et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2018)
Synthesis of some new Pyridine-based Heterocyclic Compounds with Anticipated Antitumor Activity
Sobhi M. Gomha et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2018)
Quinazolinone-Amino Acid Hybrids as Dual Inhibitors of EGFR Kinase and Tubulin Polymerization
Mohamed F. Zayed et al.
MOLECULES (2018)
Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation
Mohamed El-Naggar et al.
MOLECULES (2018)
FDA Approval Summary: Dabrafenib and Trametinib for the Treatment of Metastatic Non-Small Cell Lung Cancers Harboring BRAF V600E Mutations
Lauretta Odogwu et al.
ONCOLOGIST (2018)
Rational eco-compatible synthesis and biological screening of new highly functionalized pyrido[2,3-a]carbazole derivatives: A novel class of antioxidant and anticancer agents
Kripalaya Ratheesh Arya et al.
SYNTHETIC COMMUNICATIONS (2018)
Design and stereoselective synthesis of novel β-lactone and β-lactams as potent anticancer agents on breast cancer cells
Mahnoosh Rashidi et al.
TETRAHEDRON (2018)
Synthesis and Biological Screening of Pyrano[3,2-c]quinoline Analogues as Anti-inflammatory and Anticancer Agents
Kuldip D. Upadhyay et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2018)
Encorafenib and Binimetinib: First Global Approvals
Matt Shirley
DRUGS (2018)
Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development
Guoshuang Shen et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)
Design, Synthesis and SAR Study of Novel Spiro [Pyrimido[5,4-b]Quinoline-10,5-Pyrrolo[2,3-d]Pyrimidine] Derivatives as Promising Anticancer Agents
Asha V. Chate et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2018)
Studies on Synthesis of Novel Pyrido[2,3-d] pyrimidine Derivatives and Their Anticancer Activity
Veeraswamy Banda et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2018)
FDA Approval Summary: Midostaurin for the Treatment of Advanced Systemic Mastocytosis
Yvette L. Kasamon et al.
ONCOLOGIST (2018)
Design, synthesis and therapeutic potential of 3-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamide analogues
Sumit Tahlan et al.
CHEMISTRY CENTRAL JOURNAL (2018)
Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells
Wei Zhang et al.
FRONTIERS IN PHARMACOLOGY (2018)
Facile synthesis of indole heterocyclic compounds based micellar nano anti-cancer drugs
Imran Ali et al.
RSC ADVANCES (2018)
Acalabrutinib: First Global Approval
Anthony Markham et al.
DRUGS (2018)
Synthesis and Evaluation of Pyrido[2,3-d]pyrimidine and 1,8-Naphthyridine Derivatives as Potential Antitumor Agents
Mohamed S. Behalo et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2017)
Design, Synthesis, and Cytotoxicity Evaluation of 3-(5-(3-(aryl)-1-phenyl-1H-pyrazol-4-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)pyridine and 5-(3-(aryl)-1-phenyl-1H-pyrazol-4-yl)-3-(pyridin-3-yl)-4,5-dihydropyrazole-1-carbaldehyde Derivatives as Potential Anticancer Agents
Raquib Alam et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2017)
Biological Evaluation in Vitro and in Silico of Azetidin-2-one Derivatives as Potential Anticancer Agents
Fabian E. Olazaran et al.
ACS MEDICINAL CHEMISTRY LETTERS (2017)
Synthesis of hetero annulated isoxazolo-, pyrido- and pyrimido carbazoles: Screened for in vitro antitumor activity and structure activity relationships, a novel 2-amino-4-(3′-bromo-4′-methoxyphenyl)-8-chloro-11H-pyrimido[4,5-a]carbazole as an antitumor agent
Karunanidhi Murali et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities
Elizabeth Almeida Lafayette et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Development of a series of novel 4-anlinoquinazoline derivatives possessing quinazoline skeleton: Design, synthesis, EGFR kinase inhibitory efficacy, and evaluation of anticancer activities in vitro
Jin Chang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Design, synthesis and anticancer evaluation of novel pyrazole, pyrazolo[3,4-d]pyrimidine and their glycoside derivatives
Ibrahim F. Nassar et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2017)
Green synthetic approaches for biologically relevant organic compounds
Asha D. Jangale et al.
SYNTHETIC COMMUNICATIONS (2017)
The structure-guided discovery of osimertinib: the first US FDA approved mutant selective inhibitor of EGFR T790M
Sam Butterworth et al.
