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Archival Human Temporal Bone: Anatomical and Histopathological Studies of Cochlear Implantation

Journal

JOURNAL OF PERSONALIZED MEDICINE
Volume 13, Issue 2, Pages -

Publisher

MDPI
DOI: 10.3390/jpm13020352

Keywords

cochlear implant; archival human temporal bone; new tissue formation; osteoneogenesis; macrophage response; human cochlear anatomy

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Since its FDA approval in 1984, cochlear implantation has been successfully used for restoring hearing in individuals with severe to profound hearing loss. It has also been applied to cases of single-sided deafness, hybrid electroacoustic stimulation, and implantation at different ages. The design of cochlear implants has evolved to improve processing technology and reduce surgical trauma and foreign body reaction.
Since being FDA approved in 1984, cochlear implantation has been used successfully to restore hearing in those with severe to profound hearing loss with broader applications including single-sided deafness, the use of hybrid electroacoustic stimulation, and implantation at all extremes of age. Cochlear implants have undergone multiple changes in the design aimed at improving the processing technology, while simultaneously minimizing the surgical trauma and foreign body reaction. The following review examines the human temporal bone studies regarding the anatomy of the human cochlea and how the anatomy relates to cochlear implant design, the factors related to complications after implantation, and the predictors of new tissue formation and osteoneogenesis. Histopathological studies are reviewed which aim to understand the potential implications of the effects of new tissue formation and inflammation following implantation.

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