4.7 Editorial Material

Special Issue Plastic and Reconstructive Surgery in Personalized Medicine

Related references

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Editorial Material Surgery

Paradoxical Perfusion Reaction of the contralateral Hand after Hand MRI

Dominik Promny et al.

HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE (2023)

Article Radiology, Nuclear Medicine & Medical Imaging

Clinical Application of Ultrahigh-Field-Strength Wrist MRI: A Multireader 3-T and 7-T Comparison Study

Rafael Heiss et al.

Summary: This study compared the subjective image quality of 3T and 7T ultrahigh-field-strength wrist MRI and found that 7T MRI had potential advantages in cartilage assessment, while 3T MRI was superior in evaluating the triangular fibrocartilage complex and wrist ligaments.

RADIOLOGY (2023)

Article Surgery

Complications and their management following axillary, inguinal and iliac lymph node dissection

Ingo Ludolph et al.

Summary: Lymphadenectomy is an essential part of surgical tumor therapy despite potential complications, and conservative or surgical treatments are available for secondary lymphedema.

CHIRURGIE (2023)

Article Health Care Sciences & Services

Intra- and Early Postoperative Evaluation of Malperfused Areas in an Irradiated Random Pattern Skin Flap Model Using Indocyanine Green Angiography and Near-Infrared Reflectance-Based Imaging and Infrared Thermography

Wibke Mueller-Seubert et al.

Summary: This study evaluated tissue perfusion after irradiation of random pattern flaps and found that indocyanine green angiography is more accurate in predicting necrotic areas. Preoperative fractional irradiation with a lower individual dose but a higher total dose has a more negative impact on flap perfusion.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Health Care Sciences & Services

Combined versus Single Perforator Propeller Flaps for Reconstruction of Large Soft Tissue Defects: A Retrospective Clinical Study

Amir K. Bigdeli et al.

Summary: This study aimed to investigate the application of combined perforator propeller flaps (PPFs) in the reconstruction of large soft tissue defects. The results showed that combined PPFs are a reliable technique for the reconstruction of large soft tissue defects in the trunk and proximal lower extremity.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Engineering, Biomedical

Microvascular development in the rat arteriovenous loop model in vivo-A step by step intravital microscopy analysis

Ravikumar Vaghela et al.

Summary: The AV loop model is a key technique in tissue engineering that addresses the problem of vascular support. This study used a novel intravital microscopy approach to observe the process of vascularization in hydrogels. GelMA proved to be a better matrix compared to fibrin in terms of microvessel formation and network maturation. This study provides a new tool for understanding important events in tissue regeneration.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2022)

Review Health Care Sciences & Services

Defect Coverage after Forequarter Amputation-A Systematic Review Assessing Different Surgical Approaches

Denis Ehrl et al.

Summary: This article systematically reviews reconstructive options after forequarter amputation (FQA), with emphasis on personalized surgical technique and outcome. The study found that osteomusculocutaneous fillet flaps are a safe and advantageous reconstruction option, and the use of targeted muscle reinnervation (TMR) can reduce phantom limb and neuroma pain.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Health Care Sciences & Services

Intraoperative Blood Flow Analysis of DIEP vs. ms-TRAM Flap Breast Reconstruction Combining Transit-Time Flowmetry and Microvascular Indocyanine Green Angiography

Alexander Geierlehner et al.

Summary: This study compared the blood flow characteristics of DIEP and ms-TRAM flaps for autologous breast reconstruction and found differences in blood flow volume, vascular resistance, and intrinsic transit time between the two flaps. These findings help improve the safety of the procedure by determining predictive values for vascular compromise.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Health Care Sciences & Services

Assessment of Mastectomy Skin Flaps for Immediate Reconstruction with Implants via Thermal Imaging-A Suitable, Personalized Approach?

Hanna Luze et al.

Summary: Preoperative screening and intraoperative thermal imaging assessment can reduce postoperative complications and improve patient outcomes.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Health Care Sciences & Services

The Free Myocutaneous Tensor Fasciae Latae Flap-A Workhorse Flap for Sternal Defect Reconstruction: A Single-Center Experience

Amir Khosrow Bigdeli et al.

Summary: This study investigated the clinical outcome of free myocutaneous tensor fasciae latae (TFL) flap reconstruction for sternal defects. It found that the procedure had few complications and resulted in satisfactory functional and aesthetic outcomes at the donor-site.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Health Care Sciences & Services

Microsurgical Transplantation of Pedicled Muscles in an Isolation Chamber-A Novel Approach to Engineering Muscle Constructs via Perfusion-Decellularization

Aijia Cai et al.