MEDCHEMCOMM (2017)
Synthesis and anticancer activity of new quinazoline derivatives
Hatem A. Abuelizz et al.
SAUDI PHARMACEUTICAL JOURNAL (2017)
Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib
Thomas Lee Collier et al.
NATURE COMMUNICATIONS (2017)
Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
Hatem A. Abdel-Aziz et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2017)
Structure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site
Dong-Jun Fu et al.
SCIENTIFIC REPORTS (2017)
FDA Approval Summary: Trabectedin for Unresectable or Metastatic Liposarcoma or Leiomyosarcoma Following an Anthracycline-Containing Regimen
Amy Barone et al.
CLINICAL CANCER RESEARCH (2017)
Phase II study of copanlisib, a PI3K inhibitor, in relapsed or refractory, indolent or aggressive lymphoma
M. Dreyling et al.
ANNALS OF ONCOLOGY (2017)
Benzimidazole Scaffold as Anticancer Agent: Synthetic Approaches and Structure-Activity Relationship
Neelima Shrivastava et al.
ARCHIV DER PHARMAZIE (2017)
Synthesis and biological evaluation of novel quinazoline-sulfonamides as anti-cancer agents
Suresh Poudapally et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Novel carbazole sulfonamide derivatives of antitumor agent: Synthesis, antiproliferative activity and aqueous solubility
Lianqi Sun et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Quinoxaline-Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity
Aliya M. S. El Newahie et al.
ARCHIV DER PHARMAZIE (2016)
Synthesis of novel triazole/isoxazole functionalized 7-(trifluoromethyl)pyrido[2,3-d]pyrimidine derivatives as promising anticancer and antibacterial agents
R. Naresh Kumar et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Synthesis of novel hydrazone and azole functionalized pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents
P. Nagender et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
FDA Approval: Alectinib for the Treatment of Metastatic, ALK-Positive Non-Small Cell Lung Cancer Following Crizotinib
Erin Larkins et al.
CLINICAL CANCER RESEARCH (2016)
Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines
Vanessa Desplat et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Design, synthesis and biological evaluation of novel benzimidazole-2-substituted phenyl or pyridine propyl ketene derivatives as antitumour agents
Lin-tao Wu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Novel triazole hybrids of myrrhanone C, a natural polypodane triterpene: Synthesis, cytotoxic activity and cell based studies
Madasu Chandrashekhar et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Synthesis and evaluation of in vitro antiproliferative activity of new ethyl 3-(arylethynyl)quinoxaline-2-carboxylate and pyrido[4,3-b] quinoxalin-1(2H)-one derivatives
Majdi Hajri et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Design, synthesis, anti-tumor activity, and molecular modeling of quinazoline and pyrido[2,3-d]pyrimidine derivatives targeting epidermal growth factor receptor
Ju Hou et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids
Mostafa M. Ghorab et al.
MOLECULES (2016)
Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs
Robert Roskoski
PHARMACOLOGICAL RESEARCH (2016)
β-Lactams and β-Lactamase Inhibitors: An Overview
Karen Bush et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
Synthesis of Some Polysubstituted Nicotinonitriles and Derived Pyrido[2,3-d]pyrimidines as In Vitro Cytotoxic and Antimicrobial Candidates
Hassan M. Faidallah et al.
JOURNAL OF CHEMISTRY (2016)
Current status of pyrazole and its biological activities
Mohd Javed Naim et al.
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2016)
Prostate-Specific Membrane Antigen Targeted Polymersomes for Delivering Mocetinostat and Docetaxel to Prostate Cancer Cell Spheroids
Fataneh Karandish et al.
ACS OMEGA (2016)
Idelalisib: A Novel PI3K Inhibitor for Chronic Lymphocytic Leukemia
Arpita Shah et al.
ANNALS OF PHARMACOTHERAPY (2015)
Molecular modeling studies and synthesis of novel quinoxaline derivatives with potential anticancer activity as inhibitors of c-Met kinase
Hebat-Allah S. Abbas et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells
Ravindra M. Kumbhare et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
FDA Approval Summary: Olaparib Monotherapy in Patients with Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer Treated with Three or More Lines of Chemotherapy
Geoffrey Kim et al.
CLINICAL CANCER RESEARCH (2015)
FDA Approval: Ibrutinib for Patients with Previously Treated Mantle Cell Lymphoma and Previously Treated Chronic Lymphocytic Leukemia
R. Angelo de Claro et al.
CLINICAL CANCER RESEARCH (2015)
Synthesis and biological evaluation of 2,4-diaminopyrimidines as selective Aurora A kinase inhibitors
Wen-Wen Qin et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents
Wagdy M. Eldehna et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Palbociclib: a first-in-class CDK4/CDK6 inhibitor for the treatment of hormone-receptor positive advanced breast cancer
Janice Lu
JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)
Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine's Tool Box
Pedro Martins et al.
MOLECULES (2015)
Synthesis and biological evaluation of novel pyrano[3,2-c]carbazole derivatives as anti-tumor agents inducing apoptosis via tubulin polymerization inhibition
Pannala Padmaja et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2015)
Synthesis and biological evaluation of new pyridines containing imidazole moiety as antimicrobial and anticancer agents
Ikhlass Abbas et al.
TURKISH JOURNAL OF CHEMISTRY (2015)
Copper-Catalyzed Domino Synthesis of Nitrogen Heterocycle-Fused Benzoimidazole and 1,2,4-Benzothiadiazine 1,1-Dioxide Derivatives
Daoshan Yang et al.
ACS COMBINATORIAL SCIENCE (2015)
Synthesis and In Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives
Zahra Najafi et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2015)
Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2
Lei Shi et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Synthesis and biological evaluation of novel pyrimidine-benzimidazol hybrids as potential anticancer agents
Kun-Peng Shao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Solvent-free synthesis of heteroannulated carbazoles: A novel class of anti-tumor agents
Leena Vairavelu et al.
BIOORGANIC CHEMISTRY (2014)
Design, synthesis and molecular modeling of pyrazole-quinoline-pyridine hybrids as a new class of antimicrobial and anticancer agents
Chetan B. Sangani et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
A simple approach to fused pyrido[ 2,3-d] pyrimidines incorporating khellinone and trimethoxyphenyl moieties as new scaffolds for antibacterial and antifungal agents
Khadiga M. Abu-Zied et al.
HETEROCYCLIC COMMUNICATIONS (2014)
Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogues of Combretastatin-A4 as Anticancer Agents
Shilong Zheng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
FDA Approval Summary: Crizotinib for the Treatment of Metastatic Non-Small Cell Lung Cancer With Anaplastic Lymphoma Kinase Rearrangements
Dickran Kazandjian et al.
ONCOLOGIST (2014)
Cytotoxicity of silver(I), gold(I) and gold(III) complexes of a pyridine wingtip substituted annelated N-heterocyclic carbene
Joydev Dinda et al.
RSC ADVANCES (2014)
Crizotinib: A New Treatment Option for ALK-Positive Non-Small Cell Lung Cancer
Cindy L. O'Bryant et al.
ANNALS OF PHARMACOTHERAPY (2013)
Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents
Qian-Ru Du et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Synthesis, DNA-binding abilities and anticancer activities of triazole-pyrrolo[2,1-c][1,4]benzodiazepines hybrid scaffolds
Chung-Yu Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Porfimer-sodium (Photofrin-II) in combination with ionizing radiation inhibits tumor-initiating cell proliferation and improves glioblastoma treatment efficacy
Liat Benayoun et al.
CANCER BIOLOGY & THERAPY (2013)
Trametinib: First Global Approval
Cameron J. M. Wright et al.
DRUGS (2013)
Dabrafenib: First Global Approval
Anita D. Ballantyne et al.
DRUGS (2013)
Afatinib: First Global Approval
Rosselle T. Dungo et al.
DRUGS (2013)
Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents
Xue-Quan Wang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: New anticancer agents
Asif Husain et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Design and stereoselective synthesis of novel isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents
Song-Lin Zhu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents
Ying-Chao Duan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Transient Exposure to Quizartinib Mediates Sustained Inhibition of FLT3 Signaling while Specifically Inducing Apoptosis in FLT3-Activated Leukemia Cells
Ruwanthi N. Gunawardane et al.
MOLECULAR CANCER THERAPEUTICS (2013)
TARGETED THERAPIES Afatinib-new therapy option for EGFR-mutant lung cancer
Helena A. Yu et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2013)
Synthesis of some new pyrimidine derivatives and evaluation of their anticancer and antibacterial activities
Omar A. Fathalla et al.