Summary: This study established a rat model of heterotopic microvascular muscle transplantation in an isolation chamber, which serves as a base for future studies on the transplantation of perfusion-decellularized muscle constructs.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Health Care Sciences & Services

Improving the Safety of DIEP Flap Transplantation: Detailed Perforator Anatomy Study Using Preoperative CTA

Katharina Frank et al.

Summary: This study compared the different aspects of perforator anatomy in autologous breast reconstruction, finding that the largest perforator often originates from the medial branch of the deep inferior epigastric artery and frequently has a direct connection to the superior/inferior epigastric vein, making medial row perforators the ideal choice for DIEP flap transplantation.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Health Care Sciences & Services

The Number of Surgical Interventions and Specialists Involved in the Management of Patients with Neurofibromatosis Type I: A 25-Year Analysis

Chih-Kai Hsu et al.

Summary: This study presents a 25-year experience of utilizing a comprehensive multidisciplinary team-based surgical approach for treating NF-1 patients at a single institution. The study highlights the potential benefits of such an approach in providing comprehensive individualized care, reducing the number of surgical interventions and involvement of specialists.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Cell Biology

Specific features of ex-obese patients significantly influence the functional cell properties of adipose-derived stromal cells

Deborah Schmitz et al.

Summary: This study analyzed the effects of specific factors of ex-obese patients on adipose-derived stromal cell (ADSC) functions and found that age, sex, and weight loss method have an impact on ADSC functionality, with higher activity observed in individuals who lose weight through increased exercise and dietary changes.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Article Health Care Sciences & Services

Is Instillational Topical Negative Pressure Wound Therapy in Peri-Prosthetic Infections of the Breast Effective? A Pilot Study

Jasmin S. Gruener et al.

Summary: In this retrospective cohort study, the effectiveness of negative pressure wound treatment with instillation and dwell time (NPWTi-d) on peri-prosthetic breast infections was investigated. The results showed that NPWTi-d decreased bacterial burden and contributed to the healing process. The study suggests that NPWTi-d may have a positive impact on secondary reimplantation of breast prostheses.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Health Care Sciences & Services

Individualized Wound Closure-Mechanical Properties of Suture Materials

Elias Polykandriotis et al.

Summary: This study reviewed the physical properties of different suturing materials under mechanical load and found that the linear tensile strength decreased significantly with the increase in crushing load cycles. Different materials also exhibited varying resistance to crush loading.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Health Care Sciences & Services

An In Vitro Approach for Investigating the Safety of Lipotransfer after Breast-Conserving Therapy

Theresa Promny et al.

Summary: This in vitro study aimed to investigate the effects of lipotransfer on irradiated remaining breast tissue. The study found that treatment with conditioned medium from adipose-derived stem cells (ADSC) promoted transmigration and invasion of mammary epithelial cells and caused changes in cellular functions. However, only an effect on irradiated fibroblasts was observed.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Medicine, General & Internal

Effects of Different Pressure Levels in Topical Negative Pressure Application-Analysis of Perfusion Parameters in a Clinical Skin Model Using Multimodal Imaging Techniques

Emine Ceylan Aslan-Horch et al.

Summary: This study investigated the effects of topical negative pressure therapy on healthy tissue and found that higher negative pressure levels resulted in higher oxygen saturation and tissue temperature. New imaging devices were used to detect clinical changes and differences in microcirculation.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Biotechnology & Applied Microbiology

An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research

Ran An et al.

Summary: Animal models are important tools for studying breast cancer. A new three-dimensional in vivo arteriovenous loop model of human breast cancer was developed in this study, which can recapitulate the in vivo situation and tumor-stromal interaction. Alginate-fibrin hybrid matrices were considered as a powerful material for breast tumor engineering.

BIOENGINEERING-BASEL (2022)

Article Health Care Sciences & Services

Posttraumatic Lymphedema after Open Fractures of the Lower Extremity-A Retrospective Cohort Analysis

Johannes Maximilian Wagner et al.

Summary: Secondary lymphedema is a common clinical issue characterized by pain, recurrent skin infections, and the need for decongestive therapy. A study on 94 patients with lower extremity fractures found that 55% showed symptoms of secondary lymphedema, with 14% experiencing severe lymphedema. Further research is needed to better understand and address posttraumatic secondary lymphedema.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Health Care Sciences & Services

Non-Invasive and Surgical Modalities for Scar Management: A Clinical Algorithm

Khaled Dastagir et al.

Summary: Scar treatment requires careful planning and individualized strategies, which can be facilitated by a conceptual algorithm to improve clinical work and patient safety. An algorithm for scar management was developed based on retrospective analysis of patient data, case descriptions, and literature searches. Treatment options include conservative therapy, minimally invasive techniques, and surgical procedures with different flaps, aiming to provide a safe and effective approach for scar management.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Health Care Sciences & Services

Thermal, Hyperspectral, and Laser Doppler Imaging: Non-Invasive Tools for Detection of The Deep Inferior Epigastric Artery Perforators-A Prospective Comparison Study

Sebastian P. Nischwitz et al.

Summary: This study evaluated different non-invasive imaging modalities as possible alternatives for perforator location detection and found that thermal imaging can provide valuable supporting data in individualized procedure planning. Future larger cohort studies are needed to better assess the full potential of modern handheld thermal imaging devices.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Health Care Sciences & Services

New Approach to the Old Challenge of Free Flap Monitoring-Hyperspectral Imaging Outperforms Clinical Assessment by Earlier Detection of Perfusion Failure

Daniel G. E. Thiem et al.

Summary: Hyperspectral imaging (HSI) was found to detect compromised perfusion in free flaps significantly earlier than clinical monitoring, providing clinicians with a tool to simplify postoperative flap monitoring.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Health Care Sciences & Services

Indocyanine Green for Leakage Control in Isolated Limb Perfusion

Isabel Zucal et al.

Summary: Sarcomas are characterized by high metastatic potential and aggressive growth, and chemotherapy plays an important role in their treatment. Studies have long been focused on finding the optimal anti-cancer therapy with maximized local efficacy and minimized systemic side effects. The study presented a novel strategy using indocyanine green to track tumor perfusion with high-dose cytostatic therapy, proving to be a safe and cost-efficient method for precise leakage control in isolated limb perfusion.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Review Health Care Sciences & Services

Beyond the Knife-Reviewing the Interplay of Psychosocial Factors and Peripheral Nerve Lesions

Johannes C. Heinzel et al.

Summary: Peripheral nerve injuries not only impact physical capabilities, but also have a significant effect on psychosocial aspects of life. Factors such as pain, depression, stress, employment status, and worker's compensation can be influenced by peripheral nerve lesions and serve as predictors of functional outcomes. Interdisciplinary, individualized treatment is necessary to identify patients at risk and provide emotional support during their adaptation to new life situations.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Health Care Sciences & Services

Personalized Reconstruction of Genital Defects in Complicated Wounds with Vertical Rectus Abdominis Myocutaneous Flaps including Urethral Neo-Orifice

Raymund E. Horch et al.

Summary: Non-healing extensive wounds in the perineal region can lead to severe complications, and the modified VRAM flap technique, including the urethral orifice, offers a novel option to avoid urinary diversion and maintain quality of life in patients.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Health Care Sciences & Services

Free Myocutaneous Flap Assessment in a Rat Model: Verification of a Wireless Bioelectrical Impedance Assessment (BIA) System for Vascular Compromise Following Microsurgery

Yao-Kuang Huang et al.

Summary: This study successfully monitored the bio-impedance changes in free flaps following vascular compromise in a rat model using a BIA system. The experimental group showed significantly higher bio-impedances compared to the control group, with an increasing trend over time, indicating the potential for using BIA to monitor vascular status of flaps.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Health Care Sciences & Services

Preliminary Results of the Capasquelet Technique for Managing Femoral Bone Defects-Combining a Masquelet Induced Membrane and Capanna Vascularized Fibula with an Allograft

Alexis Combal et al.

Summary: The Capasquelet surgery showed satisfactory bone consolidation and early weight-bearing, with the induced membrane potentially playing a role in osteoinduction of the graft. Further studies with larger cohorts and longer follow-up periods are needed to better assess the implications of this two-stage reconstruction technique.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Health Care Sciences & Services

Is Hyperspectral Imaging Suitable for Assessing Collateral Circulation Prior Radial Forearm Free Flap Harvesting? Comparison of Hyperspectral Imaging and Conventional Allen's Test

Diana Heimes et al.

Summary: This study found a strong correlation between HSI and MAT in assessing collateral perfusion, with HSI proving to reliably differentiate between perfusion and occlusion. The results suggest that HSI could be a useful tool for non-medical personnel and provide an objective and reproducible method for assessing collateral perfusion.

JOURNAL OF PERSONALIZED MEDICINE (2021)