RESEARCH ON CHEMICAL INTERMEDIATES (2013)
Synthesis and anticancer activity of some fused pyrimidines and related heterocycles
S. A. Al-Issa
SAUDI PHARMACEUTICAL JOURNAL (2013)
Quinoline: A versatile heterocyclic
Akranth Marella et al.
SAUDI PHARMACEUTICAL JOURNAL (2013)
Design and synthesis of benzo[c,d]indolone-pyrrolobenzodiazepine conjugates as potential anticancer agents
Ahmed Kamal et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole
Xiao-Dong Yang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4] benzodiazepin-5-one, and diversity-oriented synthesis of benzothiazoles
D. Subhas Bose et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Synthesis of novel fused heterocycle-oxa-aza-phenanthrene and anthracene derivatives via sequential one-pot synthesis in aqueous micellar system
Madhulika Srivastava et al.
GREEN CHEMISTRY (2012)
Anticancer activities of genistein-topotecan combination in prostate cancer cells
Vanessa Hoermann et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2012)
Anticancer Drug Discovery from the Marine Environment
Candida Nastrucci et al.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2012)
Synthesis and cytotoxic activities of novel hybrid compounds of imidazole scaffold-based 2-substituted benzofurans
Wen-Jian Song et al.
RSC ADVANCES (2012)
Synthesis, characterization of some benzazoles bearing pyridine moiety: Search for novel anticancer agents
Heba S. A. Elzahabi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity
C. Kurumurthy et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Design, synthesis and biological evaluation of substituted 11H-benzo[a] carbazole-5-carboxamides as novel antitumor agents
Yu-Qin Wang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Mocetinostat (MGCD0103): a review of an isotype-specific histone deacetylase inhibitor
Yanis Boumber et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2011)
Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-N′-arylguanidines: Access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivatives
Julien Debray et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects
Miriam Carr et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Asymmetric synthesis of anticancer β-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate
Bimal K. Banik et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
New quinoxaline 1, 4-di-N-oxides: Anticancer and hypoxia-selective therapeutic agents
Magda M. F. Ismail et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl]acetamide derivatives and evaluation of their anticancer activity
Yusuf Ozkay et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Is there a role for mitomycin C in metastatic colorectal cancer?
Anastasios Dimou et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)
Discovery and development of the anticancer agent salinosporamide A (NPI-0052)
William Fenical et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Trabectedin: an anticancer drug from the sea
Kristen N. Ganjoo et al.
EXPERT OPINION ON PHARMACOTHERAPY (2009)
Review on supermolecules as chemical drugs
Zhou ChengHe et al.
SCIENCE IN CHINA SERIES B-CHEMISTRY (2009)
Nilotinib: A Second-Generation Tyrosine Kinase Inhibitor for the Treatment of Chronic Myelogenous Leukemia
David L. DeRemer et al.
CLINICAL THERAPEUTICS (2008)
FDA Drug Approval Summary: Lapatinib in Combination with Capecitabine for Previously Treated Metastatic Breast Cancer That Overexpresses HER-2
Qin Ryan et al.
ONCOLOGIST (2008)
Crystal-state studies on p-toluenesulfonates of N-oxyimides -: a possible structural basis of serine proteases inhibition
P Stefanowicz et al.
NEW JOURNAL OF CHEMISTRY (2006)
FDA drug approval summary:: Erlotinib (Tarceva®) tablets
MH Cohen et al.
ONCOLOGIST (2005)
Pyrimidine as constituent of natural biologically active compounds
IM Lagoja
CHEMISTRY & BIODIVERSITY (2005)
Reduction of drug toxicity using dendrimers based on melamine
Michael F. Neerman et al.
MOLECULAR PHARMACEUTICS (2004)
Stereoselective synthesis of β-lactams with polyaromatic imines:: Entry to new and novel anticancer agents
I Banik et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
FDA drug approval summary: Gefitinib (ZD1839) (Iressa (R)) tablets
MH Cohen et al.
ONCOLOGIST (2003)
Preclinical toxicity studies of kahalalide F, a new anticancer agent: single and multiple dosing regimens in the rat
AP Brown et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2002)
Synthesis of 2,3,5-substituted pyrrole derivatives
PMT Ferreira et al.
TETRAHEDRON LETTERS (2002)